Prof Dr. Ronit Sverdlov|Pharmacology|Best Researcher Award

Prof Dr. Ronit Sverdlov|Pharmacology|Best Researcher Award

Prof Dr. Ronit Sverdlov at Maastricht University,Netherlands

PROFILE  

ORCID

Scopus

 

Early Academic Pursuits 🎓

Dr. Ronit Shiri-Sverdlov’s academic journey began with a Master’s degree in Biochemistry and Cellular Biology from Tel-Aviv University in Israel, where she graduated magna cum laude. This period was instrumental in shaping her deep interest in cellular and molecular mechanisms, a theme that would remain central to her later work. Building on her foundational knowledge, she pursued a Ph.D. in Molecular Genetics at Tel-Aviv University’s Sheba Medical Center, under the supervision of Prof. E. Friedman. Her doctoral research, focused on identifying germline mutations in the BRCA1 and BRCA2 genes among high-risk Jewish and Arab populations, underscored her commitment to precision genetics and earned her a magna cum laude distinction upon graduation in 2002.

Professional Endeavors 💼

Dr. Shiri-Sverdlov joined Maastricht University’s Department of Molecular Genetics in 2001 as a postdoctoral researcher, working with Prof. M.H. Hofker. Her early postdoctoral work provided the groundwork for her lifelong focus on metabolic health, hepatic inflammation, and cholesterol metabolism. In 2004, she transitioned into a faculty position, first as an Assistant Professor and later, an Associate Professor by 2012. In 2016, she was appointed a Full Professor of Hepatic Inflammation and Metabolic Health, reflecting her leadership and expertise in the field. Dr. Shiri-Sverdlov currently leads a vibrant research team within the Faculty of Health, Medicine, and Life Sciences at Maastricht University, where she oversees projects focusing on liver disease, metabolic health, and inflammation under the NUTRIM School of Nutrition and Translational Research in Metabolism.

Contributions and Research Focus 🔬

Dr. Shiri-Sverdlov’s research centers on understanding and combating liver-related diseases, particularly non-alcoholic steatohepatitis (NASH), through molecular insights into cholesterol trafficking and hepatic inflammation. Her investigations have brought critical attention to lysosomal dysfunction as a biomarker for early NASH detection. This research has garnered substantial support, including a €1 million TKI grant in 2017 and several large fellowships from the Dutch Digestive Foundation and NWO ZonMw. Her work emphasizes the role of cholesterol metabolism in Kupffer cells (liver macrophages) and its impact on inflammatory pathways—a field where her studies continue to yield promising therapeutic insights.

Accolades and Recognition 🏆

Over the years, Dr. Shiri-Sverdlov has earned numerous prestigious awards. Her early career was marked by the VENI, VIDI, and ASPASIA fellowships from NWO ZonMw, which collectively supported her pioneering work in cholesterol metabolism and liver inflammation. She received the Marie Sklodowska-Curie Seal of Excellence in 2018, reflecting her proposal’s high evaluation score. She was also awarded the Education Prize by Maastricht University in 2018 for her leadership in developing the Biomedical Sciences curriculum. Additionally, she has been nominated for multiple awards, reflecting her influence in both research and teaching.

Impact and Influence 🌐

Dr. Shiri-Sverdlov has made a significant impact in the field of hepatic health through her research and mentorship. Her work on hepatic lysosomal biomarkers has been pivotal in early disease detection for NASH, with implications for both clinical practice and drug development. As a member of key grant committees, including the Netherlands Organization for Scientific Research (NWO) and the Novo Nordisk Foundation, she actively shapes the research landscape. Her collaboration with researchers across Europe, including those at the University of Reading and Strasbourg University, has contributed to a robust network of shared knowledge and advances in metabolic health.

Legacy and Future Contributions 🌱

Looking to the future, Dr. Shiri-Sverdlov is committed to advancing the understanding of liver diseases through cutting-edge research. Her work not only contributes to therapeutic advancements in NASH and hepatic inflammation but also inspires the next generation of scientists. Through her teaching roles, she continues to influence and guide students in Biomedical Sciences and Nutrition, instilling in them a commitment to rigorous research. Her legacy is further enriched by her leadership in scientific societies, where she champions innovative approaches to metabolic and hepatic health research.

🎓Publication 

Plasma cathepsin D as an early indicator of alcohol-related liver disease

  • Authors   :Li, M., Houben, T., Bitorina, A.V., Thiele, M., Shiri-Sverdlov, R.
    JHEP Reports,
  • Year         :2024

The Modulatory Effects of Fatty Acids on Cancer Progression

  • Authors   :Westheim, A.J.F., Stoffels, L.M., Dubois, L.J., Shiri-Sverdlov, R., Theys, J.
  • Journal    : Biomedicines
  • Year         :2023

All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma

  • Authors   :van Mourik, H., Li, M., Baumgartner, S., Theys, J., Shiri-Sverdlov, R.
  • Journal    :Biomedicines
  • Year         :2022

Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy

  • Authors   : Westheim, A.J.F., Stoffels, L.M., Dubois, L.J., Shiri-Sverdlov, R., Theys, J.
  • Journal    : Frontiers in Nutrition
  • Year         :2022

Serum CathepsinD in pregnancy: Relation with metabolic and inflammatory markers and effects of fish oils and probiotics

  • Authors   : Mokkala, K., Gustafsson, J., Vahlberg, T., Plat, J., Laitinen, K.
  • Journal    :Nutrition, Metabolism and Cardiovascular Diseases
  • Year         :2022

Prof. Anca Oana Hermenean |Pharmacology |Best Innovation Award

Prof. Anca Oana Hermenean|Pharmacology |Best Innovation Award|

Prof. Anca Oana Hermenean at Vasile Goldis Western University of Arad, Romania

PROFILE  

scopus

Orcid

Early Academic Pursuits 📚

Prof. Dr. Anca Hermenean began her academic journey at Babes-Bolyai University of Cluj-Napoca, Romania, where she earned her Bachelor’s degree in Biology from 1989 to 1994. This foundational education set the stage for her extensive career in biochemistry and molecular biology. Her academic prowess continued to shine as she pursued a PhD in Biology from 1997 to 2003, focusing on electron microscopy, histopathology, and immunohistochemistry. This period of intense study was marked by rigorous research and a commitment to understanding the microscopic and molecular mechanisms underlying various biological processes.

Professional Endeavors 🏛️

Prof. Hermenean’s professional career is distinguished by her roles in academia and research management. Since 2010, she has served as a Professor at the Faculty of Medicine, Vasile Goldis Western University of Arad (VGWU), where she has made significant contributions to the fields of histology and cell biology. Her expertise in these areas is evidenced by her ongoing research and teaching responsibilities.

In 2016, Prof. Hermenean was appointed Director of the VGWU Doctoral Studies Council, a role in which she has overseen the management and strategic development of doctoral programs in Medicine and Biology. Her leadership extended further in 2017 when she joined the Faculty of Engineering in Foreign Languages at Politehnica University of Bucharest, contributing to the Master Program in Biomaterials for Tissue Engineering. She has taught various courses related to cell and tissue biology, tissue regeneration, and debilitating diseases of tissue.

In 2020, Prof. Hermenean became the Director of the Life Science Institute and Principal Investigator at the Institute of Life Sciences, VGWU. Here, she manages research projects and oversees activities in microscopy labs and the animal facility, reflecting her deep engagement in both research and administration.

Contributions and Research Focus 🔬

Prof. Hermenean’s research contributions are broad and impactful, focusing on several key areas:

  1. Histology and Histopathology: Her work in these fields explores the microscopic structure of tissues and the pathological changes associated with various diseases. This includes significant contributions to understanding how cellular and tissular alterations can affect health.
  2. Phytomedicine: Prof. Hermenean has researched the modulation of signal transduction pathways by phytochemicals, their molecular regulation of anti-inflammatory and anti-fibrotic responses, and their interactions with drugs and chemicals.
  3. Nanobiotechnology: She has been involved in the characterization of bio-interfaces and in vivo biocompatibility studies of nanomaterials. Her work includes assessing the interactions between nanomedicines and biological systems, as well as evaluating structural and ultrastructural toxicological effects.
  4. Regenerative Medicine: Prof. Hermenean’s research also covers tissue repair and regeneration pathways, focusing on molecular signals, growth factors, and the mechanisms of tissue regeneration.

Accolades and Recognition 🏆

Prof. Hermenean’s work has garnered significant recognition within the scientific community. She holds a habilitation in Biology, a postdoctoral qualification that allows her to supervise PhD candidates. Her research has led to numerous publications in peer-reviewed journals, with an H-index of 30 on Scopus and 34 on Google Scholar. Additionally, she has been awarded several patents for her innovations in pharmaceutical compositions and drug delivery systems, underscoring her contributions to practical and applied sciences.

Impact and Influence 🌍

Prof. Hermenean’s influence extends beyond her research and teaching. Her roles in managing research councils and institutes highlight her ability to shape research strategies and educational programs. Her contributions have had a tangible impact on the advancement of biomedical sciences, particularly in the fields of histology, nanobiotechnology, and regenerative medicine.

Her work on phytomedicine and nanobiotechnology is particularly notable for its potential applications in developing new therapeutic approaches and improving existing medical treatments. Her patents and research projects reflect her commitment to translating scientific discoveries into practical solutions.

Legacy and Future Contributions 🔮

Prof. Hermenean’s legacy is marked by her dedication to advancing scientific knowledge and training the next generation of researchers. Her leadership in establishing and managing research infrastructures, such as the animal facility and microscopy labs at VGWU, demonstrates her commitment to fostering a supportive environment for cutting-edge research.

Looking ahead, Prof. Hermenean is poised to continue making significant contributions to her fields of expertise. Her ongoing research and collaborations are expected to yield further advancements in phytomedicine, nanobiotechnology, and regenerative medicine. Her role as a mentor and educator will also play a crucial part in shaping future research and development in these areas.

🎓Publication 

Chrysin-loaded calixarene-cyclodextrin ternary drug delivery system inhibits TGF-β and galectin-1 mediated pathways in diabetic liver

  • Authors   :Balta, C., Herman, H., Ciceu, A., D’Amico, M., Hermenean, A..
  • Journal    :Biochemical Pharmacology
  • Year         :2024

Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice

  • Authors   :Wang, S., Yu, X., Cheng, L., Lu, Y., Wu, X..
  • Journal    :Cell Death and Disease
  • Year         :2024

Exploring In Vivo Pulmonary and Splenic Toxicity Profiles of Silicon Quantum Dots in Mice

  • Authors   :Cristian, R.-E., Balta, C., Herman, H., Dinischiotu, A., Stan, M.S..
  • Journal    :Materials.
  • Year         :2024

Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system

Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems

  • Authors   :Herman, H., Rata, D.M., Cadinoiu, A.N., Atanase, L.I., Hermenean, A..
  • Journal    :Polymers
  • Year         :2024