Sandip Kaledhonkar | Drug Discovery and Development | Research Excellence Award

Published on by Top Pharmaceutical

Assoc. Prof. Dr. Sandip Kaledhonkar | Drug Discovery and Development | Research Excellence Award

Indian Institute of Technology Bombay | India

Assoc. Prof. Dr. Sandip Kaledhonkar is a distinguished scientist whose work spans biophysics, structural biology, cryo-electron microscopy, and molecular microbiology. He currently serves in the Department of Biosciences and Bioengineering at the Indian Institute of Technology Bombay, where he contributes to cutting-edge research, innovative teaching, and academic mentorship. Prior to his current role, he progressed through key academic and research appointments, including his tenure as Assistant Professor at IIT Bombay, a scientific role at the Haffkine Institute for Training, Research and Testing in Mumbai, and an impactful post-doctoral fellowship at Columbia University Medical Center in New York. These experiences collectively shaped his expertise in structural dynamics, cryo-EM methodologies, and molecular interactions critical to understanding biological systems.Dr. Kaledhonkar earned his Ph.D. in Physics from Oklahoma State University, where he conducted foundational work on the Structural Dynamics of Photoactive Yellow Protein under the guidance of Dr. Aihua Xie. He further strengthened his academic foundation with an M.Sc. and B.Sc. in Physics from the University of Pune. His teaching portfolio reflects his multidisciplinary strengths, covering subjects such as Mathematics for Biologists, Experimental Techniques in Biomedical Engineering, Computational Biology, cryo-Electron Microscopy, and core undergraduate biology.His research contributions have significantly advanced the field, with notable publications including titles such as In Silico Identification of Potential Inhibitors of Mycobacterium tuberculosis DNA Gyrase from Phytoconstituents of Indian Medicinal Plants, Cryo-EM Reconstruction of the phiK601 Jumbo Phage Head, VCP/p97, a Host AAA-ATPase Exhibits Bacteriolytic Activity for Clearance of Microbial Infection, Conformational Flexibility Associated with Remote Residues Regulate the Kinetic Properties of Glutamate Dehydrogenase, and Application of Bio-Layer Interferometry for the Analysis of Ribosome-Protein Interactions. Other influential works include Physiochemical Characterization of a Potential Klebsiella Phage MKP-1, Not All Photoactive Yellow Proteins Are Built Alike, and landmark cryo-EM studies such as Late Steps in Bacterial Translation Initiation Visualized Using Time-Resolved Cryo-EM and Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryo-Electron Microscopy. His scholarly record also features important methodological contributions, including Single Particle Cryo-Electron Microscopy and A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM.Dr. Kaledhonkar’s excellence has been recognized through numerous honors, including prestigious microscopy, teaching, and research awards, as well as membership in India’s premier scientific academies. His work continues to influence modern bioscience research, inspiring new advancements in structural biology and biomedical innovation.

Profile: Google Scholar

Featured Publications

Feng, X., Fu, Z., Kaledhonkar, S., Jia, Y., Shah, B., Jin, A., Liu, Z., Sun, M., & Chen, B. (2017). A fast and effective microfluidic spraying‑plunging method for high‑resolution single‑particle cryo‑EM. Structure, 25(4), 663‑670.e3.

Chen, B., Kaledhonkar, S., Sun, M., Shen, B., Lu, Z., Barnard, D., & Lu, T. M. (2015). Structural dynamics of ribosome subunit association studied by mixing‑spraying time‑resolved cryogenic electron microscopy. Structure, 23(6), 1097‑1105.

Fu, Z., Indrisiunaite, G., Kaledhonkar, S., Shah, B., Sun, M., & Chen, B. (2019). The structural basis for release factor activation during translation termination revealed by time‑resolved cryogenic electron microscopy. Biophysical Journal, 116(3), 574a‑575a.

Fu, Z., Kaledhonkar, S., Borg, A., Sun, M., Chen, B., Grassucci, R. A., & Ehrenberg, M. (2016). Key intermediates in ribosome recycling visualized by time‑resolved cryoelectron microscopy. Structure, 24(12), 2092‑2101.

Horst, M. A., Stalcup, T. P., Kaledhonkar, S., Kumauchi, M., Hara, M., & Xie, A. (2009). Locked chromophore analogs reveal that photoactive yellow protein regulates biofilm formation in the deep‑sea bacterium Idiomarina loihiensis. Journal of the American Chemical Society, 131(47), 17443‑17451.

Kaledhonkar, S., Fu, Z., White, H., & Frank, J. (2018). Time‑resolved cryo‑electron microscopy using a microfluidic chip. In Protein Complex Assembly: Methods and Protocols (pp. 59‑71).

Kaledhonkar, S., Hara, M., Stalcup, T. P., Xie, A., & Hoff, W. D. (2013). Strong ionic hydrogen bonding causes a spectral isotope effect in photoactive yellow protein. Biophysical Journal, 105(11), 2577‑2585.

Palaniyandi Velusamy | Drug Discovery and Development |

Published on by Top Pharmaceutical

Prof. Dr. Palaniyandi Velusamy | Drug Discovery and Development | Research Excellence Award

Sree Balaji Medical College and Hospital  | India

Prof. Dr. Palaniyandi Velusamy is a distinguished researcher, academic leader, and biotechnology expert recognized for his extensive contributions to microbiology, nanobiotechnology, biosciences, and antibacterial drug research. He began his academic journey with foundational studies in botany and biochemistry before completing his doctoral research at the University of Madras, where he specialized in antibacterial agents and developed research competencies that shaped his future scientific pursuits. Following his Ph.D., he undertook multiple prestigious post-doctoral fellowships across internationally reputed institutions in Taiwan and South Korea, including Academia Sinica, Korea University, and Chonnam National University, where he contributed to advanced research in nanotechnology, microbial applications, and bioengineering. He later served as a Visiting Professor at Kyung Hee University in South Korea, strengthening his global academic footprint. In India, he built a progressive academic career at SRM University, where he contributed as Assistant Professor, Associate Professor, and later took on key departmental responsibilities including Deputy Controller of Examinations, Research Coordinator, Department Treasurer, Class In-Charge for B.Tech and M.Tech programs, Counsellor, and Course Coordinator for key subjects such as Microbial Technology, Microbiology, Enzyme Technology, Bionanotechnology, Green Chemistry, Pharmaceutical Engineering, and Phytochemistry. His academic leadership expanded further when he joined Sree Balaji Medical College and Hospital, Chennai, where he served as Professor and currently holds the role of Joint Director at the Innovation & Incubation Centre, guiding institutional innovation, research development, and technology incubation.Prof. Velusamy’s contributions to scientific publishing are extensive; he serves as Editor for Scientific Reports (Nature Publishing Group), Associate Editor for Frontiers in Bioengineering and Biotechnology, Editor for the Global Journal of Pathology and Microbiology, Guest Editor for Biosensors, and Editorial Board Member for the Austin Journal of Nanomedicine & Nanotechnology. He is also an invited reviewer for globally recognized journals including Colloids and Surfaces B, Spectrochimica Acta Part A, Heliyon, and the International Journal of Biological Macromolecules.

Profile: Orcid

Featured Publications

Krishnan, N., Singh, P. K., Sakthivelu, M., Velusamy, P., Gopinath, S. C. B., & Raman, P. (2024). Influence of thermal treatment on extraction and characteristics of phytochemicals from rhizome of _Acorus calamus L_. Biomass Conversion and Biorefinery. doi:10.1007/s13399-022-03415-y

Velusamy, P., Jeyanthi, V., Pachaiappan, R., Anbu, P., & Gopinath, S. C. B. (2024). Secretion of 2,4‑di‑tert‑butylphenol by a new _Pseudomonas strain SBMCH11: A tert‑butyl substituted phenolic compound displayed antibacterial efficacy_. Results in Chemistry, 6, 101593. doi:10.1016/j.rechem.2024.101593

Velusamy, P., Su, C.-H., Ramasamy, P., Arun, V., Rajnish, N., Raman, P., Baskaralingam, V., Kumar, S. M. S., & Gopinath, S. C. B. (2023). Volatile Organic Compounds as Potential Biomarkers for Noninvasive Disease Detection by Nanosensors: A Comprehensive Review. Critical Reviews in Analytical Chemistry, 53(4), 1‑30. doi:10.1080/10408347.2022.2043145

Soundararajan, P., Parthasarathy, S., Sakthivelu, M., Karuppiah, K. M., Velusamy, P., Gopinath, S. C. B., & Raman, P. (2023). Effects of Consuming Repeatedly Heated Edible Oils on Cardiovascular Diseases: A Narrative Review. Current Medicinal Chemistry, 30(30), 1‑18. doi:10.2174/0109298673250752230921090452

Ramesh, V., Kulkarni, S. A., Velusamy, P., Devadasan, V., Devaraju, P., Rajnish, K. N., Madhavan, T., Anbu, P., Ramasamy, P., & Sundarraj, R. (2022). Current Update of Phytotherapeutic Agents in the Treatment of COVID‑19: <i>In‑Silico</i> Based Virtual Screening Approach for the Development of Antiviral Drug. Frontiers in Bioscience‑Landmark, 27(4), 123. doi:10.31083/J.FBL2704123

Parthasarathy, S., Soundararajan, P., Krishnan, N., Karuppiah, K. M., Devadasan, V., Prabhu, D., Rajamanikandan, S., Velusamy, P., Gopinath, S. C. B., & Raman, P. (2022). Detection of adulterants from common edible oils by GC‑MS. Biomass Conversion and Biorefinery, 12(5), 1‑12. doi:10.1007/S13399-022-02913-3

Zaneta Nikolovska-Coleska | Drug Discovery and Development | Best Researcher Award

Published on by Top Pharmaceutical

Prof. Dr. Zaneta Nikolovska-Coleska | Drug Discovery and Development | Best Researcher Award

University of Michigan Medical School Department of Pathology | United States

Prof. Dr. Zaneta Nikolovska-Coleska is an accomplished pharmaceutical chemist and molecular pharmacologist recognized for her groundbreaking work in the design, synthesis, and development of molecularly targeted small molecules for cancer treatment. She earned her foundational and advanced degrees in pharmaceutical chemistry from the Faculty of Pharmacy at the University Ss. Cyril and Methodius in Skopje, where she also began her academic career as a young assistant and later advanced through multiple teaching and research positions. Her dedication to chemical sciences and biomedical innovation led her to the University of Michigan, Ann Arbor, where she currently serves as a Professor in the Department of Pathology and Associate Dean for Graduate and Postdoctoral Studies.Dr. Nikolovska-Coleska’s research is centered on the discovery of small molecule inhibitors that target protein–protein interactions involved in apoptosis, oncogenic signaling pathways, and epigenetic regulation. Her laboratory investigates mechanisms such as Mcl-1–Bim/Noxa, Bfl-1–Bim/Noxa, EZH2–p38 MAP kinase interactions, and histone methyltransferase activities, contributing to the identification of novel therapeutic targets for various malignancies. Through her integrative approach, combining chemical biology, medicinal chemistry, and translational oncology, she has developed promising compounds for the modulation of signaling pathways implicated in cancer progression and resistance.Her clinical and translational research extends into precision medicine, where she applies functional assays to predict anti-cancer drug responses, aiming to enhance individualized therapeutic strategies. As a clinician-research scholar and educator, she has mentored numerous postdoctoral fellows, clinical trainees, and graduate students, guiding them in developing innovative research methodologies and critical scientific reasoning.Throughout her illustrious career, Dr. Nikolovska-Coleska has played pivotal roles in multiple large-scale research initiatives, serving as Principal Investigator, Co-Investigator, and Mentor on numerous national and international grants focused on cancer biology, aging, and drug discovery. Her collaborations with global scientific institutions and pharmaceutical organizations have contributed to the advancement of targeted therapies, including the development of inhibitors against oncogenic proteins such as DOT1L, Mcl-1, EZH2, and PAPP-A.In addition to her research excellence, Dr. Nikolovska-Coleska has made outstanding contributions to academic leadership. As Director of the Molecular and Cellular Pathology Graduate Program and Associate Director of Academic Programs in Biomedical Sciences, she has overseen curriculum development, student recruitment, academic policy, and interdisciplinary research training. Her vision continues to shape the next generation of biomedical scientists, emphasizing the integration of molecular insights with clinical applications.Through her scholarly achievements, mentorship, and leadership, Prof. Dr. Zaneta Nikolovska-Coleska stands as a leading figure in pharmaceutical chemistry and translational oncology, dedicated to advancing science that bridges molecular discovery with therapeutic innovation.

Profile: Google Scholar

Featured Publications

Ding, K., Lu, Y., Nikolovska-Coleska, Z., Wang, G., Qiu, S., Shangary, S., Gao, W., et al. (2006). Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2−p53 interaction. Journal of Medicinal Chemistry, 49(12), 3432–3435.

Shangary, S., Qin, D., McEachern, D., Liu, M., Miller, R. S., Qiu, S., et al. (2008). Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proceedings of the National Academy of Sciences, 105(10), 3933–3938.

Ding, K., Lu, Y., Nikolovska-Coleska, Z., Qiu, S., Ding, Y., Gao, W., Stuckey, J., et al. (2005). Structure-based design of potent non-peptide MDM2 inhibitors. Journal of the American Chemical Society, 127(29), 10130–10131.

Nikolovska-Coleska, Z., Wang, R., Fang, X., Pan, H., Tomita, Y., Li, P., Roller, P. P., et al. (2004). Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. Analytical Biochemistry, 332(2), 261–273.

Nikolovska-Coleska, Z., Xu, L., Hu, Z., Tomita, Y., Li, P., Roller, P. P., Wang, R., et al. (2004). Discovery of embelin as a cell-permeable, small-molecular-weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine. Journal of Medicinal Chemistry, 47(10), 2430–2440.

Bagherian, M., Sabeti, E., Wang, K., Sartor, M. A., Nikolovska-Coleska, Z., et al. (2021). Machine learning approaches and databases for prediction of drug–target interaction: A survey paper. Briefings in Bioinformatics, 22(1), 247–269.

Wang, G., Nikolovska-Coleska, Z., Yang, C. Y., Wang, R., Tang, G., Guo, J., et al. (2006). Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. Journal of Medicinal Chemistry, 49(21), 6139–6142.