Fabrizio Carta | Medicinal Chemistry | Pharmaceutical Research Excellence Award

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Prof. Fabrizio Carta | Medicinal Chemistry | Pharmaceutical Research Excellence Award

Universita’ degli Studi di di Firenze | Italy

Prof. Fabrizio Carta is an accomplished medicinal chemist and academic leader whose research bridges rational drug design, molecular pharmacology, and structure–activity relationship analysis to address critical unmet medical needs. As an Associate Professor of Medicinal Chemistry at the University of Florence, within the Department of Neuroscience, Psychology, Drug Area and Child Health (NEUROFARBA), he has established an internationally recognized research profile centered on the discovery and optimization of innovative bioactive compounds of both natural and synthetic origin. His scientific vision integrates chemical creativity with biological insight, enabling the development of next-generation therapeutic agents with improved selectivity, efficacy, and safety profiles.His research activity spans three interconnected domains. The first focuses on the rational design and synthesis of novel small molecules targeting challenging disease pathways, with particular emphasis on antiglaucoma, anti-obesity, anticancer, and antiviral agents. The second domain is dedicated to the in-depth molecular characterization of biological activity and mechanisms of action, combining chemical synthesis, biochemical evaluation, and pharmacological validation to uncover new drug targets and signaling pathways. The third domain involves advanced structure–activity relationship studies, often supported by structural biology data, to guide structure-based optimization and minimize off-target effects.A major hallmark of Prof. Carta’s work is his pioneering contribution to the field of carbonic anhydrase modulation. As principal investigator or co-investigator on multiple funded projects, he has designed and synthesized a broad spectrum of carbonic anhydrase inhibitors and modulators belonging to diverse chemical classes, including sulfonamides, sulfamides, sulfamates, carboxylic acids, coumarins, polyamines, phenols, dithiocarbamates, xanthates, and monothiocarbamates. Notably, he contributed to the discovery of entirely new inhibitor classes, significantly expanding the chemical space of zinc-binding motifs and influencing subsequent drug discovery efforts. His work also played a key role in the development of a clinically advanced carbonic anhydrase IX inhibitor for the management of hypoxic tumors.

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Ali Darehkordi | Medicinal Chemistry | Research Excellence Award

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Prof. Dr. Ali Darehkordi | Medicinal Chemistry | Research Excellence Award

Vali-e-Asr University of Rafsanjan | Iran

Prof. Dr. Ali Darehkordi is a distinguished Iranian chemist whose academic and professional career reflects deep expertise in organic synthesis, catalysis, drug modification, heterocyclic chemistry, and the design of biologically active fluorinated compounds. He holds a Ph.D., M.Sc., and B.Sc. in Organic Chemistry and Chemistry from leading Iranian universities, with a strong foundational background in natural sciences. Beginning his academic journey as an instructor in the Faculty of Science at Vali-e-Asr University of Rafsanjan, he steadily advanced through key academic ranks, serving as Assistant Professor, Associate Professor, and ultimately Professor of Organic Chemistry. Throughout his career, he has also held several important administrative and leadership roles, including Deputy of the Faculty of Science, Director of the Department of Chemistry, and repeated appointments as Head of the Faculty of Basic Sciences, where he contributed to academic development, departmental management, curriculum enhancement, and research advancement.Prof. Darehkordi’s research accomplishments have earned him multiple awards, including several Excellent Researcher Awards at the faculty, departmental, and university levels, recognizing his contributions to both scientific research and industrial collaboration. His scientific interests span a wide range of advanced topics, such as the design, synthesis, and biological evaluation of trifluoromethylated heterocyclic compounds with anticancer potential, catalysis reactions, drug modification using trifluoroacetimidoyl chlorides, organic synthesis pathways, carbohydrate reaction mechanisms, and herbal medicine applications. His laboratory expertise includes hands-on proficiency with NMR, FT-IR, microwave reactors, ultrasound systems, and polarimetry, supporting his ability to conduct complex chemical characterizations and innovative synthesis techniques.As an active researcher with extensive contributions to international journals, Prof. Darehkordi has authored impactful publications, including A novel bistrifluoromethylated compound as highly efficient nematicide against root-knot nematode on pistachio and docking study, Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies, and A facile and catalyst-free microwave-promoted method for the synthesis of 3-trifluoromethyl 1,2,4-triazole-5-thiones. These publications highlight his innovative chemical synthesis approaches, application-driven research mindset, and strong integration of computational docking, biological testing, and modern reaction methodologies. Prof. Dr. Ali Darehkordi continues to stand as a leading scientist in organic and medicinal chemistry, contributing meaningfully to drug discovery, reaction design, and fluorinated molecule development.

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Featured Publications

Moghadam, M. R., Jahromi, S. M. P., & Darehkordi, A. (2016). Simultaneous spectrophotometric determination of copper, cobalt, nickel and iron in foodstuffs and vegetables with a new bis thiosemicarbazone ligand using chemometric approaches. Food Chemistry, 192, 424–431.

Darehkordi, A., Saidi, K., & Islami, M. R. (2007). Preparation of heterocyclic compounds by reaction of dimethyl and diethyl acetylene dicarboxylate (DMAD, DEAD) with thiosemicarbazone derivatives. Arkivoc, 1, 180–188.

Darehkordi, A., Rahmani, F., & Hashemi, V. (2013). Synthesis of new trifluoromethylated indole derivatives. Tetrahedron Letters, 54(35), 4689–4692.

Funt, L. D., Tomashenko, O. A., Novikov, M. S., & Khlebnikov, A. F. (2018). An azirine strategy for the synthesis of alkyl 4-amino-5-(trifluoromethyl)-1H-pyrrole-2-carboxylates. Synthesis, 50(24), 4809–4822.

Karimabad, M. N., Mahmoodi, M., Jafarzadeh, A., Darehkordi, A., Hajizadeh, M. R., et al. (2017). The novel Indole-3-formaldehyde (2-AITFEI-3-F) is involved in processes of apoptosis induction? Life Sciences, 181, 31–44.

Karimabad, M. N., Mahmoodi, M., Jafarzadeh, A., Darehkordi, A., Hajizadeh, M. R., et al. (2017). Evaluating of OCT-4 and NANOG was differentially regulated by a new derivative indole in leukemia cell line. Immunology Letters, 190, 7–14.