Nazia chaudhary | Drug Repurposing | Young Scientist Award

Nazia chaudhary | Drug Repurposing | Young Scientist Award

Dr Nazia chaudhary, ACTREC, TMC, India

Dr. Nazia Chaudhary is a distinguished cancer researcher 🧬 with a Ph.D. focused on pathways promoting tumorigenesis and therapy resistance upon Plakophilin 3 loss 🎗️. Her academic journey includes notable projects on protease-producing thermophiles 🌡️ and mitochondrial function ⚡. She co-holds patents on Lipocalin-2 antibodies 🧪 and has published extensively in high-impact journals 📚, including Redox Biology and FEBS Letters. A DST Inspire Faculty Fellow (2023) 🌟, she has received numerous awards, including the Vaishno Endowment Prize 🏆 and Mahindra Talent Scholarships 🎓. Dr. Chaudhary’s impactful work has been presented globally 🌍, including at Cold Spring Harbor Laboratory, New York.

Publication Profile

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Academic Project

Dr. Nazia Chaudhary is an accomplished researcher with a Ph.D. focused on the project “Characterization of pathways that promote tumorigenesis, radio, and chemo-resistance upon Plakophilin 3 loss.” 💡🧬 She worked on isolating and characterizing protease and antimicrobial-producing thermophiles from Ganeshpuri hot springs at St. Xavier’s College, Mumbai (Jan-Apr 2015). 🌋🔬 Additionally, she contributed to the external project “MKT1 Dependent Regulation of Mitochondrial Function” at Tata Institute of Fundamental Research (May-Aug 2014). 🧪⚙️ Her EXSP project involved isolating and screening thermophilic Actinomycetes for enzymes with industrial importance. 🔍🌡️ Dr. Chaudhary’s diverse research showcases her expertise in microbiology and biotechnology. 🌟

Conference Attended

Dr. Nazia Chaudhary has showcased her research on various esteemed platforms. She presented a poster titled “Screening of Thermophilic Actinomycetes Capable of Producing Enzymes of Industrial Importance” at the Shri Sajjan Gupta Memorial Trophy for Excellence in Biological Science, held on December 11, 2012, at G.N. Khalsa College. Another poster, “Increase in Lipocalin2 Expression Upon Plakophilin3 Loss Confers Chemo and Radioresistance to Tumor Cells,” was presented at the Environmental Mutagen Society of India (EMSI) conference in January 2018 at BARC, Mumbai, and at the prestigious Mechanisms & Models of Cancer meeting in August 2018 at Cold Spring Harbor Laboratory, New York. 🌟🔬📊

Awards and Honors

Dr. Nazia Chaudhary is a distinguished scholar with multiple accolades. She was awarded the prestigious DST Inspire Faculty Award in 2023 and recognized for her research on lipocalin 2 expression and chemo-radiotherapy resistance at the 14th Indo-Australian Biotechnology Conference. She served as a Board of Studies member for Sophia College’s Zoology Department (2018-2021). Throughout her academic journey, she earned various honors, including the Ramidevi Murlidhar Jalan Award 🏆, Saifee Education Aid Scholarship 🎓, and the Mahindra Search for Talent Scholarship 🌟. Her exceptional performance also earned her the Mrs. A. Varghese Prize 🥇 and several other prestigious scholarships and awards.

Patent

Dr. Nazia Chaudhary, along with Sorab N. Dalal, Manjula Das, Sujan K. Dhar, and Smitha P. K., contributed to the development of “Antibodies Against Lipocalin-2 and Use Thereof.” This groundbreaking research led to two key milestones. The first was the PCT application (PCT/IN2020/051068) with publication no. WO/2021/137254 on July 8, 2021. The second was the Indian patent (DBT Indian Patent no: 202021000274) granted on July 30, 2021, published in the Patent Office journal no. 31/2021. These innovations hold significant potential for medical advancements. 🧬💉🧪🔬

Research Focus

Dr. Nazia Chaudhary’s research focuses on the molecular mechanisms of cancer progression, therapy resistance, and invasion, particularly in triple-negative breast cancer (TNBC) and colorectal cancer. She investigates the role of Lipocalin 2 (LCN2) in regulating cellular processes like focal adhesion formation, actin glutathionylation, and ferroptosis inhibition, which are critical for tumor cell migration and resistance to treatment. Her work explores the interplay between signaling pathways, such as Src activation and glutathione metabolism, to uncover potential vulnerabilities in cancer cells. 🧬💥💉🧪🧫

Publication Top Notes

Dr. Rajendra Rohokale|Drug Discovery and Development| Best Researcher Award

Dr. Rajendra Rohokale| Drug Discovery and Development ,Best Researcher Award

Dr. Rajendra Rohokale at university of florida,United States

PROFILE  

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🎓Early Academic Pursuits :

Dr. Rajendra Shankarrao Rohokale embarked on his academic journey with a strong foundation in the sciences, earning his Bachelor of Science in Chemistry from New Arts, Science, and Commerce College, Ahmednagar, affiliated with Savitribai Phule Pune University, Pune, India. His academic pursuit continued with a Master of Science in Organic Chemistry from the same university, where he honed his skills in synthetic organic chemistry, laying the groundwork for his future research endeavors.

During his postgraduate studies, Dr. Rohokale demonstrated a profound interest in organic chemistry, particularly in the areas of synthetic carbohydrate chemistry and glycoscience. His early academic years were marked by a commitment to exploring the complexities of organic compounds, setting the stage for his later achievements in the field.

💼Professional Endeavors :

Dr. Rohokale’s professional journey is characterized by significant contributions to the field of synthetic organic chemistry, with a focus on carbohydrate chemistry, glycoscience, and photoredox catalysis. After completing his Ph.D. in Organic Chemistry from the Department of Chemistry, Savitribai Phule Pune University, he joined the University of Florida as a Research Assistant Professor. Under the mentorship of Prof. Zhongwu Guo, a prominent figure in carbohydrate chemistry, Dr. Rohokale’s work primarily involved the synthesis of complex carbohydrates and their conjugates for therapeutic applications.

Before his tenure at the University of Florida, Dr. Rohokale held a prestigious SERB National Post-doctoral Fellowship at the National Chemical Laboratory, Pune, where he worked under the guidance of Dr. C. V. Ramana. His research during this period focused on the applications of iridium-catalyzed reactions and photoredox catalysis in organic chemistry, contributing to the development of new methodologies in the field.

Dr. Rohokale’s professional experience also includes an international collaboration during the Indigo Program-2012, where he worked on visible light photoredox-catalysis with Prof. Burkhard Koenig at the University of Regensburg, Germany. This collaboration further enriched his research profile, leading to innovative contributions in organic synthesis.

🔬Contributions and Research Focus :

Dr. Rohokale has made significant contributions to the fields of synthetic organic chemistry, carbohydrate chemistry, and photoredox catalysis. His research primarily focuses on developing practical and efficient methods for the chemical and chemoenzymatic synthesis of complex oligosaccharides and glycoconjugates. These include glycoproteins and glycolipids, which are applied to studying related biological and medical problems, such as the functions of glycans and their relationships with diseases.

One of Dr. Rohokale’s notable research contributions is in the area of glycolipids synthesis. His work on glycosylated liposomes for targeted drug delivery and vaccination has potential applications in diagnosing and treating human diseases, including cancer and bacterial infections. His research also extends to the synthesis of biologically relevant molecules, such as GSLs, and their use as probes to explore disease mechanisms.

🏅Accolades and Recognition :

Dr. Rohokale’s academic and research excellence has been recognized through various awards and honors. He was selected for the prestigious SERB National Post-doctoral Fellowship in 2017, acknowledging his potential to contribute to scientific research in India. His selection as a Post-doctoral Fellow at the University of Florida in 2019 further underscores his expertise in carbohydrate chemistry and organic synthesis.

Additionally, Dr. Rohokale has been an active peer reviewer for several high-impact journals, including Chemical Communication and Organic Chemistry Frontiers, published by the Royal Society of Chemistry, and The Journal of Carbohydrate Chemistry, published by the American Chemical Society. His role as a reviewer highlights his standing in the scientific community and his commitment to advancing research in his field.

🌍Impact and Influence :

Dr. Rohokale’s research has had a profound impact on the field of synthetic organic chemistry, particularly in the areas of carbohydrate chemistry and photoredox catalysis. His work on the synthesis of complex carbohydrates and glycoconjugates has implications for medical science, particularly in understanding the role of glycans in diseases and developing new diagnostic tools and therapeutic approaches.

His innovative methodologies in organic synthesis have influenced researchers globally, contributing to the development of new strategies for synthesizing biologically relevant molecules. His collaboration with international institutions, including his work in Germany and the USA, has further extended his influence, making him a respected figure in his field.

🌟Legacy and Future Contributions :

As Dr. Rohokale continues his research at the University of Florida, his legacy in synthetic organic chemistry and carbohydrate research is expected to grow. His contributions to the development of new synthetic methods and their applications in medical science position him as a leading researcher with the potential to make groundbreaking discoveries in the future

🎓Publication 

Diastereoselective 1,3-dipolar intramolecular nitrone olefin cycloaddition (INOC) reaction of a sugar-derived allyl alcohol: Synthesis of functionalized aminocyclopentitols

  • Authors   :Rajendra Rohokale
  • Journal    :
    Carbohydrate Research
  • Year         :2024

Bifunctional glycosphingolipid (GSL) probes to investigate GSL-interacting proteins in cell membranes

  • Authors :Sayan Kundu; Rajendra Rohokale; Chuwei Lin; Sixue Chen; Shayak Biswas; Zhongwu Guo
    • Journal   :
      Journal of Lipid Research
    • Year       : 2024

Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants

  •  Authors  :Rajendra Rohokale; Jiatong Guo; Zhongwu Guo
  • Journal    :
    Journal of Medicinal Chemistry

    Year         :  2024

Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines

  • Authors  :: Rajendra Rohokale; Zhongwu Guo
  • Journal   :
    ACS Infectious Diseases
  • Year        :   2023

Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry

  • Authors  :Gao, T.; Lott, A.A.; Huang, F.; Rohokale, R.; Li, Q.; Olivos, H.J.; Chen, S.; Guo, Z.
  • Journal   :
    Analyst
  • Year        :  2022