Hui Xiao | Drug Discovery and Development | Pharmaceutical Innovation Achievement Award

Hui Xiao | Drug Discovery and Development | Pharmaceutical Innovation Achievement Award

Dr Hui Xiao,regeneron,United States

Dr. Hui Xiao 🧪🔬 is a distinguished scientist specializing in biochemistry, structural biology, and mass spectrometry. With a strong focus on microtubule dynamics, protein interactions, and drug mechanisms, he has made significant contributions to understanding cellular processes. As a co-first author and lead researcher, his work has been published in esteemed journals like J. Mol. Biol., Biochemistry, and J. Biol. Chem.. His expertise spans hydrogen-deuterium exchange, proteomics, and molecular stabilization studies. Dr. Xiao’s research has advanced drug discovery, particularly in cancer therapeutics and protein biochemistry. 📚🔍 His innovative approaches continue to impact biomedical sciences globally. 🌍✨

Publication Profile

Scopus

Education

Dr. Hui Xiao 🎓 holds a Ph.D. in Analytical Chemistry from the University of Massachusetts, Amherst (2005) and a degree in Applied Chemistry from Peking University, China (1992). Currently serving as an Associate Director at Regeneron Pharmaceuticals 🏢, he specializes in protein characterization using mass spectrometry. With over a decade at Regeneron, he has progressed through roles as a Senior Staff Scientist and Staff Scientist. Previously, he held academic positions at Albert Einstein College of Medicine 🧬, advancing from Instructor to Research Associate Professor. His expertise spans analytical chemistry, protein analysis, and therapeutic protein research, making significant contributions to biomedical science. 🔬

Professional Impact

Dr. Hui Xiao 🎓 is a distinguished scientist with over 20 years of experience in academia and the biotechnology industry. Currently, he serves as an Associate Director of Analytical Chemistry at Regeneron Pharmaceuticals 🏢, a leading biotech company. His expertise lies in mass spectrometry applications for protein characterization 🔬, contributing to advancements in therapeutic development. Before joining Regeneron, Dr. Xiao held esteemed faculty positions at Albert Einstein College of Medicine 🧬, progressing from Instructor to Research Associate Professor. His extensive research and leadership have played a crucial role in bridging analytical chemistry with biopharmaceutical innovation, impacting drug discovery and development. 🚀

Scientific Contributions

Dr. Hui Xiao 🎓 is a leading expert in protein-ligand interactions, structural proteomics, and therapeutic protein analysis 🔬. His pioneering work includes the application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) for epitope mapping 🧩 and microtubule stabilization research. With a deep focus on drug characterization and regulatory sciences, his contributions have significantly advanced biopharmaceutical development 💊. His expertise in mass spectrometry-driven protein analysis has helped enhance the understanding of molecular mechanisms, improving therapeutic strategies. Through innovation and research, Dr. Xiao continues to play a vital role in shaping the future of biopharmaceutical science and drug discovery. 🚀

Potential Considerations

Dr. Hui Xiao 🎓 is a renowned expert in analytical and protein chemistry, with groundbreaking work in epitope mapping and protein characterization 🔬. While his contributions significantly impact drug development, the Pharmaceutical Innovation Achievement Award 🏆 may prioritize direct advancements in drug discovery and novel pharmaceutical interventions 💊. His research has important regulatory and therapeutic implications, but highlighting specific drug innovations or regulatory breakthroughs he has led would further strengthen his case. By showcasing his role in pioneering pharmaceutical advancements, Dr. Xiao’s influence in shaping modern biopharmaceutical science can be fully recognized and appreciated. 🚀

Research Focus

Dr. Hui Xiao’s research primarily focuses on analytical chemistry 🧪, particularly in the quantitative analysis of biomolecules 🧬 using advanced mass spectrometry techniques ⚖️. His work involves CRISPR sgRNA modification analysis 🧬🔬 and the development of LC-MS-based assays for biological therapeutics 💊. He specializes in phosphorothioate isomer detection 🔄 and liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) 📊 for precise biomolecular quantification. His contributions are crucial in drug discovery 🏥, gene editing 🧬, and biopharmaceutical development 💉. His expertise bridges biotechnology 🔬 and analytical methodologies 📈, advancing innovations in therapeutic monitoring and molecular diagnostics 🏥.

Publication Top Notes

Quantitative Analysis of Phosphorothioate Isomers in CRISPR sgRNA at Single-Residue Resolution Using Endonuclease Digestion Coupled with Liquid Chromatography Cyclic Ion Mobility Mass Spectrometry (LC/cIMS)

Generic Enrichment Method for Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Biological Therapeutics in Serum

Dr.Alice Bejjan| Pharmaceutical Analysis| Women Researcher Award

Dr.Alice Bejjan,Pharmaceutical Analysis ,Women Researcher Award

Dr.Alice Bejjan, at ational Council for Scientific Research of Lebanon-Lebanese Atomic Energy Commission, Lebanon

 Profiles

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Orcid

🎓Early Academic Pursuits :

Alice Bejjani’s journey into the world of physics began with a solid academic foundation. She pursued her undergraduate studies at the Lebanese University, Department of Physics and Electronics in Fanar, Lebanon, where she earned her Maitrise in Physics with high distinction in 2003. Her passion for materials science and electronic components led her to continue her studies at the Lebanese University, Faculty of Sciences. There, she obtained a Master of Advanced Studies (DEA) in 2004, once again graduating with high distinction. Alice’s academic pursuits culminated in a Ph.D. in Physics from the Claude Bernard University of Lyon, Institute of Nuclear Physics, France, in 2009, where she achieved the highest honors.

🏢Professional Endeavors :

Alice’s professional career is marked by her extensive contributions to the Lebanese Atomic Energy Commission-National Council for Scientific Research (LAEC-NCSR). She began her journey as a part-time research assistant at the Accelerator Laboratory of LAEC-NCSR in 2004-2005. Following her Ph.D., she returned to LAEC-NCSR as a part-time researcher, equivalent to a post-doctoral position, from 2010 to 2014. During this time, she played a pivotal role in establishing the first research laboratory in the MENA region for surface, chemical, and structural analysis of solid materials using the Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS) technique.

In 2014, Alice was appointed as a full-time researcher at LAEC-NCSR, a position she held until 2019. Her research interests include exploring novel applications, developing innovative protocols, and combining ion beam technology with optical spectroscopic and chromatography methods to examine materials pertinent to health, environmental studies, and forensic sciences. Since 2019, she has been serving as a senior researcher, furthering her contributions to the field.

🔬Contributions and Research Focus :

Alice’s research has had a profound impact on the fields of health, environmental studies, and forensic sciences. As the coordinator of the Forensic Research Program at LAEC-NCSR since 2016, she has fostered synergy among her fellow researchers to achieve program objectives. She has designed and implemented Memorandums of Understanding (MOUs) with partners, driving impactful advancements in forensic research.

As the principal investigator of the TOF-SIMS laboratory, Alice oversees a team of researchers, research assistants, and master’s/Ph.D. students. She has established and enforced standard operating protocols to ensure compliance with safety and regulatory guidelines, maintained the laboratory’s cutting-edge status through equipment procurement and technology advancements, and implemented preventive maintenance plans to ensure optimal functionality and efficiency. Her efforts have also included fostering collaborations with local and international universities and research centers.

 🏆Accolades and Recognition :

Alice’s dedication and contributions to science have been recognized through various national and international grants. Notable among these are:

  1. TC-IAEA Grant (2022-2025): €405,000 for strengthening forensic needs in material investigation.
  2. NCSR National Grant (2018-2019): $19,000 for multi-dimensional analysis of new functional polymers.
  3. NCR Italy-NCSR Mobility Grant (2017-2019): €8,000 for safeguarding saffron authenticity using innovative mass spectrometry.
  4. TC-IAEA Grant (2015-2018): €350,000 for enhancing forensic science capabilities.
  5. TC-IAEA Grant (2012-2014): €350,000 for upgrading surface, elemental, and structural analysis capabilities.
  6. TC-IAEA Grant (2010-2012): €522,000 for enhancing the LAEC’s analytical capabilities.

🌟Impact and Influence :

Alice’s work has had a significant impact on the scientific community and beyond. Her research has contributed to advancements in forensic science, health, and environmental studies. By developing innovative protocols and combining ion beam technology with other analytical methods, she has opened new avenues for material analysis. Her leadership in establishing and maintaining the TOF-SIMS laboratory has provided valuable resources for researchers in the MENA region and internationally.

🌍Legacy and Future Contributions :

Alice Bejjani’s legacy is one of dedication, innovation, and collaboration. Her contributions to the scientific community, particularly in the fields of forensic science and material analysis, have set a high standard for future researchers. As she continues her work at LAEC-NCSR, she is poised to make further advancements in her field, fostering interdisciplinary collaboration and driving impactful research. Her commitment to mentoring the next generation of scientists ensures that her influence will continue to be felt for years to come. Alice’s journey is a testament to the power of perseverance, passion, and the pursuit of excellence in science.

🎓Publication 

Fe0-based trimetallic systems for the removal of aqueous diclofenac: Mechanism and kinetics

  • Authors   :Antoine Ghauch, Hala Abou Assi, Habib Baydoun, Al Muthanna Tuqan, Alice Bejjani
  • Journal    :Chemical Engineering Journal
  • Year         : 2011

Iron-based metal organic framework MIL-88-A for the degradation of naproxen in water through persulfate activation

    • Authors : Rime El Asmar, Abbas Baalbaki, Zahraa Abou Khalil, Sahar Naim, Alice Bejjani, Antoine Ghauch
    • Journal   :Chemical Engineering Journal
    • Year       : 2011
Toward cell selective surfaces: cell adhesion and proliferation on breath figures with antifouling surface chemistry
  • Authors  : Enrique Martínez-Campos, Tamara Elzein, Alice Bejjani, Maria Jesús García-Granda, Ana Santos-Coquillat, Viviana Ramos, Alexandra Muñoz-Bonilla, Juan Rodríguez-Hernández
  • Journal    :ACS Applied Materials & Interfaces
  • Year         :  2016
Hydrophobization of chitosan films by surface grafting with fluorinated polymer brushes
  • Authors  : Bénédicte Lepoittevin, Tamara Elzein, Diana Dragoe, Alice Bejjani, Frédéric Lemée, Jocelyne Levillain, Philippe Bazin, Philippe Roger, Isabelle Dez
  • Journal   :Carbohydrate polymers
  • Year        :   2019

Surface initiated supplemental activator and reducing agent atom transfer radical polymerization (SI-SARA-ATRP) of 4-vinylpyridine on poly (ethylene terephthalate)

  • Authors  : Mohamad Maaz, Tamara Elzein, Alice Bejjani, Nadine Barroca-Aubry, Bénédicte Lepoittevin, Diana Dragoe, Sandra Mazerat, Bilal Nsouli, Philippe Roger
  • Journal   :Journal of colloid and interface science
  • Year        : 2017