Fabrizio Carta | Medicinal Chemistry | Pharmaceutical Research Excellence Award

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Prof. Fabrizio Carta | Medicinal Chemistry | Pharmaceutical Research Excellence Award

Universita’ degli Studi di di Firenze | Italy

Prof. Fabrizio Carta is an accomplished medicinal chemist and academic leader whose research bridges rational drug design, molecular pharmacology, and structure–activity relationship analysis to address critical unmet medical needs. As an Associate Professor of Medicinal Chemistry at the University of Florence, within the Department of Neuroscience, Psychology, Drug Area and Child Health (NEUROFARBA), he has established an internationally recognized research profile centered on the discovery and optimization of innovative bioactive compounds of both natural and synthetic origin. His scientific vision integrates chemical creativity with biological insight, enabling the development of next-generation therapeutic agents with improved selectivity, efficacy, and safety profiles.His research activity spans three interconnected domains. The first focuses on the rational design and synthesis of novel small molecules targeting challenging disease pathways, with particular emphasis on antiglaucoma, anti-obesity, anticancer, and antiviral agents. The second domain is dedicated to the in-depth molecular characterization of biological activity and mechanisms of action, combining chemical synthesis, biochemical evaluation, and pharmacological validation to uncover new drug targets and signaling pathways. The third domain involves advanced structure–activity relationship studies, often supported by structural biology data, to guide structure-based optimization and minimize off-target effects.A major hallmark of Prof. Carta’s work is his pioneering contribution to the field of carbonic anhydrase modulation. As principal investigator or co-investigator on multiple funded projects, he has designed and synthesized a broad spectrum of carbonic anhydrase inhibitors and modulators belonging to diverse chemical classes, including sulfonamides, sulfamides, sulfamates, carboxylic acids, coumarins, polyamines, phenols, dithiocarbamates, xanthates, and monothiocarbamates. Notably, he contributed to the discovery of entirely new inhibitor classes, significantly expanding the chemical space of zinc-binding motifs and influencing subsequent drug discovery efforts. His work also played a key role in the development of a clinically advanced carbonic anhydrase IX inhibitor for the management of hypoxic tumors.

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Jean Noël Nyemb | Medicinal Chemistry | Editorial Board Member

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Assist. Prof. Dr. Jean Noël Nyemb | Medicinal Chemistry | Editorial Board Member

The University of Maroua | Cameroon

Assist. Prof. Dr. Jean Noël Nyemb is a distinguished Cameroonian scholar in Organic Chemistry, widely recognized for his contributions to natural products chemistry, medicinal chemistry, and applied chemical sciences. He serves as a Senior Lecturer in the Department of Refining and Petrochemistry at the National Advanced School of Mines and Petroleum Industries, University of Maroua, where he plays a leading role in teaching, research, postgraduate supervision, and curriculum development. Over the course of his academic journey, he has held several positions across respected higher education institutions, including the University of Maroua, the University of Ngaoundere, and the Higher Institute of Science and Technology of Yaounde. His progressive career includes roles as Instructor, Lecturer, Part-time Lecturer, Research Fellow, and ultimately Senior Lecturer, reflecting a consistent record of academic excellence, professional growth, and dedication to scientific advancement.Dr. Nyemb earned his Ph.D. in Organic Chemistry with the highest distinction, specializing in Natural Products Chemistry, following a strong academic foundation that includes graduate and undergraduate degrees in Organic and Applied Chemistry. His scientific expertise covers the isolation, characterization, and structural elucidation of secondary metabolites, the synthesis and semi-synthesis of biologically active compounds, and the evaluation of their pharmacological potential, including antimicrobial, antioxidant, enzyme-inhibitory, and chemotaxonomic relevance. His research further integrates molecular docking, computational drug design, pharmacokinetics, toxicology, enzymology, and biochemistry, illustrating his multidisciplinary approach to discovering bioactive molecules with therapeutic value.With more than forty publications, an impressive cumulative impact factor, and numerous articles as principal or co-author, Dr. Nyemb has established himself as a productive scientist in his field. His works span areas such as phytochemical profiling, medicinal plant research, natural compound synthesis, and biological activity evaluation. His publications are well-cited globally, and his h-index reflects strong scholarly influence. Dr. Nyemb is also actively involved in ongoing research projects focusing on bioactive compounds from Vernonia species and members of the Zingiberaceae family, highlighting his interest in medicinal plants and ethnopharmacological resources.

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Karanvir Singh | Medicinal Chemistry | Best Researcher Award

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Mr. Karanvir Singh | Medicinal Chemistry | India

Guru Nanak Dev University | India

Mr. Karanvir Singh is a dynamic and highly skilled researcher in the field of pharmaceutical chemistry, currently pursuing his Doctorate of Philosophy at the Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India. His ongoing doctoral research, under the supervision of Prof. Dr. Preet Mohinder Singh Bedi, focuses on the design and synthesis of 1,2,4-triazine hybrids with Nipecotic acid for anticonvulsant activity, emphasizing computational modeling, synthesis, and biological evaluation of novel anticonvulsant agents. He holds a Master’s degree in Pharmacy (Pharmaceutical Chemistry) from ISF College of Pharmacy, Moga, Punjab, where he completed a thesis on the design and synthesis of 1,2,4-triazine derivatives for anticonvulsant activity under the guidance of Dr. Vikramdeep Monga and Dr. Bhupinder Kumar. His strong academic foundation was built upon a Bachelor of Pharmacy from the Laureate Institute of Pharmacy, Himachal Pradesh.With a blend of academic excellence and industrial exposure, Mr. Singh has worked as an Assistant QA Chemist at United Biotech Pvt. Ltd., where he gained extensive experience in pharmaceutical quality assurance. His scientific expertise spans molecular docking, fragment-based drug design, pharmacophore modeling, molecular dynamics simulations, organic synthesis, compound purification, and structural elucidation using analytical tools such as NMR, FT-IR, HPLC, and Mass spectrometry.Mr. Singh has made significant contributions to the scientific community, authoring multiple research and review articles in reputed journals. His notable publications include Design, Synthesis, and Biological Evaluation of Triazole-Linked Lignan–Monoterpenoid-Based Hybrid Molecules as Xanthine Oxidase Inhibitors with Potent In Vivo Efficacy; Design, Synthesis, and Multi-Target Biological Evaluation of 1,2,3-Triazole Linked Indole–Thiazolidinedione Hybrids as Potent α-Glucosidase, α-Amylase, and DPP-4 Inhibitors with Antioxidant Potential; Design, Synthesis, Antibacterial Evaluation, and Molecular Modelling Studies of 1,2,3-Triazole-Linked Coumarin–Vanillin Hybrids as Potential DNA Gyrase and Topoisomerase IV Inhibitors; and Development of Coumarin-Inspired Bifunctional Hybrids as a New Class of Anti-Alzheimer’s Agents with Potent In Vivo Efficacy. His review works, such as Exploring Norfloxacin Analogs in Combating Antimicrobial Resistance: Design, Mechanistic Insights, and Structure–Activity Relationship and Incredible Indolinedione Derivatives Nucleus in the Development of Anti-Diabetic Drugs: Exploring the Mechanistic Studies, Design, and Structure–Activity Relationship, further demonstrate his broad research vision and scientific depth.

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Featured Publications

Singh, K., Pal, R., Khan, S. A., Kumar, B., & Akhtar, M. J. Insights into the structure–activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review. Journal of Molecular Structure.

Singh, A., Malhotra, D., Singh, K., Chadha, R., & Bedi, P. M. S. Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure–activity relationship, and pharmacological outcomes. Journal of Molecular Structure.

Singh, A., Singh, K., Sharma, A., Kaur, K., Kaur, K., Chadha, R., & Bedi, P. M. S. Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight. Journal of Molecular Structure.

Pal, R., Singh, K., Khan, S. A., Chawla, P., Kumar, B., & Akhtar, M. J. Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction. European Journal of Medicinal Chemistry.

Singh, A., Singh, K., Sharma, A., Kaur, K., Chadha, R., & Bedi, P. M. S. Recent advances in antifungal drug development targeting lanosterol 14α-demethylase (CYP51): A comprehensive review with structural and molecular insights. Chemical Biology & Drug Design.