Nazia chaudhary | Drug Repurposing | Young Scientist Award

Nazia chaudhary | Drug Repurposing | Young Scientist Award

Dr Nazia chaudhary, ACTREC, TMC, India

Dr. Nazia Chaudhary is a distinguished cancer researcher 🧬 with a Ph.D. focused on pathways promoting tumorigenesis and therapy resistance upon Plakophilin 3 loss 🎗️. Her academic journey includes notable projects on protease-producing thermophiles 🌡️ and mitochondrial function ⚡. She co-holds patents on Lipocalin-2 antibodies 🧪 and has published extensively in high-impact journals 📚, including Redox Biology and FEBS Letters. A DST Inspire Faculty Fellow (2023) 🌟, she has received numerous awards, including the Vaishno Endowment Prize 🏆 and Mahindra Talent Scholarships 🎓. Dr. Chaudhary’s impactful work has been presented globally 🌍, including at Cold Spring Harbor Laboratory, New York.

Publication Profile

Orcid

Academic Project

Dr. Nazia Chaudhary is an accomplished researcher with a Ph.D. focused on the project “Characterization of pathways that promote tumorigenesis, radio, and chemo-resistance upon Plakophilin 3 loss.” 💡🧬 She worked on isolating and characterizing protease and antimicrobial-producing thermophiles from Ganeshpuri hot springs at St. Xavier’s College, Mumbai (Jan-Apr 2015). 🌋🔬 Additionally, she contributed to the external project “MKT1 Dependent Regulation of Mitochondrial Function” at Tata Institute of Fundamental Research (May-Aug 2014). 🧪⚙️ Her EXSP project involved isolating and screening thermophilic Actinomycetes for enzymes with industrial importance. 🔍🌡️ Dr. Chaudhary’s diverse research showcases her expertise in microbiology and biotechnology. 🌟

Conference Attended

Dr. Nazia Chaudhary has showcased her research on various esteemed platforms. She presented a poster titled “Screening of Thermophilic Actinomycetes Capable of Producing Enzymes of Industrial Importance” at the Shri Sajjan Gupta Memorial Trophy for Excellence in Biological Science, held on December 11, 2012, at G.N. Khalsa College. Another poster, “Increase in Lipocalin2 Expression Upon Plakophilin3 Loss Confers Chemo and Radioresistance to Tumor Cells,” was presented at the Environmental Mutagen Society of India (EMSI) conference in January 2018 at BARC, Mumbai, and at the prestigious Mechanisms & Models of Cancer meeting in August 2018 at Cold Spring Harbor Laboratory, New York. 🌟🔬📊

Awards and Honors

Dr. Nazia Chaudhary is a distinguished scholar with multiple accolades. She was awarded the prestigious DST Inspire Faculty Award in 2023 and recognized for her research on lipocalin 2 expression and chemo-radiotherapy resistance at the 14th Indo-Australian Biotechnology Conference. She served as a Board of Studies member for Sophia College’s Zoology Department (2018-2021). Throughout her academic journey, she earned various honors, including the Ramidevi Murlidhar Jalan Award 🏆, Saifee Education Aid Scholarship 🎓, and the Mahindra Search for Talent Scholarship 🌟. Her exceptional performance also earned her the Mrs. A. Varghese Prize 🥇 and several other prestigious scholarships and awards.

Patent

Dr. Nazia Chaudhary, along with Sorab N. Dalal, Manjula Das, Sujan K. Dhar, and Smitha P. K., contributed to the development of “Antibodies Against Lipocalin-2 and Use Thereof.” This groundbreaking research led to two key milestones. The first was the PCT application (PCT/IN2020/051068) with publication no. WO/2021/137254 on July 8, 2021. The second was the Indian patent (DBT Indian Patent no: 202021000274) granted on July 30, 2021, published in the Patent Office journal no. 31/2021. These innovations hold significant potential for medical advancements. 🧬💉🧪🔬

Research Focus

Dr. Nazia Chaudhary’s research focuses on the molecular mechanisms of cancer progression, therapy resistance, and invasion, particularly in triple-negative breast cancer (TNBC) and colorectal cancer. She investigates the role of Lipocalin 2 (LCN2) in regulating cellular processes like focal adhesion formation, actin glutathionylation, and ferroptosis inhibition, which are critical for tumor cell migration and resistance to treatment. Her work explores the interplay between signaling pathways, such as Src activation and glutathione metabolism, to uncover potential vulnerabilities in cancer cells. 🧬💥💉🧪🧫

Publication Top Notes

Ms. Faezeh Aghajannataj Ahangarkola|Drug Delivery Systems | Best Researcher Award

Ms. Faezeh Aghajannataj Ahangarkola |Drug Delivery Systems|Best Researcher Award|

Ms. Faezeh Aghajannataj Ahangarkola at Babol Noshirvani University of Technology,Iran

PROFILE  

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Early Academic Pursuits 🎓

Faezeh Aghajannataj began her academic journey with a strong foundation in pure chemistry, earning a Bachelor of Science degree from the University of Mazandaran (UMZ) in Babolsar, Iran, in September 2018. Her undergraduate studies focused on the synthesis of pharmaceutical heterocyclics, particularly through multi-component reactions. Under the guidance of Dr. Robabeh Baharfar, Faezeh’s final project received a stellar grade of 4.0/4.0, demonstrating her early aptitude for research and her keen interest in the intersection of chemistry and pharmaceuticals.

Building on her success at UMZ, Faezeh pursued a Master of Science degree in Biotechnology at the Babol Noshirvani University of Technology (BNUT), Babol, Iran. Her graduate research centered on the development of enteric hard capsules for targeting the small intestine, utilizing innovative materials like Pullulan and Eudragit L-100. This research culminated in a thesis titled “Enteric Hard Capsules for Targeting Small Intestine by Pullulan and Eudragit L-100: Processing, Characterization, and In-vitro Drug Release,” which was awarded a perfect grade of 4.0/4.0 (19/20), reflecting the high quality and significance of her work under the mentorship of Dr. Ghasem Najafpour.

Professional Endeavors 🏢

Faezeh’s professional career is marked by a strong focus on research and development in the pharmaceutical and biotechnology industries. During her time at Iran Gelatin Capsule in Tehran, she played a pivotal role as a member of the R&D team from February 2022 to May 2023. Her work primarily involved researching and formulating pullulan capsules at an industrial scale, a task that required both technical expertise and innovative thinking. Additionally, she contributed to the formulation and evaluation of controlled release systems designed to produce enteric-coated capsules without synthetic materials or external coatings, a project that aligns with the growing demand for more natural and sustainable pharmaceutical solutions.

Faezeh also gained significant experience as a teaching assistant during her academic career. She assisted in courses such as Organic Chemistry Laboratory and Physical Chemistry Laboratory at UMZ, and Advanced Engineering Mathematics at BNUT, showcasing her ability to convey complex scientific concepts to students. Her teaching roles not only enriched her understanding of the subjects but also allowed her to contribute to the academic growth of her peers.

Contributions and Research Focus 🔬

Faezeh’s research interests lie at the crossroads of biotechnology, pharmaceutical sciences, and chemistry. Her master’s thesis on enteric hard capsules represents a significant contribution to the field of drug delivery systems, particularly in the development of targeted delivery mechanisms for the small intestine. This work, which involved detailed processing, characterization, and in-vitro drug release studies, has the potential to impact the way oral medications are formulated and administered, particularly in terms of improving drug efficacy and patient outcomes.

Her research has been recognized through the publication of her work in reputable scientific journals. One notable publication is “Towards a Novel Pullulan and Pullulan-Enteric Hard Capsules: Study of Drug Release and Crucial Capsule Features,” co-authored with Dr. Gh. Najafpour and R. Ramezani. This paper, accessible , highlights the innovative approach Faezeh has taken in her research, contributing valuable knowledge to the field of drug delivery systems.

Accolades and Recognition 🏆

Throughout her academic and professional career, Faezeh has consistently achieved high marks and recognition for her work. Her thesis was awarded a perfect grade, reflecting the high esteem in which her research is held. Additionally, her academic achievements during her bachelor’s and master’s studies are underscored by her strong GPA, which stands at 3.6/4.0 (16.95/20) for her master’s degree, and her consistently high grades in her coursework.

Her work has also been recognized within the academic community through her roles as a teaching assistant, where she earned the trust of her professors to guide and mentor students in complex scientific subjects.

Impact and Influence 🌍

Faezeh’s research on drug delivery systems, particularly her focus on enteric capsules, has the potential to significantly impact the pharmaceutical industry. By developing more effective and targeted drug delivery mechanisms, her work could lead to improved patient outcomes, particularly for those with conditions that require precise delivery of medication to the small intestine.

Her influence extends beyond her research, as her roles as a teaching assistant and R&D member have allowed her to mentor and collaborate with others in the field, spreading her knowledge and fostering innovation in both academic and industrial settings.

Legacy and Future Contributions 🌟

Faezeh Aghajannataj is poised to make lasting contributions to the fields of biotechnology and pharmaceutical sciences. Her innovative approach to drug delivery systems and her commitment to research excellence set her apart as a leading figure in her field. As she continues her career, her work is likely to inspire future research and development in the industry, particularly in the creation of more sustainable and effective pharmaceutical solutions.

🎓Publication 

Ethanol fermentation in an immobilized cell reactor using Saccharomyces cerevisiae

  • Authors   :Ghasem Najafpour, Habibollah Younesi, Ku Syahidah Ku Ismail
  • Journal    :Bioresource technology
  • Year         :2024

Piperine—the bioactive compound of black pepper: from isolation to medicinal formulations

  • Authors   :Leila Gorgani, Maedeh Mohammadi, Ghasem D Najafpour, Maryam Nikzad
  • Journal    :Comprehensive reviews in food science and food safety
  • Year         :2017

High-rate anaerobic digestion of palm oil mill effluent in an upflow anaerobic sludge-fixed film bioreactor

  • Authors   :GD Najafpour, AAL Zinatizadeh, AR Mohamed, M Hasnain Isa, H Nasrollahzadeh
  • Journal    :Process Biochemistry
  • Year         :2006

Treatment of pulp and paper mill wastewater by polyacrylamide (PAM) in polymer induced flocculation

  • Authors   :SS Wong, TT Teng, AL Ahmad, A Zuhairi, G Najafpour
  • Journal    :Journal of hazardous materials
  • Year         :2006

Power generation from organic substrate in batch and continuous flow microbial fuel cell operations

  • Authors   :Mostafa Rahimnejad, Ali Asghar Ghoreyshi, Ghasem Najafpour, Tahereh Jafary
  • Journal    :Applied Energy
  • Year         :2011