Khalid M Alkharfy| Herbal Medicine and Nutraceuticals | Best Researcher Award

Prof. Dr. Khalid M Alkharfy| Herbal Medicine and Nutraceuticals | Best Researcher Award

King Saud University, Saudi Arabia

Author Profile

Early Academic Pursuits 🎓

Prof. Dr. Khalid M. Alkharfy began his academic journey with an unwavering commitment to pharmaceutical sciences. Graduating with class honors from King Saud University in 1992 with a Bachelor of Pharmaceutical Sciences (B.Sc. Pharm), he established a solid foundation for his future contributions to the field. His academic excellence continued as he pursued a Doctor of Pharmacy (Pharm.D) at the University of Tennessee, USA, graduating in 1997 with class honors. During this period, Dr. Alkharfy honed his skills as a pharmacy intern at leading healthcare institutions in Memphis, Tennessee, including Veterans Affairs Medical Center, Regional Medical Center, and Baptist Memorial Hospital. This formative training emphasized his proficiency in adjusting and monitoring drug therapies, providing patient counseling, and collaborating with multidisciplinary medical teams.

Furthering his expertise, Dr. Alkharfy earned a Doctor of Philosophy (Ph.D.) in Pharmaceutical Sciences from the University of Pittsburgh in 2002. This significant achievement, recognized with distinction in clinical research, underscored his ability to conduct groundbreaking studies and set the stage for his impactful career in clinical and translational research.

Professional Endeavors and Leadership 🏢

Dr. Alkharfy’s professional journey is characterized by a series of prominent leadership roles, showcasing his scientific acumen and administrative capabilities. Starting as a Clinical Instructor at King Khalid University Hospital (1992-1994), he contributed to training pharmacy students while working with the nephrology medical team. His academic and research career blossomed further during his tenure as a Research Associate (1997-2002) at the University of Pittsburgh Medical Center, where he played a pivotal role in designing and conducting clinical trials, analyzing data, and disseminating findings through conferences and publications.

Returning to Saudi Arabia, Dr. Alkharfy joined King Saud University in 2002 as a Professor of Clinical and Translational Research in the Department of Clinical Pharmacy. In this capacity, he has led numerous initiatives, including the Translational and Drug Discovery Unit and the Biomarkers Research Program, focusing on metabolic disorders and diabetes. His leadership extended beyond academia as he served as Dean of the College of Pharmacy at Prince Sattam University (2013-2016) and as the Founding Dean of Almaarefa University’s College of Pharmacy (2011-2013).Additionally, Dr. Alkharfy took on national responsibilities as a Consultant for the Saudi Food and Drug Authority (SFDA), advising on regulatory frameworks and ensuring pharmaceutical standards. His global contributions include Visiting Scholar positions at renowned institutions such as Mayo Clinic (USA), the University of Hong Kong, and Charles University (Czech Republic).

Contributions and Research Focus 🔬

Dr. Alkharfy has made profound contributions to clinical and translational research, with a focus on metabolic disorders, diabetes, and drug discovery. As a leader in the Biomarkers Research Program, he has designed innovative studies to identify novel therapeutic targets and biomarkers for chronic diseases. His expertise has also extended to creating an ecosystem for R&D projects as Director of Riyadh Techno Valley, where he fostered collaborations between academia, industry, and government to advance Saudi Arabia’s science and technology infrastructure.Dr. Alkharfy has authored and co-authored over 260 scientific papers, abstracts, and publications, many of which have appeared in high-impact, peer-reviewed journals. His work demonstrates a commitment to advancing global health through robust research methodologies and interdisciplinary collaboration.

Accolades and Recognition 🏆

Over the years, Dr. Alkharfy’s accomplishments have garnered international recognition. As a Fulbright Scholar at Mayo Clinic (2019), he contributed to advanced clinical research in diabetes and pharmacotherapy. His expertise earned him invitations to prestigious visiting scholar positions at leading universities worldwide, including the University of Campinas (Brazil), International Islamic University Malaysia, and the University of Auckland (New Zealand).Dr. Alkharfy’s innovation is further evidenced by his four registered patents across Saudi Arabia, the USA, and Europe, reflecting his commitment to translating research into tangible solutions. His leadership as Dean and consultant roles have been instrumental in shaping pharmacy education and regulatory practices in Saudi Arabia.

Impact and Influence 🌍

Dr. Alkharfy’s work has had a lasting impact on both academia and public health policy. As a leader in clinical and translational research, his studies on diabetes and metabolic disorders have influenced treatment paradigms, while his patents have contributed to drug discovery and development. His mentorship of young scientists and pharmacy students has inspired a new generation of researchers and clinicians in Saudi Arabia and beyond.

Through his roles in national regulatory bodies and academic institutions, Dr. Alkharfy has played a critical part in strengthening the research infrastructure in Saudi Arabia, promoting innovation, and aligning the country’s scientific endeavors with international standards.

Legacy and Future Contributions 🌟

As Dr. Khalid M. Alkharfy continues his illustrious career, his legacy is firmly rooted in his dedication to research excellence, leadership, and education. His work has set a benchmark for integrating clinical and translational research with public health initiatives, fostering international collaborations, and nurturing talent in pharmaceutical sciences.

📖Notable Publications

Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents
  • Authors : Abdulaziz Al-Othman, Sara Al-Musharaf, Nasser M Al-Daghri, Soundararajan Krishnaswamy, Deqa S Yusuf, Khalid M Alkharfy, Yousef Al-Saleh, Omar S Al-Attas, Majed S Alokail, Osama Moharram, Shaun Sabico, George P Chrousos
  • Journal: BMC pediatrics
  • Year: 2012
Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency
  • Authors : Nasser M Al-Daghri, Omar S Al-Attas, Khalid M Alkharfy, Nasiruddin Khan, Abdul Khader Mohammed, Benjamin Vinodson, Mohammed Ghouse Ahmed Ansari, Amal Alenad, Majed S Alokail
  • Journal: Gene
  • Year: 2014
Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition
  • Authors : Mohammad Raish, Ajaz Ahmad, Mushtaq Ahmad Ansari, Khalid M Alkharfy, Fahad I Aljenoobi, Basit L Jan, Abdullah M Al-Mohizea, Altaf Khan, Naushad Ali
  • Journal: Biological Macromolecules
  • Year: 2018
Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects
  • Authors : Nasser M Al‐Daghri, Khalid M Alkharfy, Shakilur Rahman, Osama E Amer, Benjamin Vinodson, Shaun Sabico, Milan K Piya, Alison L Harte, Philip G McTernan, Majed S Alokail, George P Chrousos
  • Journal: European Journal of Clinical Investigation
  • Year: 2014
Application of Box–Behnken design for ultrasonic-assisted extraction of polysaccharides from Paeonia emodi
  • Authors : Ajaz Ahmad, Khalid M Alkharfy, Tanveer A Wani, Mohammad Raish Ansari; Muzaffar Iqbal; Ali N; Alkharfy KM et al.
  • Journal:biological macromolecules
  • Year: 2015

Dr. Barnabé Lucien NKONO YA NKONO|Phytopharmacology|Excellence in Pharmaceutical Innovation Award

Dr. Barnabé Lucien NKONO YA NKONO|Phytopharmacology|Excellence in Pharmaceutical Innovation Award

Dr. Barnabé Lucien NKONO YA NKONO at Abdul wali khan university mardan,Pakistan

PROFILE  

 

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Early Academic Pursuits 🎓

Dr. Barnabé Lucien Nkono Ya Nkono embarked on his academic journey with a strong passion for the life sciences. He demonstrated an exceptional aptitude for biological sciences early in his education, earning top honors in his undergraduate studies. Recognizing his potential, he pursued advanced studies in endocrinology and metabolic diseases, completing his Ph.D. with distinction. His dissertation laid the groundwork for his lifelong interest in diabetes, phytopharmacology, and toxicology, setting him apart as a rising star in his field.

Professional Endeavors and Academic Leadership 🌟

Dr. Nkono is a Senior Lecturer at the University of Yaoundé I, Higher Teacher Training College, Department of Biological Sciences. In this role, he has not only excelled as an educator but also as a mentor, inspiring a new generation of scientists. His dynamic teaching approach combines theoretical knowledge with practical applications, fostering a comprehensive learning environment for his students.
Beyond teaching, he has been actively involved in numerous research initiatives, spearheading projects focused on metabolic diseases and phytopharmacology. His contributions have cemented his reputation as a leading researcher in Cameroon and internationally.

Contributions and Research Focus 🔬

Dr. Nkono’s research spans a broad spectrum of critical topics, including:

  • Endocrinology and Metabolic Diseases: His work has advanced the understanding of diabetes and related metabolic disorders, with a focus on innovative therapeutic interventions.
  • Phytopharmacology: He has investigated the medicinal properties of various plant species, such as Alstonia boonei, Garcinia kola, and Cymbopogon citratus. His research emphasizes the potential of natural products in managing hyperglycemia, oxidative stress, and hyperlipidemia.
  • Toxicology: He has assessed the safety profiles of plant extracts, ensuring their suitability for therapeutic use.

Dr. Nkono’s studies have led to groundbreaking discoveries in the efficacy of traditional African medicinal plants. For instance, his work on Alstonia boonei demonstrated significant antihyperglycemic and antioxidant properties, while his exploration of Vernonia amygdalina highlighted its antiproliferative effects on osteosarcoma cells.

Accolades and Recognition 🏆

Dr. Nkono has received widespread acclaim for his contributions to science and medicine. His publications have been featured in prestigious journals, such as the International Journal of Diabetes Research and the Pan African Medical Journal. His peers and institutions alike have recognized him for his dedication to advancing knowledge in metabolic diseases and phytopharmacology.

Impact and Influence 🌍

Through his research, Dr. Nkono has contributed significantly to public health initiatives aimed at combating diabetes and metabolic disorders in Africa. His findings have informed policies and practices, bridging the gap between traditional medicine and modern healthcare. As a mentor, he has guided numerous graduate and postgraduate students, many of whom have gone on to make their own marks in the biological sciences.

Dr. Nkono’s influence extends beyond academia, impacting the wider community by promoting the use of safe and effective phytopharmaceuticals. His efforts have highlighted the value of indigenous knowledge systems in addressing global health challenges.

Legacy and Future Contributions 🚀

Dr. Nkono’s legacy lies in his dual commitment to rigorous scientific inquiry and the application of research for societal benefit. His work continues to inspire innovation in the treatment of metabolic diseases, particularly through the exploration of phytochemicals.
Looking ahead, Dr. Nkono is dedicated to furthering his research on the interplay between natural compounds and chronic diseases, with a focus on uncovering novel therapeutic agents. He also aims to expand his collaborative network, fostering international partnerships to amplify the global impact of his research.

Conclusion 🌱

Dr. Barnabé Lucien Nkono Ya Nkono is a pioneer in the fields of endocrinology, metabolic diseases, phytopharmacology, and toxicology. His academic achievements, research contributions, and dedication to teaching have made him an influential figure in his field. As he continues to push the boundaries of knowledge, his work promises to leave a lasting impact on science and humanity.

🎓Publication 

Acute and chronic anti-inflammatory effects of the aqueous extract of Acacia nilotica (L.) Del.(Fabaceae) pods

  • Authors   : SD Sokeng, J Koubé, F Dongmo, S Sonnhaffouo, BLNY Nkono, GS Taïwé, Y Cherrah, P Kamtchouing
  • Journal    :Academia Journal of Medicinal Plants
  • Year         :2013

Subchronic toxicity of aqueous extract of Alstonia boonei de wild.(apocynaceae) stem bark in normal rats

    • Authors   :Barnabé Lucien Nkono Ya Nkono, Selestin Dongmo Sokeng, Dzeufiet Djomeni Paul Désiré, Longo Frida, Pierre Kamtchouing
    • Journal    : International Journal of Pharmacology and Toxicology
    • Year         :2015

Antihyperglycemic effect of Vernonia amygdalina and in vitro evaluation of its antiproliferative activity on human osteosarcoma MG-63

  • Authors   :Barnabé Lucien Nkono Ya Nkono, Ablassé Rouamba, Ioana Alexandra Duceac, Liliana Verestiuc
  • Journal    : Pan African Medical Journal
  • Year         :2022

Antidiabetic and Antiradical Effects of Garcinia kola Seeds in Dexamethasone‑Induced Hyperglycemic Rats

  • Authors   :Barnabé Lucien Nkono Ya Nkono, Ablassé Rouamba, Mc Jesus Kinyok, Jean Guy Stéphane Omokolo, Balthazar Tchouanka Tcheudi, Benjamin Arnaud Tigui, Paul Désiré Dzeufiet Djomeni, Selestin Sokeng Dongmo, Pierre Kamtchouing
  • Journal     :International Journal of Applied and Basic Medical Research
  • Year         :2022

Hypoglycemic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Maize Silk on Dexamethasone-induced-hyperglycemic Rats

  • Authors   :Barnabé Lucien Nkono Ya Nkono, Rouamba Ablassé, Soumiatou Nzikoué, Léocadie Mbella Kédi, Placide Yannick Amougou Noa, Paul Désiré Djomeni Dzeufiet, Sélestin Dongmo Sokeng, Pierre Kamtchouing
  • Journal    : Journal of Cardio-diabetes and metabolic disorders
  • Year         :2022

Assist Prof Dr. Tewin Tencomnao| Herbal Medicine|Best Researcher Award

Assist Prof Dr. Tewin Tencomnao, Herbal Medicine,Best Researcher Award

Assist Prof Dr. Tewin Tencomnao, at Chulalongkorn University,Thailand

PROFIL

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🎓Early Academic Pursuits :

Asst. Prof. Dr. Tewin Tencomnao’s academic journey began with a strong foundation in medical technology. He earned his Bachelor of Science (B.S.) degree in Medical Technology with honors in 1994 from Chulalongkorn University, Bangkok, Thailand. This early achievement was a precursor to his dedication to academic excellence and set the stage for his future endeavors in biochemistry and molecular biophysics. Driven by a passion for scientific inquiry, Dr. Tencomnao pursued further education abroad, obtaining his Ph.D. in Biochemistry and Molecular Biophysics in 2001 from the prestigious Medical College of Virginia Campus of Virginia Commonwealth University in Richmond, Virginia, USA.

His pursuit of knowledge didn’t stop there. After earning his Ph.D., Dr. Tencomnao embarked on postdoctoral research training at the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA, from 2001 to 2002. This period of intensive research provided him with advanced skills and deepened his understanding of molecular biology and genetics, which would become central themes in his later work.

🧪Professional Endeavors :

Dr. Tewin Tencomnao’s professional career is marked by a series of prestigious appointments that reflect his expertise and leadership in the field of biochemistry and molecular biology. He currently holds several key positions at Chulalongkorn University, one of Thailand’s leading educational institutions. As the Head of the Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing, Dr. Tencomnao leads cutting-edge research initiatives aimed at discovering natural products with neuroprotective and anti-aging properties. This role underscores his commitment to addressing some of the most pressing health challenges of our time, including neurodegenerative diseases and the aging process.

Dr. Tencomnao also chairs the Bachelor’s Degree Program in Medical Technology at the Faculty of Allied Health Sciences. In this capacity, he oversees the curriculum and ensures that the program remains at the forefront of medical technology education. His leadership in this role has helped maintain the program’s reputation for excellence, producing graduates who are well-prepared to meet the demands of the healthcare industry.

🔬Contributions and Research Focus :

Dr. Tencomnao’s research interests are broad and multidisciplinary, encompassing drug discovery, natural products, molecular biology, biochemistry, and neuroscience. His work is particularly focused on understanding the mechanisms underlying neuropsychiatric diseases, anti-aging, and neuroprotection. Through his research, Dr. Tencomnao aims to uncover new therapeutic strategies that can improve the quality of life for individuals suffering from neurodegenerative diseases and age-related conditions.

🏆Accolades and Recognition :

Dr. Tencomnao’s contributions to science and education have not gone unnoticed. In 2021, he was awarded a Fulbright grant as a Thai Visiting Scholar to conduct research in the USA. This prestigious grant allowed him to further his research at the Department of Physiology, College of Medicine, University of Kentucky. The Fulbright award is a testament to Dr. Tencomnao’s international reputation as a leading researcher in his field.

In 2015, Dr. Tencomnao was honored with the DMSc Award from the Department of Medical Sciences, Ministry of Public Health, Thailand, for his outstanding research on the anti-neuroprotective effects and mechanisms of Rhinacanthus nasutus extracts. His innovative research was also recognized internationally when he received the Gold Award in the field of innovation from Universiti Malaysia Perlis, Malaysia, at the International Engineering Invention & Innovation Exhibition (i-ENVEX) for his work on an anti-aging cream with natural resveratrol from Perlis grapevine.

🌍Impact and Influence :

Dr. Tencomnao’s impact extends beyond his research contributions. As an educator, he has influenced countless students who have gone on to make their mark in various fields of science and healthcare. His work at Chulalongkorn University has helped shape the direction of research and education in Thailand, particularly in the areas of biochemistry, molecular biology, and natural products.

His research on neuroprotection and anti-aging has the potential to impact public health on a global scale. By identifying natural compounds that can protect against neurodegeneration, Dr. Tencomnao’s work could lead to the development of new treatments for some of the most challenging diseases of our time. His research also contributes to the growing body of knowledge on the health benefits of natural products, which is increasingly important as the world seeks sustainable and natural solutions to health challenges.

🌟Legacy and Future Contributions :

Asst. Prof. Dr. Tewin Tencomnao’s legacy is one of innovation, leadership, and a commitment to advancing science and education. His work in neuroprotection, anti-aging, and natural products has already made a significant impact, and his ongoing research promises to continue this trend. As he continues to lead the Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing, his future contributions will likely further our understanding of how natural products can be used to promote health and longevity.

🎓Publication 

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  • Authors   :Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar
  • Journal    :autophagy
  • Year         :2021

A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy

    • Authors :Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut, Tewin Tencomnao
    • Journal   :Nutrients
    • Year       : 2019

Amyloidosis in Alzheimer’s Disease: The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy

  • Authors  :Anchalee Prasansuklab, Tewin Tencomnao
  • Journal    :Evidence‐Based Complementary and Alternative Medicine
  • Year         :  2013

Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on NF-κB signaling biomarkers in HaCaT keratinocytes

  • Authors  :Chanachai Saelee, Visa Thongrakard, Tewin Tencomnao
  • Journal    :Molecules
  • Year         :  2011

Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach

  • Authors  :Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Sunita Nilkhet, Tewin Tencomnao, Alison T Ung, Siriporn Chuchawankul
  • Journal    :Journal of traditional and complementary medicine
  • Year         :  2021

Assist Prof Dr. Maryam Rangchian|Herbal Medicine| Best Researcher Award-1235

Assist Prof Dr. Maryam Rangchian ,Herbal Medicine,Best Researcher Award

Assist Prof Dr. Maryam Rangchian , at Pharmacy School of Hamadan University of Medical Sciences,Iraq

PROFILE

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Early Academic Pursuits 📚

Maryam Rangchian’s journey in the field of pharmacy began with a solid foundation in her early academic years. She excelled in her studies, securing the third national position in the Basic Science Exam in 2002. This early achievement was a testament to her dedication and intellectual prowess. Maryam pursued her Pharm.D. at Shahid Beheshti University of Medical Sciences in Tehran, where she continued to distinguish herself. She was recognized as the Excellent Student of Pharmacy School in 2008, a recognition that highlighted her commitment and exceptional performance in her studies. This period laid the groundwork for her future endeavors in the field of pharmacoeconomics and pharma management.

💼Professional Endeavors :

Maryam Rangchian’s professional journey is marked by significant contributions and leadership roles in academia and industry. As an Assistant Professor at the Pharmacy School of Hamadan University of Medical Sciences, she has been instrumental in shaping the future of pharmacy education. Her role as the Director of the Office of Industry and Society Relations further underscores her commitment to bridging the gap between academia and industry. Maryam’s expertise in pharmacoeconomics and pharma management is reflected in her consultancy work, where she has successfully led five industry projects, demonstrating her ability to apply academic knowledge to practical, real-world challenges.

🔬Contributions and Research Focus :

Maryam’s research focuses on critical areas such as pharmaceutical care, the market for pharmaceutical and personal care products, and the social responsibility of institutions and individuals in the pharmaceutical sector. She has completed or is currently engaged in 33 research projects, showcasing her prolific research activity. Her work has been widely recognized, with 23 publications in journals indexed by Scopus and other scientific databases. Maryam’s research is not just about numbers; it has a real impact on improving medication processes. The interventions she has suggested have been well-received by patients and have provided valuable insights for enhancing pharmaceutical practices.

🏆Accolades and Recognition :

Maryam Rangchian’s contributions to the field have not gone unnoticed. She has received several prestigious honors, including being named the Hamadan Exemplar Pharmacist in 2023. Her academic excellence was recognized early on, as she was awarded the title of Excellent Student in the Pharmacoeconomics and Pharma Management Department in 2015 at Shahid Beheshti University of Medical Sciences. Maryam also achieved first place in the comprehensive exam in the field of pharmacoeconomics and pharma management. These accolades reflect her dedication, hard work, and outstanding contributions to the field of pharmacy.

🌍Impact and Influence :

Maryam’s work has had a significant impact on both the academic community and the pharmaceutical industry. Her research findings have contributed to the development of better medication processes, benefiting patients and healthcare providers alike. As an invited reviewer for numerous prestigious journals, including BMC Health Services Research, BMC Medical Education, and BMJ Open, she has played a crucial role in shaping the quality of research in her field. Her active involvement in professional associations, such as the Iranian Association of Pharma Management and Economics and the International Society of Pharmacoeconomics and Outcome Research, further amplifies her influence and commitment to advancing her field.

🌟Legacy and Future Contributions :

Looking ahead, Maryam Rangchian is poised to continue her impactful work in pharmacoeconomics and pharma management. Her legacy is one of academic excellence, professional dedication, and meaningful contributions to healthcare. She is committed to furthering research that addresses the evolving challenges in the pharmaceutical industry, focusing on areas such as pharmaceutical care, market dynamics, and social responsibility. Maryam’s future contributions will undoubtedly build on her strong foundation, driving innovation and improving healthcare outcomes.

🎓Publication 

Performance model of community pharmacies in low-middle income countries: A societal perspective

  • Authors   :Ranghchian, M.; Sehat, S.; Akhgari, M.; Mehralian, G.r
  • Journal    :Retailing and Consumer Services
  • Year         : 2018

Underlying factors influencing community pharmacies business in low- to medium-developed markets: A societal perspective

    • Authors :Rangchian, M.; Mehralian, G.; Salamzadeh, J.; Vatanpour, H
    • Journal   :Pharmaceutical Health Services Research
    • Year       : 2016

Pharmaceutical care in a community-based practice setting in Iran: Current status and future challenges

  • Authors  :Mehralian, G.; Rangchian, M.; Afsharmanesh, G.; Seifi, N.
  • Journal    :Pharmaceutical Health Services Research
  • Year         :  2015

Client priorities and satisfaction with community pharmacies: The situation in Tehran

  • Authors  :Mehralian, G.; Rangchian, M.; Rasekh, H.R.
  • Journal   :Clinical Pharmacy
  • Year        :   2014

 

Investigation on barriers to pharmaceutical care in community pharmacies: a structural equation model

  • Authors  :Mehralian, G.; Rangchian, M.; Javadi, A.; Peiravian, F.
  • Journal   :Clinical Pharmacy
  • Year        :   2014