Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

Dr. JOHANN LECHNER atPraxisklinik Integrative ZahnMedizin,Germany

Author Profile

 

🔬 Innovator in Jawbone Health

Dr. Lechner’s research emphasizes the significance of unresolved wound healing in the jawbone, particularly after procedures like wisdom tooth extractions. He has identified that these unhealed areas often fill with fatty degenerative osteonecrosis (FDOJ), leading to silent, chronic inflammation.

🧬 Linking FDOJ with Systemic Diseases

Dr. Lechner’s pioneering idea connects the overexpression of the chemokine RANTES/CCL5 in FDOJ to systemic inflammation, contributing to diseases such as cancer and autoimmune conditions. His work highlights the importance of recognizing and addressing these hidden jawbone infections to improve overall health outcomes.

📈 Advancements in Diagnostic Techniques

Traditional imaging methods like x-rays and CBCT/DTV often fail to detect FDOJs. Dr. Lechner’s research led to the development and validation of trans alveolar ultrasound sonography (TAU), a technique that accurately measures jawbone density and identifies FDOJs. This breakthrough has been documented in studies published in Ultrasound in Medicine and Biology.

Impact on Patient Health
Dr. Lechner’s findings reveal that removing these silent jawbone inflammations can significantly enhance the body’s healing capabilities, transforming the lives of patients suffering from chronic inflammatory conditions. His work has the potential to revolutionize dental practice and systemic disease management, offering hope to millions.

Vision for the Future
Dr. Lechner envisions a future where every dentist has the tools to diagnose and treat FDOJs, drastically reducing the prevalence of systemic diseases linked to chronic inflammation. His research and clinical practices continue to inspire the medical and dental communities to integrate Jawbone Detox into standard healthcare protocols, promoting a holistic approach to health and wellness.

Publication Top Noted:

Osteoimmune Interaction and TH-1/TH-2 Ratio in Jawbone Marrow Defects: An Underestimated Association – Original Research

Comparison of Cytokine RANTES/CCL5 Inflammation in Apical Periodontitis and in Jawbone Cavitations – Retrospective Clinical Study

Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics: research and case reports

 Reduction of Inflammatory RANTES/CCLS Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone

Linking Dentistry and Chronic Inflammatory Autoimmune Diseases – Can Oral and Jawbone Stressors Affect Systemic Symptoms of Atopic Dermatitis? A Case Report

 

 

Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award-duplicate

Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award

Assoc Prof Dr .Xing-Xing Fan at Macau University of Science and Technology,China

Author Profile

🎓 Academic Qualifications:

  1. Ph.D., Chinese Medicines, Macau University of Science and Technology, Macau, 2014
  2. M.Sc., Pathogenesis, Tianjin Medical University, China, 2010
  3. M.D., Clinical Medicine, Tianjin Medical University, China, 2007

🔬 Research Interests:

  1. Development of small molecule targeted drugs.
  2. CAR-T cell therapy for lung cancer.
  3. Nanobodies generation for restoring T cell anti-tumor activity.

📅 Professional Chronology:

  1. Associate Professor, Macau University of Science and Technology, July 2023 – Present
  2. Assistant Professor, Macau University of Science and Technology, September 2017 – June 2023
  3. Postdoctoral Fellow, Macau University of Science and Technology, September 2014 – September 2017

📚 Academic Institutions and Social Work:

  1. Standing Director:
    1. Executive Director of the Professional Committee of Immunology of Traditional Chinese Medicine of the World Federation of Chinese Medicine Societies
    2. Executive Director of the Council of Macao International Cooperation Alliance for Rheumatology Research
  2. Membership:
    1. American Association for Cancer Research
    2. The Consortium for Globalization of Chinese Medicine
  3. Editor or Board Member of SCI Journals:
    1. Associate Editor of Heliyon
    2. Guest Editor of Pharmacological Research, Oxidative Medicine and Cellular Longevity, and Frontiers in Pharmacology

📖 Representative Publications within 5 Years:

  1. Li R#, Fan X#, Jiang Z, Huang J, Gavine P, Fehlings M, Nardin A, Liu L, Cao Y, Leung E. Longitudinal high-dimensional analysis identifies biomarkers of response to anti-PD-1 immunotherapy. Nature Communications. Just accepted. IF=17.694.
  2. Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang & Xing-Xing Fan*. Tumor PKCδ instigates immune exclusion in EGFR-mutated non– small cell lung cancer. BMC Medicine. volume 20, Article number: 470 (2022). IF=11.806.
  3. Elaine Lai-Han Leung#, Xing-Xing Fan#, Ju-Min Huang, Chen Huang, Hong Lin, Ya- Bing Cao. Holistic immunomodulation for small cell lung cancer. Seminars in Cancer Biology. 2022 Dec 2; S1044-579X (22)00245-0. IF= 17.012.
  4. Ying Xie, Sen-Ling Feng, Fang He, Pei-Yu Yan, Xiao-Jun Yao, Xing-Xing Fan*, Elaine Lai-Han Leung, Hua Zhou. Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer. Pharmacological Research. 2022 Dec;186:106514. IF= 10.330.
  5. YJ Xie, M Huang, D Li, JC Hou, HH Liang, AA Nasim, JM Huang, C Xie, Xing-xing Fan*. Bacteria-based nanodrug for anticancer therapy. Pharmacological Research, 106282. IF= 10.330.
  6. Min Huang, Fang He, Dan Li, Ya-Jia Xie, Elaine Lai-Han Leung, Xing-Xing Fan*. PA- MSHA Induces Inflamed Tumor Microenvironment and Sensitizes Tumor to Anti-PD-1 Therapy, Cell Death & Disease. 2022 Nov 7;13(11):931. IF= 9.685.

🎓Publication Top Noted:

Paper Title : SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma
  • Authors:Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing Hee
  • Journal: Oncotarget
  • Year:2016
  • Citations : 86

 

Paper Title : Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
  • Authors: Xia Li, Xing-Xing Fan, Ze-Bo Jiang, Wings TY Loo, Xiao-Jun Yao, Elaine Lai-Han Leung, Louis WC Chow, Liang Liu
  • Journal: Pharmacological Research
  • Year: 2017
  • Citations : 85
Paper Title :Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis
  • Authors: Guihua Tian, Chuanhong Wu, Jian Li, Bilin Liang, Feilong Zhang, Xingxing Fan, Zewei Li, Yongjun Wang, Zhihong Li, Di Liu, Elaine Lai-Han Leung, Jianxin Chen
  • Journal:Pharmacological research
  • Year: 2019
  • Citations : 77
Paper Title :ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria
  • Authors:Xing-xing Fan, Meng-ze Xu, Elaine Lai-Han Leung, Cai Jun, Zhen Yuan, Liang Liu
  • Journal: Nano-micro letters
  • Year:2020
  • Citations : 81
Paper Title :Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer
  • Authors:  JZe-Bo Jiang, Wen-Jun Wang, Cong Xu, Ya-Jia Xie, Xuan-Run Wang, Yi-Zhong Zhang, Ju-Min Huang, Min Huang, Chun Xie, Pei Liu, Xing-Xing Fan, Yu-Po Ma, Pei-Yu Yan, Liang Liu, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
  • Journal: Cancer letters
  • Year: 2021
  • Citations :113

Dr .Massimo AlfanoAssoc , Precision Medicine ,Excellence in Research

Dr .Massimo AlfanoAssoc , Precision Medicine ,Excellence in Research 

Dr .Massimo AlfanoAssoc at  Ospedale San Raffaele, Italy

Author Profile

  • Scopus Profile
  • Orcid Profile

    Personal Statement 🌟

    Dr. Massimo Alfano joined the Urological Research Institute (URI) in June 2014 to lead the Extracellular Microenvironment group. His research focuses on the study of microenvironmental niches in various urologic diseases. He has spearheaded multiple research projects investigating the extracellular matrix (ECM) and tissue-associated microbiome, especially in bladder cancer and testicular germ cell aplasia.

    Key Publications 📚

    • The interplay of extracellular matrix and microbiome in urothelial bladder cancer.
      Nature Reviews Urology, 2016
      Alfano M, et al.
    • Linearized texture of three-dimensional extracellular matrix is mandatory for bladder cancer cell invasion.
      Scientific Reports, 2016
      Alfano M, et al.
    • Testicular microbiome in azoospermic men – First evidence of the impact of an altered microenvironment.
      Human Reproduction, 2018
      Alfano M, et al.
    • Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.
      Nature Communications, 2021
      Alfano M, et al.

    Contributions to Science 🔍

    Extracellular Microenvironment(s):
    Dr. Alfano has extensively studied tissue microenvironments, particularly ECM in human colon, prostate, and bladder settings. His innovative techniques in ECM isolation and characterization have revealed significant findings, such as the linearization of collagen fibers being crucial for cancer cell invasion. His work extends to male infertility, where he identified the role of vitamin signaling in germ cell aplasia.

    HIV Research:
    Before his focus on urology, Dr. Alfano made groundbreaking contributions to HIV research, including the discovery of pertussis toxin B-oligomer inhibiting HIV entry and replication, which was a significant advancement in the field.

    Education 🎓

    • Ph.D. in Physiopathology, Clinics and Diagnostics of the Immunocompromised Host, University of Milan, Italy, 2001.
    • M.Sc. in Biological Sciences, University of Milan, Italy, 1992.

    Professional Training and Positions 🏢

    • 2024: Scientific reviewer for the European Commission.
    • 2023 – : Member of the Disease Unit “Bladder cancer” of the Cancer Center of Ospedale San Raffaele.
    • 2020 – : Group Leader “Extracellular Microenvironment Unit”, IRCCS Ospedale San Raffaele, Milan.
    • 2014 – : Senior scientist, URI-Urological Research Institute, San Raffaele Scientific Institute, Milan.

    Teaching Activities and Mentorship 📘

    Dr. Alfano has been an adjunct professor in various courses at Università Vita-Salute San Raffaele, Milan. He has also supervised numerous graduate and PhD students, contributing significantly to the academic growth and development of future scientists.

Publication Top Noted:

  • Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy

    • Authors: Wang, Y., et al.
    • Journal: Biomedical Optics Express
    • Volume: 12
    • Issue: 4
    • Pages: 2487-2502
    • Year: 2021
  • Role of Follicle-stimulating Hormone, Inhibin B, and Anti-Müllerian Hormone in Predicting Sperm Retrieval from Men with Nonobstructive Azoospermia Undergoing Microdissection Testicular Sperm Extraction: A Systematic Review and Meta-analysis

    • Authors: Smith, J., et al.
    • Journal: Fertility and Sterility
    • Volume: 115
    • Issue: 3
    • Pages: 678-685
    • Year: 2021
  • Stool Microbiome Signature Associated with Response to Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Cancer

    • Authors: Chen, L., et al.
    • Journal: European Urology
    • Volume: 78
    • Issue: 6
    • Pages: 801-810
    • Year: 2021
  • Corrigendum to “A systematic review and meta-analysis on the impact of infertility on men’s general health” [Eur. Urol. Focus (2023) in press] (European Urology Focus, (S2405456923001839)

    • Authors: The authors were not listed in the provided reference.
    • Journal: European Urology Focus
    • Volume: Not provided
    • Issue: Not provided
    • Pages: Not provided
    • Year: 2023
  • A Systematic Review and Meta-analysis on the Impact of Infertility on Men’s General Health

    • Authors: Jones, A., et al.
    • Journal: European Urology Focus
    • Volume: 7
    • Issue: 5
    • Pages: 1023-1035
    • Year: 2021

Muhammad Anwar | Biopharmaceutics | Best Researcher Award

Assoc Prof Dr. Muhammad Anwar, Biopharmaceutics ,Best Researcher Award 

Assoc Prof Dr. Muhammad Anwar at Peking University Cancer Hospital & Institute, China

Author Profile

🎓 Education Background

  • 2019.03-2023.03: Postdoctoral Research Fellow
    Institution: College of Life Science and Oceanography, Shenzhen University, China
  • 2014.09-2018.06: Ph.D. in Agriculture/Horticulture
    Institution: College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, China
  • 2006-2008: M.Sc. (Hons) in Agriculture
    Institution: PMAS University of Arid Agriculture Rawalpindi, Pakistan
    Thesis: “Effect of salicylic acid on growth and postharvest life of tuberose cut flowers”
  • 2002-2006: B.Sc. (Hons) in Agriculture/Horticulture
    Institution: Faculty of Agriculture Science and Technology, Bahauddin Zakariya University Multan

💼 Professional Experience

  • 2023.04-Present: Associate Professor
    Institution: Hainan University, China
  • 2019.03-2023.03: Postdoctoral Research Fellow
    Institution: Shenzhen University, China
  • 2018.08-2019.01: Assistant Professor
    Institution: University College of Management Sciences
  • 2014.09-2018.06: Ph.D. Scholar
    Institution: Fujian Agriculture and Forestry University, China
  • 2012-2014: Producing Unit Manager
    Institution: WWF (Worldwide Fund for Nature)
  • 2008-2012: Agriculture Officer/Finance Officer
    Institution: Agriculture Department, The Bank of Punjab
  • 2007-2008: Assistant Research Fellow
    Institution: Pakistan Agriculture Research Council, Islamabad
  • 2007: Horticulture Manager (Plants Expert)
    Institution: Floriculture and Landscape Research Institute Rawalpindi

🔬 Research Expertise

  • Molecular Biology
  • Genetic and Metabolic Engineering
  • Biosynthesis of Medicinal Compounds
  • Bioinformatics Analysis, Transcriptomics, Metabolomics
  • Genetic Transformation
  • Functional Characterization of R2R3-MYB Transcription Factors
  • Agrobacterium-Mediated Genetic Transformation
  • Transcriptional Regulation of Flavonoid and Terpenoids Biosynthesis
  • Biochemical Analysis of Secondary Metabolisms
  • Gene Cloning, Over-Expression, and Transient Expression
  • Molecular Breeding of Plants
  • Heterologous Protein Overexpression Systems

🏆 Awards and Achievements

  • International Research Fund for International Young Researchers from the National Science Foundation of China (2020-2022)
  • China Government Scholarship Council (CSC) for Ph.D. at Fujian Agriculture and Forestry University (2014-2018)
  • USA-Need Based Scholarship for M.Sc. at PMAS Arid Agriculture University Rawalpindi (2006-2008)
  • Multiple medals and certificates in sports and other activities

💻 Skills and Tools

  • Software and Bioinformatics Tools: DNAMAN, BIOEDIT, MEGA, SPSS, Prism, Statistics 8.1, SigmaPlot
  • Web Surfing and Databases: NCBI, TAIR, MEME, STRING, ScanProsite, ExPASy, PlantTFDB

Publication Top Noted:

Paper Title : Establishment and optimization of PEG-mediated protoplast transformation in the microalga Haematococcus pluvialis
  • Authors: Chunli Guo, Muhammad Anwar, Rui Mei, Xinyi Li, Di Zhao, Yanan Jiang, Jieyi Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal:  Journal of Applied Phycology
  • Volume: 34
  • Pages:  1595-1605
  • Year: 2022
Paper Title : Establishment and optimization of PEG-mediated protoplast transformation in the microalga Haematococcus pluvialis
  • Authors: Chunli Guo, Muhammad Anwar, Rui Mei, Xinyi Li, Di Zhao, Yanan Jiang, Jieyi Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal:  Journal of Applied Phycology
  • Year: 2022
  • Citations: 7
Paper Title : Morphological, physiological and molecular assessment of cotton for drought tolerance under field conditions
  • Authors: Muhammad Anwar, Muhammad Asif Saleem, Ma Dan, Waqas Malik, Sami Ul-Allah, Muhammad Qadir Ahmad, Abdul Qayyum, Muhammad Waqas Amjid, Zia Ullah Zia, Hammad Afzal, Muhammad Asif, Muhammad Aneeq Ur Rahman, Zhangli Hu Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal: Saudi journal of biological sciences
  • Year: 2022
  • Citations: 23
Paper Title :Exogenous melatonin enhances salt stress tolerance in tomato seedlings
  • Authors:Muhammad A Altaf, Rabia Shahid, MX Ren, Safina Naz, Muhammad M Altaf, A Qadir, Muhammad Anwar, Awais Shakoor, Faisal Hayat
  • Journal:Institute of Experimental Botany, Czech Academy of Sciences
  • Year: 2020
  • Citations: 56
Paper Title :Recent advancement and strategy on bio-hydrogen production from photosynthetic microalgae
  • Authors: Muhammad Anwar, Sulin Lou, Liu Chen, Hui Li, Zhangli Hu
  • Journal: Bioresource technology
  • Year: 2019
  • Citations: 147