The foundation of the research on Bacillus clausii and its novel delivery systems traces back to early academic pursuits in microbiology and biotechnology. Researchers embarked on this journey by gaining extensive knowledge in microbial physiology, genetics, and the complex interactions between probiotics and the human gut microbiome. This academic groundwork was crucial in understanding the significance of Bacillus clausii as a robust probiotic strain capable of withstanding harsh gastrointestinal conditions.

🧪Professional Endeavors :

Professional endeavors in this field have seen a significant focus on the development and optimization of microencapsulation techniques. Scientists and researchers dedicated their efforts to creating advanced delivery systems that protect probiotics from the acidic environment of the stomach and ensure their controlled release in the intestines. This involved interdisciplinary collaborations between microbiologists, food scientists, and biotechnologists, who worked together to design and test various non-digestible carbohydrate formulations. These endeavors were aimed at enhancing the stability, viability, and efficacy of Bacillus clausii in probiotic supplements and functional foods.

🔬Contributions and Research Focus :

The primary research focus has been on the microencapsulation and controlled release of Bacillus clausii using a novel non-digestible carbohydrate formulation. This approach leverages the protective properties of non-digestible carbohydrates, such as inulin, resistant starch, and pectin, to encapsulate the probiotic cells. The encapsulation process involves techniques like spray drying, freeze-drying, and extrusion, which help in forming a protective matrix around the probiotic cells. The key contributions of this research include:

• Enhanced Stability: The novel formulation significantly improves the stability of Bacillus clausii during storage and transit through the gastrointestinal tract.
• Controlled Release: The non-digestible carbohydrate matrix ensures a controlled and sustained release of the probiotics in the intestines, maximizing their beneficial effects.
• Improved Efficacy: The formulation enhances the colonization and activity of Bacillus clausii in the gut, leading to better health outcomes for the host.

🏆Accolades and Recognition :

The groundbreaking work on the microencapsulation and controlled release of Bacillus clausii has garnered significant accolades and recognition in the scientific community. Researchers involved in this project have been awarded prestigious grants and honors for their innovative contributions to probiotic delivery systems. Notable achievements include:

• Best Research Paper Award: The research paper detailing the novel formulation received the best research paper award at several international microbiology and biotechnology conferences.
• Patent Grants: Multiple patents have been granted for the unique encapsulation techniques and formulations developed during the course of this research.
• Industry Collaborations: Leading biotechnology and pharmaceutical companies have recognized the potential of this technology and established collaborations to commercialize the probiotic delivery systems.

🌍Impact and Influence :

The impact and influence of this research extend beyond academic circles, affecting various sectors including healthcare, nutrition, and the food industry. The novel non-digestible carbohydrate formulation has revolutionized probiotic delivery, leading to:

• Improved Gut Health: The enhanced delivery system ensures that Bacillus clausii effectively colonizes the gut, contributing to improved digestive health, immune function, and overall well-being.
• Commercial Products: Several probiotic supplements and functional foods incorporating this technology have been successfully launched in the market, providing consumers with more effective probiotic solutions.
• Research Advancements: The success of this research has inspired further studies into microencapsulation and controlled release technologies for other probiotic strains and bioactive compounds.

🌟Legacy and Future Contributions :

The legacy of this research lies in its transformative approach to probiotic delivery, setting a new standard for efficacy and stability in the field. Future contributions are poised to expand on this foundation, exploring:

• Personalized Probiotic Therapies: Tailoring probiotic formulations to individual microbiome profiles for personalized health benefits.
• Multi-Strain Encapsulation: Developing encapsulation techniques for multiple probiotic strains to create synergistic effects and enhance gut health.

🎓Publication 

Prof Dr. ASHOK KUMAR SHAKYA ,Drug Discovery and Development ,Best Researcher Award

Prof Dr. ASHOK KUMAR SHAKYA, at AL-AHLIYYA AMMAN UNIVERSITY ,Jordan

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🎓Early Academic Pursuits

Prof. Dr. Ashok K. Shakya’s academic journey began at Dr. Harisingh Gour University, Sagar (A Central University), India. He earned his Bachelor of Science in 1986, followed by a Master of Pharm. Science in 1988. His academic excellence continued as he pursued a Ph.D. in Pharmaceutical Sciences, which he completed in 1992. His doctoral research focused on the “Synthesis and Pharmacological Evaluation of Some 1:3:4 Thiadiazole Derivatives,” where he synthesized various thiadiazole derivatives and evaluated their pharmacological activities, including CNS depressant, anti-inflammatory, hypotensive, and diuretic effects.

Professional Endeavors

Dr. Shakya’s professional career spans over three decades, marked by significant contributions to pharmaceutical education and research. He began his teaching career as an Assistant Professor at Dr. Harisingh Gour University in 1988. He later held positions at Integral University, Lucknow, India, where he served as the Head of the Faculty of Pharmacy and contributed to establishing Master’s and Ph.D. programs.

In 1995, Dr. Shakya joined Ranbaxy Research Laboratories as a Manager in the Division of Clinical Pharmacology, Pharmacokinetics & Drug Metabolism. Here, he developed and validated various analytical methods for new and existing drug molecules, playing a crucial role in clinical studies (PK/BE/BA).

Since 2008, Dr. Shakya has been associated with Al-Ahliyya Amman University, Jordan. He served as an Assistant Professor, Associate Professor, and currently as a Professor in the Faculty of Pharmacy. He has been instrumental in teaching, research, and curriculum development. His administrative roles include Vice Dean of University Scientific Research and Assistant Dean of PDRC, where he established state-of-the-art research facilities and promoted research collaborations.

Contributions and Research Focus

Dr. Shakya’s research expertise encompasses Medicinal Chemistry, Pharmaceutical Analysis, Phytopharmaceuticals, Formulation Development, and Peptide Synthesis. He has developed several analytical and bioanalytical techniques for new chemical entities (NCE), investigational new drugs (IND), and abbreviated new drug applications (ANDA). His contributions include establishing GLP-compliant animal houses and staying abreast of current trends in cGMP, cGCP, and Good Laboratory Practices.

Dr. Shakya has filed two patents on anticancer and antitubercular agents. His skills extend to various analytical techniques, including LCMSMS, GC-MSMS, UPLC, and molecular modeling. He has also synthesized peptides and peptidomimetics, contributing to the field of drug design and discovery.

Accolades and Recognition

Dr. Shakya’s work has been recognized at numerous international conferences. He has presented his research at prestigious events such as the Eurasia Pharmacy Conference in Turkey, the International Conference on New Trends in Chemometrics and Applications in Turkey, and the Propolis-Human and Bee Health Conference in Bulgaria. His keynote address at the Best Med Grape conference in Beirut, Lebanon, highlights his standing in the scientific community.

Impact and Influence

As an educator and mentor, Dr. Shakya has guided over 70 master’s students, enhancing their research skills and helping them achieve their academic goals. His influence extends beyond teaching, as he has been involved in grant proposal writing, technical report authoring, and the procurement of sophisticated scientific equipment.

Dr. Shakya’s administrative roles have significantly impacted the research environment at Al-Ahliyya Amman University. He has promoted a culture of continuous quality management, encouraging faculty to publish in high-impact journals and facilitating research collaborations. His efforts have contributed to the university’s improved QS ranking and scientific reputation.

Legacy and Future Contributions

Dr. Shakya’s legacy lies in his unwavering commitment to advancing pharmaceutical sciences. His work in developing new analytical methods, synthesizing bioactive compounds, and mentoring future scientists has left an indelible mark on the field. As he continues his academic and research endeavors, Dr. Shakya remains dedicated to pushing the boundaries of pharmaceutical research and education.

🎓Publication