Hui Xiao | Drug Discovery and Development | Pharmaceutical Innovation Achievement Award

Hui Xiao | Drug Discovery and Development | Pharmaceutical Innovation Achievement Award

Dr Hui Xiao,regeneron,United States

Dr. Hui Xiao 🧪🔬 is a distinguished scientist specializing in biochemistry, structural biology, and mass spectrometry. With a strong focus on microtubule dynamics, protein interactions, and drug mechanisms, he has made significant contributions to understanding cellular processes. As a co-first author and lead researcher, his work has been published in esteemed journals like J. Mol. Biol., Biochemistry, and J. Biol. Chem.. His expertise spans hydrogen-deuterium exchange, proteomics, and molecular stabilization studies. Dr. Xiao’s research has advanced drug discovery, particularly in cancer therapeutics and protein biochemistry. 📚🔍 His innovative approaches continue to impact biomedical sciences globally. 🌍✨

Publication Profile

Scopus

Education

Dr. Hui Xiao 🎓 holds a Ph.D. in Analytical Chemistry from the University of Massachusetts, Amherst (2005) and a degree in Applied Chemistry from Peking University, China (1992). Currently serving as an Associate Director at Regeneron Pharmaceuticals 🏢, he specializes in protein characterization using mass spectrometry. With over a decade at Regeneron, he has progressed through roles as a Senior Staff Scientist and Staff Scientist. Previously, he held academic positions at Albert Einstein College of Medicine 🧬, advancing from Instructor to Research Associate Professor. His expertise spans analytical chemistry, protein analysis, and therapeutic protein research, making significant contributions to biomedical science. 🔬

Professional Impact

Dr. Hui Xiao 🎓 is a distinguished scientist with over 20 years of experience in academia and the biotechnology industry. Currently, he serves as an Associate Director of Analytical Chemistry at Regeneron Pharmaceuticals 🏢, a leading biotech company. His expertise lies in mass spectrometry applications for protein characterization 🔬, contributing to advancements in therapeutic development. Before joining Regeneron, Dr. Xiao held esteemed faculty positions at Albert Einstein College of Medicine 🧬, progressing from Instructor to Research Associate Professor. His extensive research and leadership have played a crucial role in bridging analytical chemistry with biopharmaceutical innovation, impacting drug discovery and development. 🚀

Scientific Contributions

Dr. Hui Xiao 🎓 is a leading expert in protein-ligand interactions, structural proteomics, and therapeutic protein analysis 🔬. His pioneering work includes the application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) for epitope mapping 🧩 and microtubule stabilization research. With a deep focus on drug characterization and regulatory sciences, his contributions have significantly advanced biopharmaceutical development 💊. His expertise in mass spectrometry-driven protein analysis has helped enhance the understanding of molecular mechanisms, improving therapeutic strategies. Through innovation and research, Dr. Xiao continues to play a vital role in shaping the future of biopharmaceutical science and drug discovery. 🚀

Potential Considerations

Dr. Hui Xiao 🎓 is a renowned expert in analytical and protein chemistry, with groundbreaking work in epitope mapping and protein characterization 🔬. While his contributions significantly impact drug development, the Pharmaceutical Innovation Achievement Award 🏆 may prioritize direct advancements in drug discovery and novel pharmaceutical interventions 💊. His research has important regulatory and therapeutic implications, but highlighting specific drug innovations or regulatory breakthroughs he has led would further strengthen his case. By showcasing his role in pioneering pharmaceutical advancements, Dr. Xiao’s influence in shaping modern biopharmaceutical science can be fully recognized and appreciated. 🚀

Research Focus

Dr. Hui Xiao’s research primarily focuses on analytical chemistry 🧪, particularly in the quantitative analysis of biomolecules 🧬 using advanced mass spectrometry techniques ⚖️. His work involves CRISPR sgRNA modification analysis 🧬🔬 and the development of LC-MS-based assays for biological therapeutics 💊. He specializes in phosphorothioate isomer detection 🔄 and liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) 📊 for precise biomolecular quantification. His contributions are crucial in drug discovery 🏥, gene editing 🧬, and biopharmaceutical development 💉. His expertise bridges biotechnology 🔬 and analytical methodologies 📈, advancing innovations in therapeutic monitoring and molecular diagnostics 🏥.

Publication Top Notes

Quantitative Analysis of Phosphorothioate Isomers in CRISPR sgRNA at Single-Residue Resolution Using Endonuclease Digestion Coupled with Liquid Chromatography Cyclic Ion Mobility Mass Spectrometry (LC/cIMS)

Generic Enrichment Method for Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Biological Therapeutics in Serum

Shanthi Veerappapillai | Drug Discovery and Development | Best Researcher Award

Shanthi Veerappapillai | Drug Discovery and Development | Best Researcher Award

Dr Shanthi Veerappapillai, Vellore Institute of Technology, India

Dr. Shanthi Veerappapillai is a distinguished Professor at VIT University, specializing in Bioinformatics and Computational Biology. With a Ph.D. from VIT, her research interests include computational protein analysis, drug resistance studies, and virtual screening, particularly focusing on infectious diseases like HIV and tuberculosis. She has led multiple funded research projects and published over 130 peer-reviewed articles. Dr. Veerappapillai has been recognized with awards like the Women Achiever Award for Sponsored Research Excellence (2020) and has supervised numerous Ph.D. graduates. Her dedication to education and research is also reflected in her active participation in conferences and professional societies. 👩‍🔬📚💻🌍

Publication Profile

Google Scholar

Education Qualification

Dr. Shanthi Veerappapillai holds a Ph.D. in Bioinformatics from VIT University, Tamil Nadu, India, and an M.Tech in Chemical Process and Design from SASTRA University, Tamil Nadu, India. She also earned a B.Tech in Chemical Engineering from EGS Pillai Engineering College, Bharathidasan University, Tamil Nadu, India. With a strong foundation in both chemical engineering and bioinformatics, Dr. Veerappapillai brings a multidisciplinary approach to her research and academic work. Her diverse academic background equips her with the expertise to bridge the gap between technology and biology, contributing to advancements in various scientific fields. 🧬⚙️🎓

Leadership in Research

Dr. Shanthi Veerappapillai is a dedicated scientist with extensive leadership experience as Principal Investigator (PI) in multiple prominent projects. Her research spans critical areas such as drug repurposing strategies and cancer research, showcasing her expertise in advancing both medical and computational biology. Through her work, she has contributed significantly to the development of innovative therapeutic approaches, emphasizing her commitment to enhancing healthcare and medical research. Her ability to lead and collaborate on large-scale projects underscores her impact in the field, making her a valuable asset in shaping the future of medical science and computational biology. 🧬🔬💊

Mentorship and Teaching

Dr. Shanthi Veerappapillai is a distinguished academic with vast experience in supervising successful Ph.D. candidates and teaching specialized subjects in biotechnology and bioinformatics. Her dedication to fostering academic development is evident in her role as a mentor to future researchers. With a passion for guiding students through advanced research topics, she has contributed significantly to shaping the next generation of experts in her field. Her work in biotechnology and bioinformatics continues to inspire students, encouraging innovation and critical thinking in these dynamic disciplines. 👩‍🔬📚🎓🔬👩‍💻

Community Engagement

Dr. Shanthi Veerappapillai is a dedicated academician who has made significant contributions to the scientific community through her active involvement in organizing conferences and workshops. As a member of various professional bodies, Dr. Veerappapillai continuously strengthens her presence in the academic world, sharing her expertise and collaborating with fellow researchers. Her commitment to advancing knowledge and fostering professional connections has had a lasting impact on her field. With a focus on promoting growth in the academic and scientific community, Dr. Veerappapillai’s efforts continue to inspire others. 🌍🧑‍🏫📚

Awards and Achievement

Dr. Shanthi Veerappapillai is a distinguished researcher with 131 peer-reviewed journal articles and an H-index of 14. She received the Best Chapter Award from BRSI-VIT for her exceptional contributions in 2023. She was honored with the Women Achiever Award for Sponsored Research Excellence in 2020 and has been a Research Fellow at INTI International University, Malaysia since June 2023. Dr. Veerappapillai’s academic journey includes producing 100% results in Chemical Engineering Thermodynamics courses and securing university ranks and prizes for academic excellence. She has also received several accolades, including a Best Poster Presentation Award at VIT University. 🏆📚👩‍🔬🌟

Research Focus

Dr. V. Shanthi’s research primarily focuses on molecular simulation, bioinformatics, and computational approaches to drug discovery. She has explored mechanisms of drug resistance, particularly in influenza virus neuraminidase, using molecular simulations to understand oseltamivir resistance. Her work also spans polypharmacology, investigating therapeutic agents for non-small cell lung cancer, and the identification of potential inhibitors for various viruses like H5N1. Additionally, she has contributed to bioprocess industry applications, drug repurposing, and plant-based therapeutic compounds. Her research aims at enhancing drug design, discovering novel therapeutic agents, and understanding the molecular interactions that govern drug efficacy. 🔬💊🦠💡

Publication Top Notes

Exploring the cause of oseltamivir resistance against mutant H274Y neuraminidase by molecular simulation approach

Current progress and future perspectives of polypharmacology: From the view of non-small cell lung cancer

Bioactive Amento flavone isolated from Cassia fistula L. leaves exhibits therapeutic efficacy

Application of heat exchangers in bioprocess industry: a review

Multi-dimensional screening strategy for drug repurposing with statistical framework—a new road to influenza drug discovery

Identification of potential inhibitors of H5N1 influenza A virus neuraminidase by ligand-based virtual screening approach

Role of the cation-π interaction in therapeutic proteins: A comparative study with conventional stabilizing forces

 

 

 

Prof. Rasha Azzam|Drug Discovery and Development|Best Researcher Award

Prof. Rasha Azzam|Drug Discovery and Development |Best Researcher Award

Prof. Rasha Azzam at Helwan University,Egypt

PROFILE  

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Early Academic Pursuits 🎓

Prof. Rasha A. Azzam’s academic journey began with her outstanding performance in chemistry at Helwan University, Egypt, where she graduated with a Bachelor of Science (B.Sc.) in Chemistry in 1993. Her excellence in academia was recognized early on, as she graduated with class honors and was placed on the Dean’s List. Driven by her passion for organic chemistry, she pursued a Master of Science (M.Sc.) degree in Organic Chemistry at Helwan University, completing it in 1996. Her academic curiosity and dedication led her to further her studies internationally, earning a prestigious Ph.D. in Organic Chemistry in 2003 from the Catholic University of Leuven in Belgium. Her diverse educational background laid the foundation for a career defined by groundbreaking research and academic excellence.

Professional Endeavors 🧑‍🔬

Prof. Azzam’s professional career spans over two decades of teaching, research, and leadership in various prestigious academic institutions across the globe. She is currently a Professor of Organic Chemistry at the Faculty of Science, Helwan University, where she has been contributing since 2021. Prior to this, she held the position of Associate Professor of Organic Chemistry at the same institution from 2016 to 2021, demonstrating her upward trajectory in academia.

Her teaching and research influence extended beyond Egypt. She has held positions as an Associate Professor at Taibah University in Saudi Arabia, Nigerian Turkish Nile University in Nigeria, and the American University in Nigeria, where she was a co-founder of the Petroleum Chemistry Program. Additionally, she has served as a Visiting Professor at Virginia Commonwealth University in 2024, further showcasing her international academic reach.

Contributions and Research Focus 🔬

Prof. Azzam’s research focuses on organic and medicinal chemistry, with a particular emphasis on green synthesis, nanomaterials, and antiviral agents. One of her key research interests is the development of new methods for synthesizing compounds with potential anticancer and antimicrobial properties. Her recent project, “Synthesis of new sulfa derivatives under ultrasonic irradiation as potential anticancer/antimicrobial agents,” funded by Helwan University in 2021, highlights her innovative approach to organic synthesis.

Prof. Azzam’s work also explores environmentally friendly technologies, as demonstrated by her research on “green technology based on nanoporous biodegradable polymeric membranes” for wastewater treatment, funded by the Academy of Scientific Research Technology (ASRT). She has also conducted pioneering work on nanomaterials and their applications in industrial processes, such as her research on thermoplastic elastomers based on petrochemicals and the development of anti-COVID-19 agents incorporated into nanofibrous mats.

Her research output is extensive, and she has presented several projects on global platforms, including her work on antiviral therapeutic agents and nanomaterials. Her research contributions are shaping the future of organic chemistry, particularly in the domains of green chemistry and medical applications.

Accolades and Recognition 🏆

Prof. Azzam’s excellence in research and community service has been recognized through numerous awards and honors. In 2023, she received the prestigious Prince Mohammed Bin Fahd Scientific Award for her contributions to scientific production that serves community development within the framework of sustainable development goals. In the same year, she was honored with Helwan University’s Outstanding Scientific Achievement Award in Basic and Applied Sciences.

She has also been recognized for her mentoring and supervision of students, receiving Best Master Thesis Awards for two of her master’s students, Rasha Essam (2020) and Heba Elboshi (2023). Her commitment to advancing research was further acknowledged when she received the Research Excellence Awards for her students, Rokia Ramadan (2019) and Rasha Essam (2020). Additionally, Prof. Azzam was awarded a Silver Medal from the Academy of Scientific Research Technology (ASRT) in 2018 for her outstanding contributions to science.

Her impact extends internationally, with her receiving the Outstanding Faculty Member Award from the American University in Nigeria in 2007, and a research scholarship from the Catholic University of Leuven in 2001.

Impact and Influence 🌍

Prof. Azzam’s influence is felt not only through her research but also through her active participation in the scientific community. She serves as a Review Editor for Organic Chemistry on the Editorial Board of Frontiers in Chemistry and as an editor for the Journal of Chemistry and The Scientific World Journal, both published by Hindawi. She is also a grant evaluator for the Fulbright Binational Scholarship Program, where she helps assess the next generation of academic leaders.

Her commitment to education and community service is reflected in her involvement in organizing training workshops for high school teachers and instructing lab sessions for the AUN Community School. Prof. Azzam is also a member of the Egyptian Society for Basic Sciences, where she contributes to the development of the scientific community in Egypt.

Legacy and Future Contributions 🌟

Prof. Rasha A. Azzam’s legacy is built on her unwavering dedication to advancing organic chemistry, fostering academic excellence, and mentoring the next generation of scientists. Her research has laid the groundwork for significant developments in green chemistry, nanomaterials, and medicinal chemistry. With her continued focus on innovative solutions for pressing global challenges, such as wastewater treatment and the development of antiviral agents, she is poised to make even more impactful contributions in the years to come.

🎓Publication 

In the pursuit of novel therapeutic agents: synthesis, anticancer evaluation, and physicochemical insights of novel pyrimidine-based 2-aminobenzothiazole derivatives

  • Authors   :Toka I. Ismail; Nashwa El-Khazragy; Rasha A. Azzam
  • Journal    :RSC Advances
  • Year         :2024

Novel High-Performance Functionalized and Grafted Bio-Based Chitosan Adsorbents for the Efficient and Selective Removal of Toxic Heavy Metals from Contaminated Water

  • Authors   :Mohammad Monir; Rasha E. Elsayed; Rasha Azzam; Tarek M. Madkour
  • Journal    :Polymers
  • Year         :2024

Crystal structure of 4-(benzo[d]thiazol-2-yl)-1,2-dimethyl-1H-pyrazol-3(2H)-one

  • Authors   :Heba A. Elboshi; Rasha A. Azzam; Galal H. Elgemeie; Peter G. Jones
  • Journal    :Acta Crystallographica Section E Crystallographic Communications
  • Year         :2024

Synthesis of New Guanidine Benzothiazole Derivative and Its Application as Eco-Friendly Corrosion Inhibitor

  • Authors   : Abdel-karim, Amal M.; Azzam, Rasha A.; Shehata, Omnia S.; Adly, Mohamed A.; El-Shamy, Omnia A. A.; El-Mahdy, Gamal A.
  • Journal    :Chemistry
  • Year         :2023

Crystal structure of 2-{[5-(methylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-yl]methyl}benzo[d]thiazole

  • Authors   : Rasha A. Azzam; Galal H. Elgemeie; Heba A. Elboshi; Peter G. Jones
  • Journal    :Crystallographica Section E Crystallographic Communications
  • Year         :2023