Dr. Dmitry Gushchin | Gene Therapy | Lifetime Achievement Award
Lead scientist at Sirius University of Science and Technology | Russia
Dr. Dmitry Gushchin is a molecular biologist and genome engineering expert with over three decades of international research and leadership experience. He has made pioneering contributions to CRISPR systems, zinc-finger nucleases, and chromatin biology. Currently serving as Lead Scientist at Sirius University of Science and Technology, he leads translational medicine and colloidal medicine research. His career spans prominent institutions including Sangamo BioSciences, NIH, École Polytechnique, and the Institute for Basic Science. Dr. Gushchin has authored numerous high-impact publications, holds multiple U.S. patents, and has significantly advanced technologies in gene editing, cancer biology, and translational medicine with global scientific impact.
Publication Profile
Google Scholar
Education
Dr. Dmitry Gushchin earned his Master of Science in Molecular and Chemical Physics from the Moscow Institute of Physics and Technology, where he developed a strong foundation in biophysics and molecular mechanisms. He completed his Ph.D. in the Chromosome Structure Laboratory at the Engelhardt Institute of Molecular Biology, Moscow, focusing on chromatin biology and the role of histone modifications in transcriptional regulation. His academic training combined rigorous molecular biology, genome regulation, and structural biochemistry, which later evolved into groundbreaking applied research in gene editing technologies. This strong educational foundation equipped him to bridge fundamental biology with advanced translational medicine applications.
Experience
Dr. Dmitry Gushchin has held key scientific positions worldwide, including Lead Scientist at Sirius University, Assistant Professor at Nazarbayev University, and Senior Research Scientist at the Moscow Institute of Physics and Technology. His career also includes impactful roles as Research Engineer at École Polytechnique, Research Fellow at the Institute for Basic Science in Korea, and Scientist at Sangamo BioSciences, where he co-authored more than 20 peer-reviewed articles and obtained 10 U.S. patents. Earlier roles include visiting scientist positions at NIH, Argonne National Laboratory, and Imperial Cancer Research Fund, where he contributed to discoveries in chromatin biology, interferon signaling, and genome engineering.
Awards and Honors
Dr. Dmitry Gushchin scientific excellence has been recognized through multiple achievements and honors. At Sangamo BioSciences, he obtained 10 U.S. patents for innovations in genome mutation detection and targeted deletions with zinc-finger nucleases. His pioneering research has been published in top journals such as Nature, Cell, Science, and Nature Biotechnology. He contributed to developing CRISPR-Cpf1 systems with new PAM specificities and established key methods for base editing. His discoveries in interferon signaling and nucleosome mobilization have been highly influential. In addition, he received competitive international funding, including grants for whole-genome screening in oncology, underscoring his role as a leading innovator in biomedicine.
Research Focus
Dr. Dmitry Gushchin research focuses on genome engineering, translational medicine, and molecular mechanisms of disease. He has developed cutting-edge technologies in gene editing, including zinc-finger nucleases, CRISPR-Cpf1 systems, and base editing strategies. His work advances cancer biology through functional studies on tumor cell motility, knockout models, and circulating tumor DNA biomarkers. In translational medicine, he integrates nanotechnology, colloidal systems, and genetic tools for precision therapy. He also explores chromatin regulation, interferon signaling, and epigenetic dynamics. By combining fundamental molecular biology with applied biomedical innovation, Dr. Gushchin drives progress in personalized medicine, cancer therapeutics, and next-generation genetic engineering strategies.
Publication Top Notes
An improved zinc-finger nuclease architecture for highly specific genome editing
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
DNA analysis and diagnostics on oligonucleotide microchips.
A rapid and general assay for monitoring endogenous gene modification
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
Oligonucleotide microchips as genosensors for determinative and environmental studies in microbiology
Chromatin structural features and targets that regulate transcription
Translating dosage compensation to trisomy 21
Manual manufacturing of oligonucleotide, DNA, and protein microchips
Conclusion
Dr. Dmitry Gushchin embodies the qualities of a scientist whose career achievements merit recognition through the Research Lifetime Achievement Award. His groundbreaking innovations in genome engineering, molecular medicine, and translational research have advanced the frontiers of biotechnology and medical science. While there is potential for even greater global visibility and clinical translation, his sustained excellence, pioneering discoveries, and international scientific contributions make him an outstanding candidate for this distinguished honor.