Assist. Prof. Dr. Basharat Ali | Drug Discovery and Development | Editorial Board Member
University of Baltistan | Pakistan
Assist. Prof. Dr. Basharat Ali is a distinguished scholar in medicinal, organic, and polymer chemistry, recognized for his multifaceted expertise in drug discovery, heterocyclic synthesis, catalytic system development, and molecular probe design. His academic journey began with strong foundational training in chemistry, leading him to advanced graduate and doctoral studies at the HEJ Research Institute of Chemistry, University of Karachi, where he specialized in the synthesis and biological evaluation of thiosemicarbazides, triazole derivatives, and other bioactive heterocycles. Over the course of his academic advancement, he built deep competence in multicomponent reactions, synthetic methodologies, and the design of fused heterocyclic systems, including innovations in tetrazole-pyrimidine chemistry. Dr. Ali’s career includes significant international research experiences, including a postdoctoral position at Soochow University in China, where he worked extensively on chemiluminescent dioxetane probes, fluorescent diagnostic markers, and natural product–derived anthraquinone analogs targeting infectious diseases. He also contributed to polymer chemistry research at Zhejiang University, focusing on olefin polymerization mechanisms, catalyst behavior, and the influence of environmental and structural variables on polymer characteristics. His earlier scientific engagements at the ICCBS in Karachi further strengthened his foundation in organic synthesis and advanced laboratory techniques. Dr. Ali has developed strong expertise across a wide range of analytical and instrumental methods, including NMR spectroscopy, mass spectrometry, IR, UV-Vis, HPLC, GC, LC-MS, GC-MS/MS, chromatographic separations, and controlled-atmosphere synthetic operations. Known for mentoring a substantial number of graduate students, he has guided research in medicinal chemistry, metal ion detection, environmental toxin sensing, and catalytic reaction design. His publication record spans high-impact journals in medicinal, organic, and bioorganic chemistry, with contributions addressing anticancer carbothioamides, chalcone derivatives for metabolic disorders, anti-inflammatory and analgesic analogs, urease inhibitors, and computationally guided pharmacophore identification targeting viral proteins. Dr. Basharat Ali currently serves in a university faculty role, contributing to teaching, research leadership, editorial responsibilities, and interdisciplinary collaboration. His ongoing work continues to bridge synthetic chemistry with biomedical applications, demonstrating a strong commitment to innovation, scientific rigor, and societal impact in the chemical sciences.
Profile: Google Scholar
Featured Publications
Li, S., Zhan, L., Zhao, W., Zhang, S., Ali, B., Fu, Z., Lau, T. K., Lu, X., Shi, M., & Li, C. Z. (2018). Revealing the effects of molecular packing on the performances of polymer solar cells based on A–D–C–D–A type non‑fullerene acceptors. Journal of Materials Chemistry A, 6(25), 12132–12141.
Ali, F., Khan, K. M., Salar, U., Iqbal, S., Taha, M., Ismail, N. H., & Perveen, S. (2016). Dihydropyrimidones: as novel class of β‑glucuronidase inhibitors. Bioorganic & Medicinal Chemistry, 24(16), 3624–3635.
Abbas, A., Ali, B., Khan, K. M., Iqbal, J., Rahman, S. ur, Zaib, S., & Perveen, S. (2019). Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies. Bioorganic Chemistry, 82, 163–177.
Ali, B., Khan, K. M., Hussain, S., Hussain, S., Ashraf, M., Riaz, M., & Wadood, A. (2018). Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies. Bioorganic Chemistry, 79, 34–45.
Naz, F., Latif, M., Salar, U., Khan, K. M., Al‑Rashida, M., Ali, I., Ali, B., & Taha, M. (2020). 4‑Oxycoumarinyl linked acetohydrazide Schiff bases as potent urease inhibitors. Bioorganic Chemistry, 105, 104365.
Salar, U., Khan, K. M., Taha, M., Ismail, N. H., Ali, B., Perveen, S., & Ghufran, M. (2017). Biology‑oriented drug synthesis (BIODS): In vitro β‑glucuronidase inhibitory and in silico studies on 2‑(2‑methyl‑5‑nitro‑1H‑imidazol‑1‑yl) ethyl aryl carboxylate derivatives. European Journal of Medicinal Chemistry, 125, 1289–1299.