Prof. Dr. Ali Darehkordi | Medicinal Chemistry | Research Excellence Award

Vali-e-Asr University of Rafsanjan | Iran

Prof. Dr. Ali Darehkordi is a distinguished Iranian chemist whose academic and professional career reflects deep expertise in organic synthesis, catalysis, drug modification, heterocyclic chemistry, and the design of biologically active fluorinated compounds. He holds a Ph.D., M.Sc., and B.Sc. in Organic Chemistry and Chemistry from leading Iranian universities, with a strong foundational background in natural sciences. Beginning his academic journey as an instructor in the Faculty of Science at Vali-e-Asr University of Rafsanjan, he steadily advanced through key academic ranks, serving as Assistant Professor, Associate Professor, and ultimately Professor of Organic Chemistry. Throughout his career, he has also held several important administrative and leadership roles, including Deputy of the Faculty of Science, Director of the Department of Chemistry, and repeated appointments as Head of the Faculty of Basic Sciences, where he contributed to academic development, departmental management, curriculum enhancement, and research advancement.Prof. Darehkordi’s research accomplishments have earned him multiple awards, including several Excellent Researcher Awards at the faculty, departmental, and university levels, recognizing his contributions to both scientific research and industrial collaboration. His scientific interests span a wide range of advanced topics, such as the design, synthesis, and biological evaluation of trifluoromethylated heterocyclic compounds with anticancer potential, catalysis reactions, drug modification using trifluoroacetimidoyl chlorides, organic synthesis pathways, carbohydrate reaction mechanisms, and herbal medicine applications. His laboratory expertise includes hands-on proficiency with NMR, FT-IR, microwave reactors, ultrasound systems, and polarimetry, supporting his ability to conduct complex chemical characterizations and innovative synthesis techniques.As an active researcher with extensive contributions to international journals, Prof. Darehkordi has authored impactful publications, including A novel bistrifluoromethylated compound as highly efficient nematicide against root-knot nematode on pistachio and docking study, Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies, and A facile and catalyst-free microwave-promoted method for the synthesis of 3-trifluoromethyl 1,2,4-triazole-5-thiones. These publications highlight his innovative chemical synthesis approaches, application-driven research mindset, and strong integration of computational docking, biological testing, and modern reaction methodologies. Prof. Dr. Ali Darehkordi continues to stand as a leading scientist in organic and medicinal chemistry, contributing meaningfully to drug discovery, reaction design, and fluorinated molecule development.

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Featured Publications

Moghadam, M. R., Jahromi, S. M. P., & Darehkordi, A. (2016). Simultaneous spectrophotometric determination of copper, cobalt, nickel and iron in foodstuffs and vegetables with a new bis thiosemicarbazone ligand using chemometric approaches. Food Chemistry, 192, 424–431.

Darehkordi, A., Saidi, K., & Islami, M. R. (2007). Preparation of heterocyclic compounds by reaction of dimethyl and diethyl acetylene dicarboxylate (DMAD, DEAD) with thiosemicarbazone derivatives. Arkivoc, 1, 180–188.

Darehkordi, A., Rahmani, F., & Hashemi, V. (2013). Synthesis of new trifluoromethylated indole derivatives. Tetrahedron Letters, 54(35), 4689–4692.

Funt, L. D., Tomashenko, O. A., Novikov, M. S., & Khlebnikov, A. F. (2018). An azirine strategy for the synthesis of alkyl 4-amino-5-(trifluoromethyl)-1H-pyrrole-2-carboxylates. Synthesis, 50(24), 4809–4822.

Karimabad, M. N., Mahmoodi, M., Jafarzadeh, A., Darehkordi, A., Hajizadeh, M. R., et al. (2017). The novel Indole-3-formaldehyde (2-AITFEI-3-F) is involved in processes of apoptosis induction? Life Sciences, 181, 31–44.

Karimabad, M. N., Mahmoodi, M., Jafarzadeh, A., Darehkordi, A., Hajizadeh, M. R., et al. (2017). Evaluating of OCT-4 and NANOG was differentially regulated by a new derivative indole in leukemia cell line. Immunology Letters, 190, 7–14.