Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award Published on 15/06/202415/06/2024 by Top Pharmaceutical Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award Dr.Careen Liza Pakyntein, at NORTH EASTERN HILL UNIVERSITY,India Author Profile Scopus Skills⚡ 🌿 Phytochemical Profiling ⚗️ Gas Chromatography 🧪 Flash Chromatography 🧬 Thin Layer Chromatography 💉 High-Performance Liquid Chromatography (HPTLC) 🧫 Conventional Polymerase Chain Reaction (PCR) 🧬 Real-Time Polymerase Chain Reaction (RT-PCR) ⚡ Electrophoresis Techniques: SDS-PAGE, PFGE 🧬 DNA/RNA/Protein Isolation 🧬 Western Blotting 🧫 Biochemical Analysis 🐭 Mice Handling 🧬 ADME-TOX Profiling 🔬 Immunohistochemistry 🔬 Microscopy 🧫 Microbiology 🧫 Cell Culture Experience🧑🔬 Project Scientist- IBSD, Manipur (March 2024 – Present) Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables. Project Associate-I Division of Animal and Fisheries Sciences, ICAR-RC NEH, Umiam (December 2021 – June 2023) Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables. Research Scholar Department of Biochemistry, NEHU, Shillong (February 2017 – November 2021) Duties: Drafting research proposals, research data collection, analysis, documentation, interpretation, paper presentation at national and international conferences, paper writing and publication, supervised and mentored PG students for dissertation projects. Education📚 Ph.D. in Biochemistry North-Eastern Hill University, Shillong (August 2023) M.Sc. in Biochemistry North-Eastern Hill University, Shillong (August 2016) B.Sc. in Biochemistry St. Anthony’s College, Shillong (June 2014) AISSCE (Science) Kendriya Vidyalaya Laitkor Peak, Shillong (May 2011) SSLC Hill Crest Higher Secondary School, Shillong (May 2009) Publications 📄 Syiem, A.B., Pakyntein, C.L., Syiem, D., Thabah D. “Amelioration of carbohydrate and fat metabolism by Houttuynia cordata and Hypochaeris radicata in alloxan-induced diabetic mice.” International Journal of Pharmacological Research (2022); 12(5): e5743. Sunn, S.E., Syiem, D., Pakyntein, C.L. “Amelioration of altered adipokines expression and serine/threonine phosphorylation of IRS1 in alloxan-induced diabetes by Potentilla fulgens and its phytochemical constituents.” GSC Biological and Pharmaceutical Sciences (2021); 17(03): 144–152. Pakyntein, C.L., Syiem, D., Thabah D., Sunn, S.E. “Antioxidant, anti-inflammatory and antihyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study.” GSC Biological and Pharmaceutical Sciences (2021); 16(03): 145–154. Saio, V., Syiem, D., Sharma, R., Pakyntein, C.L. “Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice.” Clinical Phytoscience (2021); 7:6. Thabah, D., Syiem, D., Pakyntein, C.L., Banerjee, S., Kharshiiing, C.E., Bhattacharjee, A. “Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study.” Archives of Physiology and Biochemistry (2021); 129(5): 1071-1083. Wankhar, W., Syiem, D., Pakyntein, C.L., Thabah, D., Sunn S.E. “Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) – Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.” Behavioural Brain Research (2020); 393: 112780. 🎓Publication Top Noted: Paper Title : Potentilla fulgens Upregulate GLUT4, AMPK, AKT, and Insulin in Alloxan-Induced Diabetic Mice: An In Vivo and In Silico Study 🧬📊 Co-Authors: Syiem, D., Pakyntein, C.L., Kharshiing, C.E., Bhattacharjee, A. Journal: Archives of Physiology and Biochemistry Year: 2023 Summary: This study investigates the potential of Potentilla fulgens in regulating key metabolic pathways in diabetic mice, highlighting its ability to upregulate important proteins and enzymes involved in glucose metabolism. Paper Title :Effect of 5-HT2C Receptor Agonist and Antagonist on Chronic Unpredictable Stress (CUS) – Mediated Anxiety and Depression in Adolescent Wistar Albino Rat: Implicating Serotonin and Mitochondrial ETC-I Function in Serotonergic Neurotransmission 🧠🔬 Co-Authors: Wankhar, W., Syiem, D., Pakyntein, C.L., Sunn, S.E. Journal: Behavioural Brain Research Year: 2020 Summary: This research explores the role of 5-HT2C receptors in anxiety and depression caused by chronic unpredictable stress, emphasizing the connection between serotonergic neurotransmission and mitochondrial function.