Khaydar Yunusov | Drug Discovery and Development | Best Researcher Award

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Khaydar Yunusov | Drug Discovery and Development | Best Researcher Award

Prof. Khaydar Yunusov at Institute of Polymer Chemistry and Physics Uzbekistan Academy of Sciences, Uzbekistan.

Prof. Khaydar Yunusov is a distinguished polymer chemist from Uzbekistan with extensive expertise in nanotechnology, cellulose chemistry, and biomaterials. Since 2007, he has held key research and leadership roles at the Institute of Polymer Chemistry and Physics, contributing significantly to polymer-based biomedical innovations. 💊 He holds a Doctor of Science and leads groundbreaking projects on nanostructured antibacterial films, antiviral eye medications, and burn treatments. 📘 With several patents, international collaborations 🌍, and editorial roles in leading journals, Prof. Yunusov is a pioneering force in sustainable polymer research and nanomedical applications.

Publication Profile 

Orcid

Education

Prof. Khaydar Yunusov began his academic journey at the Tashkent Chemical Technological Institute, earning a Bachelor’s degree in Chemistry (2006) and a Master’s in Cellulose, Paper Chemistry, and Technology (2008). 📘 Driven by scientific excellence, he pursued a Doctor of Science in Technical Sciences (2009–2016), focusing on advanced polymer research. Since 2018, he has served as a Senior Scientific Researcher in Nanochemistry, Nanophysics, and Nanotechnology. 🧪 His research delves into nanostructured bactericidal preparations based on cellulose and its derivatives, emphasizing synthesis, properties, and production technologies. 🧬 His academic background provides a solid foundation for pioneering innovations in polymer science.

Experience

Prof. Khaydar Yunusov has cultivated a rich professional career in polymer science, beginning in 2007 as a researcher at the Institute of Polymer Chemistry and Physics, Uzbek Academy of Sciences, Tashkent. 📍 Over the years, he advanced through roles including junior researcher, senior researcher, and project manager, earning his Doctor of Science along the way. 🔬 His expertise spans polymer and cellulose chemistry, nanotechnology, and biomaterials. From 2019 to 2023, he served as a lab and project manager, driving innovation in nanostructured materials. 💼 Prof. Yunusov’s professional path reflects unwavering dedication to scientific discovery and technological advancement.

Research Focus 

Prof. Khaydar Yunusov is a pioneering scientist whose research spans polymer chemistry, cellulose technology, and nanochemistry. His core focus lies in designing biocompatible nanomaterials 🧫 such as nanostructured drug delivery systems, microneedles, hydrogels, and functional films for medical applications 🎯. He actively explores biodegradable polymers, nanoparticle synthesis (silver, selenium, zinc oxide), and antimicrobial and anticancer therapies 💊. His work intersects biotechnology, materials science, and pharmaceutical engineering, advancing targeted treatments and regenerative medicine 🧠🦠. With numerous high-impact publications, Prof. Yunusov is shaping the future of smart biomaterials and sustainable polymeric solutions.

Publication Top Notes

  • A red cell membrane-camouflaged nanoreactor for enhanced starvation/chemodynamic/ion interference therapy for breast cancer
  • A three-dimensional printable conductive composite dressing for accelerating wound healing under electrical stimulation
  • Core-shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management ( vol 12, pg 1064, 2024)
  • Fabrication of hollow microneedles with double-layer shell structure for rapid and prolonged local anesthesia
  • Homemade isothermal amplification-initiated Cas14a assay for rapid quantitative detection of aquatic RNA virus gene with no PAM
  • Iontophoresis-driven transdermal drug delivery system based on porous microneedles for hyperuricemia treatment
  • Real-time microbial growth curve (RMGC) system: an improved microplate reader with a graphical interface for automatic and high-throughput monitoring of microbial growth curves
  • Two-directions mechanical strength and high-barrier mechanisms of cellulose nanocrystal- based hybrids reinforced packaging with nacre-mimetic structure
  • Physico-chemical characteristics of dialdehyde carboxymethylcellulose/sericin graft copolymer
  • Synthesis, Characterization, and Cytotoxic Activity of Stable Selenium Nanoparticles‐Incorporated Carboxymethylcellulose Solution
  • Impact of cellulose supramolecular structure on its carboxymethylation reaction activity
  • Advances in the formation and properties of nanofiber biomaterials from polyvinyl alcohol/carboxymethylcellulose/nanosilver systems for medical applications
  • Obtaining Dialdehyde Carboxymethylcellulose Through Microwave Treatment
  • Core-shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Sebastian Ludwig | Clinical Trials | Best Research Article Award

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Sebastian Ludwig | Clinical Trials | Best Research Article Award

Assist. Prof. Dr. Sebastian Ludwig, Universität zu Köln, Germany

Dr. Sebastian Ludwig (b. 1982, Leipzig) is a distinguished gynecologist and urogynecologist, currently serving as Senior Consultant and Head of the Continence and Pelvic Floor Center at the University of Cologne. He earned his medical degree from Ruhr-University Bochum (2009) and completed his habilitation in 2023, focusing on standardization in urogynecological surgery. Dr. Ludwig is a certified clinical trial leader and expert in minimally invasive surgery. Passionate about women’s health, he plays a vital role in medical education. Married with one child, he resides in Cologne.

Publication Profile

Scopus

Education

Assist. Prof. Dr. Sebastian Ludwig 🎓 holds a Doctor of Medicine degree (magna cum laude) and has further distinguished himself by completing his habilitation, earning the venia legendi in Gynecology and Obstetrics. 🏥 His academic journey reflects a deep commitment to medical education, clinical research, and advancing women’s healthcare. With a passion for innovation and evidence-based practice, Dr. Ludwig continues to contribute significantly to his field, shaping the future of gynecological and obstetric medicine. His dedication to both patient care and academic excellence makes him a respected figure in medical education and research. 🔬📚

Experience

Assist. Prof. Dr. Sebastian Ludwig 🏥 has advanced through the medical ranks, starting as an assistant physician and progressing to Oberarzt (senior physician) at the University of Cologne’s Women’s Clinic. His expertise and leadership extend further as the Head of the Continence and Pelvic Floor Center, where he plays a pivotal role in specialized patient care and groundbreaking research. 🔬 His dedication to women’s health, particularly in urogynecology, underscores his commitment to improving treatment outcomes and advancing medical knowledge. Through his clinical and academic contributions, Dr. Ludwig continues to shape the future of gynecological care. 👨‍⚕️📚

Awards

Assist. Prof. Dr. Sebastian Ludwig 🎓 holds multiple prestigious certifications in clinical trials, urogynaecology, gynecological endoscopy, and medical research methodologies. 🏥🔬 These qualifications reflect his dedication to continuous professional development and adherence to the highest standards of research ethics. His expertise in cutting-edge medical techniques ensures optimal patient care and contributes to the advancement of gynecological science. 📚 His commitment to lifelong learning and innovation strengthens his role as a leading specialist in women’s health, making significant contributions to both clinical practice and academic research. 👨‍⚕️💡

Research Focus

Assist. Prof. Dr. Sebastian Ludwig is a dedicated researcher in minimally invasive gynecologic surgery 🏥🔬, with a primary focus on laparoscopic and open abdominal procedures for treating pelvic organ prolapse and related conditions. His work integrates advanced surgical techniques 🏗️, interdisciplinary approaches, and long-term patient outcomes 📊. His studies on uterine ligament replacement and colorectal-gynecological procedures contribute to improving women’s healthcare 👩‍⚕️💙. His research also explores trends in obstetrics 🤰📉, offering insights into evolving birth practices. With publications in top medical journals 📖🏆, Dr. Ludwig plays a crucial role in advancing female pelvic reconstructive surgery 🩺✨.

Publication Top Notes

Comparison of Open Abdominal and Laparoscopic Bilateral Uterosacral Ligament Replacement: A One-Year Follow-Up Study

Early safety and efficiency outcomes of a novel interdisciplinary laparoscopic resection rectopexy combined with sacrocolpopexy for women with obstructive defecation syndrome and pelvic organ prolapse: a single center study

Shifting Trends in Obstetrics: An 18-year Analysis of Low-risk Births at a German University Hospital

Georgina Pamela Coló | Gene Therapy | Best Researcher Award

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Georgina Pamela Coló | Gene Therapy | Best Researcher Award

Dr. Georgina Pamela Coló, INIBIBB-CONICET, Argentina

Dr. Georgina Pamela Coló is a distinguished molecular biologist specializing in cancer research. She earned her Ph.D. in Molecular Biology from the University of Buenos Aires (2007, Summa Cum Laude) and holds an MS in Biotechnology from Quilmes National University. Currently a Scientific Researcher at CONICET’s Instituto de Investigaciones Bioquímicas (INIBIBB) in Argentina, she also leads a Max Planck Institute partner group. Her research focuses on cancer progression and therapeutic innovations. With extensive international experience in Germany, Spain, and the U.S., Dr. Coló has authored impactful publications in top-tier journals.

Publication Profile

Scopus

Education

Dr. Georgina Pamela Coló 🎓 is a distinguished molecular biologist with a Ph.D. from the University of Buenos Aires, School of Sciences (2003-2007), where she graduated summa cum laude (10/10) under the mentorship of Dr. M.A. Costas. Prior to her doctorate, she earned an M.S. in Biotechnology (8.74/10) from Quilmes National University (1998-2002). Her academic journey began with a B.Sc. in Science and Technology (1998-2000) and training as a Laboratory Technician 🔬. With a strong foundation in biotechnology and molecular biology, Dr. Coló has made significant contributions to scientific research and innovation. 🧬✨

Experience

Dr. Georgina Pamela Coló 🧬 is a dedicated cancer researcher currently serving as a Scientific Researcher at CONICET (2024-present) at the Instituto de Investigaciones Bioquímicas (INIBIBB), Argentina. She previously worked as an Assistant Researcher (2019-2024) under Dr. Curino. Since 2018, she has led a Max-Planck-Institute partner group 🇩🇪 with Dr. Prof. Reinhard Fässler. Her career includes research fellowships in Spain 🇪🇸 and Germany, as well as postdoctoral studies at INIBIBB, Max-Planck-Institute, and CIB-CSIC. With extensive experience in molecular medicine and cancer biology 🔬, Dr. Coló continues to make groundbreaking contributions to biomedical research. ✨

Awards

Dr. Georgina Pamela Coló 🏆 has received numerous prestigious awards for her outstanding contributions to biomedical research. In 2021, she won the Best Poster Award 🖼️ at the Reunión de Sociedades de Biociencias in Argentina. She was honored with the JCI TOYP Award (2020) for scientific and technological development. In 2019, she received the Lucio Cherny Award for interdisciplinary research 🧬. Her accolades include the Best Poster Award (2018), multiple CONICET fellowships 🎓, and the Max Planck postdoctoral fellowship (2013-2016). Dr. Coló’s impactful research continues to be recognized on both national and international levels.

Research Focus

Dr. Georgina Pamela Coló is a researcher specializing in nanomedicine 🧪, oncology 🎗️, and proteomics 🧬. Her work focuses on amorphous silica nanoparticles and their antitumor activity in triple-negative breast cancer cells 🏥. She also investigates the proteomic effects of hemin in breast cancer, exploring molecular pathways and therapeutic targets. Her research integrates nanotechnology 🏗️ and biochemistry to develop innovative cancer treatments. Through cutting-edge proteomic analysis, she contributes to personalized medicine and targeted drug delivery 🎯. Her studies are highly relevant to pharmaceutical sciences 💊 and biomedical research 🔬, advancing potential cancer therapies.

Publication Top Notes

Amorphous silica nanoparticles exhibit antitumor activity in triple-negative breast cancer cells

Proteomic analysis of the effect of hemin in breast cancer

KYU SHIK MUN | Personalized Medicine | Best Researcher Award

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KYU SHIK MUN | Personalized Medicine | Best Researcher Award

Assist. Prof. Dr. KYU SHIK MUN, Cedars-Sinai Medical Center, United States

Assist. Prof. Dr. Kyu Shik Mun is a distinguished researcher in cystic fibrosis (CF) and biomedical engineering 🧬. As a Principal Investigator and Co-Director, he has led groundbreaking projects on CF-related diabetes, organ-on-a-chip models, and personalized CF therapy 🏥. His work, funded by organizations like the Cystic Fibrosis Foundation and Vertex Pharmaceuticals, has yielded significant patents and high-impact publications 📑. With 733 citations, an h-index of 10, and an i10-index of 10, Dr. Mun continues to drive innovations in CF research, bridging biomedical science and translational medicine 🔬.

Publication Profile

Google Scholar

Professional Background

Assist. Prof. Dr. Kyu Shik Mun earned his Ph.D. in the Materials Science and Engineering Program at the University of Cincinnati 🎓. In 2016, he joined the Cystic Fibrosis Research Center at Cincinnati Children’s Hospital, where he pioneered a microfluidic-based organ-on-chip program from scratch 🏥🧬. His groundbreaking research focused on studying cystic fibrosis and related disorders. In 2021, he was promoted to Assistant Professor at Cedars-Sinai 🏆, where he continues to advance in vitro cell culture models using organ-on-chip technology and 3D bioprinting 🖨️🔬, contributing to innovative solutions in biomedical research and personalized medicine.

Awards

Assist. Prof. Dr. Kyu Shik Mun has received numerous prestigious honors and awards throughout his academic and professional journey 🎖️. He was awarded multiple Outstanding Grade Scholarships at Gangneung National University 🏅 (2000–2009) and recognized for excellence with department and presidential awards 🏆. His achievements include a scholarship from the Korean Broadcasting System 📺 and the Korea Research Foundation 🌏. During his Ph.D. at the University of Cincinnati, he earned a University Graduate Scholarship 🎓 (2010–2014). His research has been recognized by the American Gastroenterological Association and the Cystic Fibrosis Foundation 🧬, receiving multiple Best Abstract and Early Career Investigator awards (2017–2024) 🥇.

Experience 

Assist. Prof. Dr. Kyu Shik Mun has been actively involved in non-clinical teaching, contributing to journal clubs and lab mentoring 📚🎤. He has delivered key presentations on organ-on-a-chip technology 🧬, including talks at Cincinnati Children’s Hospital (2020) and Cedars-Sinai (2021) 🏥. His mentorship spans postdoctoral fellows, research associates, and Ph.D. students, guiding projects in 3D bioprinting 🖨️ and patient-derived lung-on-a-chip models 🌬️. Since 2016, he has mentored 15 summer and rotation students—including high school, college, Ph.D., and MD candidates—on fabricating organ-on-a-chips and culturing cells, fostering the next generation of biomedical researchers 🔬.

Research Focus

Assist. Prof. Dr. Kyu Shik Mun’s research primarily focuses on nanotechnology 🧪, biosensors 🧫, and biomedical engineering 🏥. His work spans optical interferometric biosensors for label-free detection, organ-on-a-chip models for diseases like cystic fibrosis 🫁, and TiO₂ nanotube arrays for applications in solar cells ☀️ and photocatalysis. He also explores drug discovery 💊 by targeting molecular pathways in cystic fibrosis and related disorders. His interdisciplinary research integrates materials science 🏗️, biophysics ⚛️, and microfluidics 🔬 to develop innovative medical technologies, aiming to advance precision medicine 🎯 and renewable energy solutions 🌱.

Publication Top Notes

A Stable, Label-free Optical Interferometric Biosensor Based on TiO2 Nanotube Arrays

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Guided construction of single cell reference for human and mouse lung

Targeting the pregnane X receptor using microbial metabolite mimicry

Personalized medicine in CF: from modulator development to therapy for cystic fibrosis patients with rare CFTR mutations

Surface passivation of highly ordered TiO2 nanotube arrays and application to dye-sensitized solar cells using the concept of isoelectric point

Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

Guanylate cyclase 2C agonism corrects CFTR mutants

Cystic Fibrosis Human Organs-on-a-Chip

SON DINH PHONG | Gene Therapy | Best Researcher Award

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SON DINH PHONG | Gene Therapy | Best Researcher Award

Dr SON DINH PHONG, DUYTAN UNIVERSITY, Vietnam

Dr. Dinh Phong Son is a dedicated researcher in molecular medicine at Duy Tan University, Vietnam. With a Ph.D. from Guangxi Medical University, China, and a background in laboratory medicine from Hue University of Medicine and Pharmacy, his research focuses on molecular biomarkers for early disease detection 🧪🔬. He explores the LncRNA/CircRNA/miRNA/gene/protein-drug interaction network and gene-editing techniques like CRISPR/Cas9 for targeted therapy. His work on cardiovascular disease and cancer diagnostics has been published in prestigious journals 📚🧑‍🔬. Passionate about advancing molecular biology, he aspires to contribute to innovative breakthroughs in disease research.

Publication Profile

orcid

Education

Dr. Dinh Phong Son 🎓 holds a degree in Laboratory Medicine Technique from Hue University of Medicine and Pharmacy, Vietnam, and a Ph.D. in Molecular Medicine from Guangxi Medical University, China. 🧬 His expertise lies in molecular biology, with a strong focus on disease biomarkers and gene-targeted therapies. 🏥🔬 With a solid academic foundation, he has contributed significantly to scientific advancements, particularly in precision medicine and diagnostics. His research aims to enhance medical treatments by identifying key genetic markers, paving the way for innovative therapeutic approaches. 🌍✨ Dr. Son’s dedication to science continues to drive breakthroughs in healthcare. 💡👨‍⚕️

Research and Innovations

Dr. Son Dinh Phong 🔬 is deeply engaged in advancing molecular biology through next-generation sequencing and online medical databases. His primary focus is identifying potential biomarkers for early disease detection, including diabetes, cardiovascular diseases, stroke, and cancer. 🧬🩺 His research also explores gene-targeted therapies, utilizing CRISPR/Cas9 for gene editing, overexpression, and silencing. 🏥 His studies on LncRNA/CircRNA/miRNA/gene/protein-drug interaction networks provide a foundation for future medical breakthroughs. 📊✨ Committed to innovation, Dr. Son’s ongoing work (2023-2025) aims to drive scientific progress, hoping for greater support to expand molecular biology research worldwide. 🌍💡

Research Contributions

Dr. Son Dinh Phong 🔬 is highly proficient in advanced molecular biology techniques, including PCR, qPCR, and sequencing analysis 🧪🧬. He specializes in CRISPR/Cas9 genome editing, RNA silencing, and overexpression assays, contributing to groundbreaking gene therapy research. 🏥 His expertise also includes cell culture, western blotting, and fluorescence in situ hybridization, essential for studying gene expression and protein interactions. 🔍🧫 Additionally, he excels in bioinformatics and molecular docking simulations, enabling in-depth analysis of gene interactions and drug responses. 💻💊 With a strong foundation in computational biology, Dr. Son continues to drive innovation in precision medicine and molecular diagnostics. 🚀✨

Editorial Appointments

Dr. Son Dinh Phong 🌍🔬 actively contributes to the global scientific community through his extensive research and publications. While specific editorial roles, consultancy projects, or industry collaborations may not be listed, his scholarly work reflects deep engagement in molecular biology and precision medicine. 🧬📖 His ORCID profile further validates his impactful contributions, showcasing his dedication to advancing medical research. 🏥✨ Through collaborations and scientific discourse, Dr. Son continues to push the boundaries of innovation, striving to enhance disease diagnostics and therapeutic strategies. His commitment to research ensures lasting contributions to the ever-evolving field of molecular medicine. 💡🚀

Research Focus

Dr. Son Dinh Phong’s research primarily focuses on cardiovascular diseases 🫀, non-coding RNAs 🧬, and bioinformatics-driven biomarker discovery 🖥️. His work explores circular RNAs (circRNAs) and microRNAs (miRNAs) in coronary heart disease (CHD) 🏥, revealing their role as competing endogenous RNAs (ceRNAs) in gene regulation. Additionally, he investigates serum miRNAs as potential diagnostic biomarkers for various cancers 🎗️ and employs computational approaches 🔬 to identify key regulatory networks in diseases like latent tuberculosis 🦠. His studies integrate molecular biology, genomics, and systems biology to advance precision medicine 🎯 and therapeutic innovations 💊 for complex diseases.

Publication Top Notes

Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation

Hsa_circRNA_0000284 acts as a ceRNA to participate in coronary heart disease progression by sponging miRNA-338-3p via regulating the expression of ETS1

Potential diagnostic value of serum microRNAs for 19 cancer types: a meta-analysis of bioinformatics data

Identification of hsa_circ_0001445 of a novel circRNA-miRNA-mRNA regulatory network as potential biomarker for coronary heart disease

Construction of miRNAs and gene expression profiles associated with ischemic cardiomyopathy: Bioinformatics analysis

Chuan Fan | Nanomedicine | Best Researcher Award

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Chuan Fan | Nanomedicine | Best Researcher Award

Dr Chuan Fan,Linyi University,China

Dr. Chuan Fan 🎓🔬 is a lecturer at Linyi University’s School of Chemistry and Chemical Engineering, specializing in multifunctional hydrogel dressing systems and acoustic-driven biomarker analysis. He earned his degree from the University of Science and Technology Beijing under Prof. Xueji Zhang. With 30+ SCI- and Scopus-indexed publications and a ResearchGate citation index of 984, his research contributes to pharmacology and drug delivery. However, he is in the early stages of securing patents, grants, and industry collaborations. His work holds promise for advanced therapeutic applications, making him a strong contender for early-career research awards. 🏆📚

Publication Profile

Scopus

Academic and Professional Background

Dr. Chuan Fan 🎓 pursued his studies at the University of Science and Technology Beijing under the esteemed mentorship of Professor Xueji Zhang. Since August 2023, he has been serving as a lecturer at Linyi University’s School of Chemistry and Chemical Engineering 🏫. His research primarily focuses on multifunctional hydrogel dressing systems and acoustic-driven enrichment analysis of trace biomarkers 🧪. Through his dedication and innovation, Dr. Fan has made significant progress in his field, contributing to multiple high-quality publications in indexed journals 📚. His work continues to advance scientific knowledge and practical applications in chemical and biomedical research. 🚀

Research and Innovations

Dr. Chuan Fan has made notable contributions to his field, authoring over 30 SCI- and Scopus-indexed articles 📄, reflecting his dedication to research. His citation index on ResearchGate stands at 984 🔍, indicating a moderate academic impact. However, his research engagement appears to be in its early stages, with no completed projects and only two ongoing ones 🧪. Despite his publication record, he has yet to secure patents, editorial appointments, industry collaborations, consultancy projects, or book publications 📚. While his work is promising, further achievements in these areas could enhance his influence in the scientific community. 🌟

Contributions and Impact

Dr. Chuan Fan is dedicated to advancing pharmacology and drug delivery systems, with a focus on enhancing targeted therapies and improving patient outcomes 💊🔬. His research explores innovative methods to optimize drug efficacy and minimize side effects, contributing to the evolving landscape of precision medicine. While he asserts that his work has gained significant recognition, concrete evidence such as prestigious awards, keynote invitations, or high-impact citations remains unspecified 🏆📖. Despite this, his contributions reflect a commitment to revolutionizing drug delivery, potentially shaping future advancements in personalized treatment strategies for various medical conditions 🚀🧬.

Professional Engagements

Dr. Chuan Fan currently does not hold any professional memberships, editorial roles, or collaborative positions, which are key indicators of a researcher’s influence in the academic community 📚. Actively participating in international conferences 🌍, joining professional societies 🏛️, and engaging in research networks 🔬 would significantly enhance his professional standing. Such involvement fosters knowledge exchange, strengthens collaborations, and increases visibility within the scientific community. By contributing to peer-reviewed journals ✍️, networking with experts 🤝, and taking on leadership roles, Dr. Fan can expand his impact and establish himself as a recognized authority in his field of expertise.

Research Focus

Dr. Chuan Fan’s research focuses on biomedical materials 🧪, nanotechnology 🧫, and wound healing 🩹, particularly in developing visible light-activated Ti-MOF (titanium-metal-organic frameworks) hydrogel composites for chronic diabetic wound healing 🦶. His work integrates photocatalysis 🌞, drug delivery 💊, and biocompatible hydrogels to enhance tissue regeneration and antimicrobial effects. By loading metformin into these advanced biomaterials, Dr. Fan aims to promote faster and more effective healing of diabetic wounds, addressing a critical medical challenge. His research sits at the intersection of materials science 🏗️, biomedical engineering ⚙️, and regenerative medicine 🧬.

Publication Top Notes

Visible light-activated Ti-MOF loaded metformin-hydrogel composite dressing for accelerated chronic diabetic wound healing