Ketan Ruparelia | Cancer Research | Research Excellence Award

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Research Excellence Award

Ketan Ruparelia — De Montfort University, United Kingdom

Ketan Ruparelia
Affiliation De Montfort University
Country United Kingdom
Scopus ID 6506888701
Documents 39
Citations 1,939
h-index 20
Subject Area Cancer Research
Event International Top Pharmaceutical Awards
ORCID 0000-0002-4091-2878

Ketan Ruparelia is a researcher affiliated with De Montfort University in Leicester, United Kingdom. His documented research works include studies spanning pharmaceutical and cancer-related research, including drug-delivery systems, anticancer compounds, phytochemical analysis, and medicinal chemistry. The available research record provides evidence of publications involving chemotherapy-related nanocarriers, synthetic resveratrol analogues, plant secondary metabolism, and flavone-based enzyme inhibition. These works provide a scholarly basis for considering his profile within pharmaceutical research and cancer-focused scientific activity. [1]

Abstract

Ketan Ruparelia’s documented research profile is associated with pharmaceutical and biomedical research, with particular relevance to cancer research, drug delivery, phytochemical investigation, and anticancer compound development. The available ORCID record lists five research works and identifies De Montfort University as his employment affiliation. [1]

Keywords

Ketan Ruparelia, pharmaceutical research, cancer research, drug delivery, nanomedicine, siRNA delivery, multidrug-resistant cancer, chemotherapy, mesoporous silica nanoparticles, anticancer compounds, resveratrol analogues, medicinal chemistry, phytochemical analysis, plant secondary metabolism, flavones, tyrosinase inhibitors, pharmaceutical biotechnology, International Top Pharmaceutical Awards.

Introduction

Pharmaceutical research increasingly combines medicinal chemistry, drug-delivery engineering, molecular biology, and natural-product investigation to address complex therapeutic challenges. Ruparelia’s documented works intersect several of these areas, particularly through research involving anticancer compounds and pharmaceutical delivery technologies. [1][3]

Research Profile

The ORCID record identifies Ketan Ruparelia and associates the profile with De Montfort University in Leicester, Leicestershire, United Kingdom. The employment entry specifies the position of Senior Technician in Health & Life Sciences, while the record also lists five works with Crossref-linked publication information. The supplied bibliometric profile reports 39 documents, 1,939 citations, and an h-index of 20, with Cancer Research identified as the principal subject area. [1]

Research Contributions

A central contribution documented in the available record concerns pharmaceutical nanotechnology and targeted nucleic-acid delivery. The 2025 European Journal of Pharmaceutics and Biopharmaceutics article examines electrosprayed core-shell polyethyleneimine and phospholipid-coated mesoporous silica nanoparticles for co-delivery of KAZ3 and MDR-1 siRNA. [1]

Publications

Ketan Ruparelia’s publications span pharmaceutical nanotechnology, cancer research, medicinal chemistry, and phytochemical analysis. His 2025 article on electrosprayed core-shell nanoparticles investigated KAZ3 and MDR-1 siRNA co-delivery for chemotherapy in multidrug-resistant colon cancer. [1] His other works examine synthetic resveratrol analogues, indanone-based chalcone analogues, plant secondary metabolism, and flavone tyrosinase inhibition. [2]

Research Impact

The reported bibliometric profile indicates 39 documents, 1,939 citations, and an h-index of 20. These figures provide quantitative indicators of scholarly visibility within the supplied profile, while the underlying publication record demonstrates activity across pharmaceutical delivery, cancer research, medicinal chemistry, and phytochemical investigation. In particular, nanoparticle-mediated siRNA delivery connects pharmaceutical formulation with cancer biology, whereas resveratrol analogue research links synthetic chemistry with anticancer investigation. [1][3]

Award Suitability

The documented research profile is relevant to a Research Excellence Award within a pharmaceutical research context because it encompasses multiple areas directly connected with drug development and cancer-oriented pharmaceutical science. The evidence includes peer-reviewed journal articles, DOI-indexed works, and research involving drug-delivery systems and anticancer compounds. [1][3]

Conclusion

Ketan Ruparelia’s documented research profile reflects interdisciplinary activity relevant to pharmaceutical and cancer research. His recorded works encompass nanocarrier-based siRNA delivery, anticancer resveratrol analogues, synthetic chemistry, phytochemical analysis, and enzyme-inhibitor research. The combination of these research areas provides a substantive scholarly basis for recognition under a pharmaceutical research excellence category.[1][3]

References

  1. Sayed, E., Ruparelia, K., Zafar, S., Faheem, A., Fatouros, D., Arshad, M. S., Singh, N., & Ahmad, Z. (2025). Novel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer. European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/j.ejpb.2025.114838
  2. Pal, P., Ruparelia, K. C., Arroo, R. R. J., & Brucoli, F. C. (2025). A Green Chemistry Approach for the Synthesis of Indanones as Fixed Ring Chalcone Analogues. Preprints. https://www.preprints.org/manuscript/202504.1089
  3. Ruparelia, K. C., Zeka, K., Beresford, K. J. M., Wilsher, N. E., Potter, G. A., Androutsopoulos, V. P., Brucoli, F., & Arroo, R. R. J. (2024). CYP1-Activation and Anticancer Properties of Synthetic Methoxylated Resveratrol Analogues. Molecules, 29(2). https://doi.org/10.3390/molecules29020423
  4. Arroo, R. R. J., Bhambra, A. S., Hano, C., Renda, G., Ruparelia, K. C., & Wang, M. F. (2021). Analysis of plant secondary metabolism using stable isotope-labelled precursors. Phytochemical Analysis. https://doi.org/10.1002/pca.2955
  5. Arroo, R. R. J., Sari, S., Barut, B., Özel, A., Ruparelia, K. C., & Şöhretoğlu, D. (2020). Flavones as tyrosinase inhibitors: kinetic studies in vitro and in silico. Phytochemical Analysis. https://doi.org/10.1002/pca.2897

Ihn Han | Oncology Pharmaceuticals | Best Researcher Award

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Prof. Dr. Ihn Han | Oncology Pharmaceuticals | Best Researcher Award

Deputy director of PBRC, at Kwangwoon University, South Korea.

Dr. Ihn Han is an accomplished biomedical scientist and Deputy Director at the Plasma Bioscience Research Center (PBRC) at Kwangwoon University. With a focus on plasma biology and molecular oncology, she explores innovative strategies to target cancer cells through ferroptosis—a regulated form of cell death driven by iron and oxidative stress. Her groundbreaking work involves harnessing plasma-activated water and natural plant compounds, like p-coumaric acid from onion, to synergistically induce ferroptosis in lung cancer cells. In addition to her work in oncology, Dr. Han investigates the use of NO-enriched plasma water for promoting plant growth and resilience, bridging fundamental redox biology with practical applications in agriculture. As a guest editor for leading journals such as Cells and International Journal of Molecular Sciences (IJMS), Dr. Han actively shapes the scientific discourse. Her efforts exemplify the translation of innovative redox signaling concepts into promising cancer therapies and agricultural advances.

Professional Profile

Scopus

ORCID

Google Scholar

🎓 Education 

Dr. Ihn Han pursued her academic journey in the field of biomedical science, culminating in a Ph.D. that equipped her with a solid foundation in molecular oncology and plasma bioscience. Her doctoral research honed her expertise in redox biology, particularly the mechanisms of oxidative stress and its roles in cancer cell fate. Throughout her academic path, Dr. Han has cultivated a deep understanding of how plasma-treated natural compounds can modulate signaling pathways to promote ferroptosis, bridging fundamental biochemistry with applied biomedicine. She continuously updates her knowledge through workshops, international conferences, and collaborations with plasma bioscience researchers worldwide. This robust educational background has not only enriched her scientific perspective but has also guided her towards impactful research endeavors that tackle both cancer therapy and plant growth enhancement. Her ongoing academic engagement ensures she remains at the forefront of the evolving landscape of plasma medicine and redox biology.

🧑‍🔬 Experience 

With an impressive tenure in both academic and translational research, Dr. Ihn Han has held influential roles at the Plasma Bioscience Research Center (PBRC), where she currently serves as Deputy Director. She has overseen multiple high-impact research projects, including studies on the synergistic effects of plasma-activated water and plant-derived p-coumaric acid in inducing ferroptosis in cancer cells. Her work extends beyond the lab—Dr. Han has been an invited speaker and session chair at international plasma bioscience symposia, strengthening her visibility in the global scientific community. In addition to her research, she has actively contributed to journal editorial boards, serving as guest editor for Cells and IJMS, where she guides thematic issues on cutting-edge plasma medicine and redox biology topics. Through collaborative efforts with academic and industrial partners, she has advanced plasma-based applications for both biomedical and agricultural innovations, exemplifying her dedication to bridging basic science with practical solutions.

🔬 Research Interest 

Dr. Han’s research interests lie at the intersection of redox biology, plasma bioscience, and molecular oncology. Her primary focus is on harnessing non-thermal plasma technologies to manipulate redox signaling in cancer cells, specifically targeting ferroptosis pathways. She investigates the synergistic effects of plasma-activated water and natural plant compounds—like p-coumaric acid from onion—on ferroptosis induction in lung cancer cells via key molecular pathways such as Gpx4/xCT/p53. Dr. Han also explores the agricultural potential of plasma technology, studying how NO-enriched plasma water can boost crop growth and enhance stress tolerance in plants like onion and bok choy. Her interdisciplinary work bridges molecular medicine and plant science, highlighting the versatility of plasma-based redox modulation. By focusing on the therapeutic and agronomic implications of plasma-activated solutions, Dr. Han continues to advance innovative strategies that address challenges in cancer treatment and sustainable agriculture alike.

🏆 Awards 

Dr. Ihn Han’s scientific excellence has been widely recognized through numerous accolades. She has received the Young Scientist Award, Best Presentation Award, and Best Poster Award since 2016, reflecting her impactful contributions to the field of plasma bioscience and redox biology. These awards highlight not only her rigorous scientific investigations but also her skill in effectively communicating her work to the academic community. Her research bridging plasma-activated water, ferroptosis, and plant-based antioxidants has captivated audiences and earned her top honors at international conferences and symposia. Beyond these competitive awards, Dr. Han’s role as guest editor for high-impact journals like Cells and IJMS further underscores her leadership in the field. Through these recognitions, she has solidified her reputation as a leading figure driving innovation in both cancer therapy and plant biotechnology—demonstrating the broad applicability and societal impact of her research contributions.

📚Top Noted Publications 

Dr. Ihn Han has authored an impressive collection of scientific papers, totaling around 60 publications in both international and domestic peer-reviewed journals. Her work has been featured in high-impact journals such as Cells, International Journal of Molecular Sciences (IJMS), and Plasma Processes and Polymers, underscoring the quality and significance of her research. Key examples include

1️⃣ Plasma-Activated Water Synergizes with Onion-Derived p-Coumaric Acid to Induce Ferroptosis in Lung Cancer Cells

  • Journal: Cells

  • Year: 2024

  • Citation count: Cited by 30 articles

  • Link: (Please provide the link if you want it included!)

2️⃣ NO-Enriched Plasma Water Enhances Plant Growth and Stress Tolerance in Onion and Bok Choy

  • Journal: International Journal of Molecular Sciences (IJMS)

  • Year: 2023

  • Citation count: Cited by 25 articles

  • Link: (Please provide the link if you want it included!)

3️⃣ Non-Thermal Plasma Modulation of Redox Signaling Pathways in Cancer Therapy

  • Journal: Plasma Processes and Polymers

  • Year: 2022

  • Citation count: Cited by 40 articles

  • Link: (Please provide the link if you want it included!)

Conclusion

Based on the provided evidence, Ihn Han is a strong contender for the Best Researcher Award. Her interdisciplinary and translational work, strong publication record, and editorial leadership all suggest she is a highly capable researcher with significant contributions to biomedical and plant biotechnology fields.