Lior Zangi | Drug Discovery and Development | Best Researcher Award

Lior Zangi | Drug Discovery and Development | Best Researcher Award

Prof. Lior Zangi, Icahn School of Medicine at Mount Sinai, United States

Prof. Lior Zangi is an Associate Professor of Cardiology and Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai, NY. He earned his Ph.D. in Immunology from the Weizmann Institute and completed postdoctoral training at Harvard Medical School. Renowned for his pioneering work in mRNA-based cardiovascular therapies, Prof. Zangi has received prestigious awards including the AHA Postdoctoral Fellowship and an endowed professorship in Cardiovascular Research. He is a founding board member of the Society for RNA Therapeutics and actively contributes to global scientific councils, manuscript reviews, and grant panels.

Publication Profile

Google Scholar

Education

Prof. Lior Zangi ๐ŸŽ“ began his academic journey with a B.Sc. in Biology from the Hebrew University, Givat-Ram, Jerusalem in 2000. He then earned his M.Sc. in Experimental and Developmental Medicine in 2003 from the Hebrew University Hadassah-Medical School under the guidance of Prof. Raphael Gorodetsky. In 2009, he completed his Ph.D. in Immunology at the Weizmann Institute of Science, mentored by Prof. Yair Reisner. ๐ŸŒฟ He continued his training as a postdoctoral fellow at Sheba Medical Center (2009โ€“2010) under Prof. Benjamin Dekel and later at Harvard Medical School (2010โ€“2014) with Professors Derrick Rossi and Kenneth Chien.

Awards

Prof. Lior Zangi ๐ŸŒŸ has earned numerous prestigious honors throughout his career. He received the ASH Travel Award in both 2008 and 2009 ๐Ÿงณ, and in 2009, was granted a Postdoctoral Fellowship Award by the Israeli Budgeting Committee and Planning. In 2012, he was honored with both the ISSCR Travel Award and R&D Systems Travel Grant โœˆ๏ธ. His groundbreaking postdoctoral work earned him the AHA Fellowship Award in 2014 ๐Ÿซ€. In 2017, he received the Mount Sinai Faculty Idea Prize ๐Ÿง , and in 2019, his research on mRNA therapy was recognized as highly influential ๐Ÿ“œ. In 2023, he was awarded the Endowed Chan Soon-Shiong Professorship in Cardiovascular Research ๐Ÿ….

Research Focus

Prof. Lior Zangi is a pioneering researcher in cardiovascular regenerative medicine, with a special focus on modified mRNA therapies, ๐Ÿงฌ stem cell biology, and ๐Ÿซ€ cardiac regeneration. His work centers on developing innovative strategies for repairing damaged heart tissue using modRNA, induced pluripotent stem cells (iPSCs), and heart-on-chip technologies. Zangiโ€™s groundbreaking research has contributed to advancements in treating conditions like myocardial infarction and Barth syndrome, and has broad implications for tissue engineering, ๐Ÿ’‰ protein replacement therapy, and immune modulation. His contributions are reshaping modern precision medicine and offering new hope for heart failure patients worldwide.

Publication Top Notes

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Isolation of mesenchymal stem cells from G-CSF-mobilized human peripheral blood using fibrin microbeads

Direct imaging of immune rejection and memory induction by allogeneic mesenchymal stromal cells

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells

Isolation and characterization of nontubular sca-1+ linโˆ’ multipotent stem/progenitor cells from adult mouse kidney

Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration

mRNA-based protein replacement therapy for the heart

Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction

Roxana Matran | Pharmacology | Best Researcher Award

Roxana Matran | Pharmacology | Best Researcher Award

Assist Prof Dr Roxana Matran, UMF “Carol Davila”, Romania

Dr. Roxana Matran is a distinguished pediatric gastroenterologist and academic with a Ph.D. from Carol Davila University of Medicine and Pharmacy (2017) ๐ŸŽ“. An Assistant Professor at the same university since 2019, she excels in teaching and research on pediatric pulmonology and gastroenterology. Her clinical expertise at “Grigore Alexandrescu” Emergency Hospital for Children includes contributions to groundbreaking clinical trials on inflammatory bowel diseases ๐Ÿฅ๐Ÿ”ฌ. A dedicated volunteer with MD Caravana cu Medici ๐Ÿค, she brings healthcare to underserved communities. Dr. Matranโ€™s active membership in ESPGHAN and advisory roles showcase her impactful influence in public health policy ๐ŸŒโœจ.

Publication Profile

orcid

Educational Backgrounds

Assist. Prof. Dr. Roxana Matran embarked on her academic journey at the prestigious Central School in Bucharest, where she specialized in Mathematics-Informatics with bilingual French instruction (๐Ÿ“˜โœ๏ธ). She continued her education at “Carol Davila” University of Medicine and Pharmacy, earning a Bachelor’s Degree in 2009 (๐ŸŽ“๐Ÿฉบ). Driven by her passion for medicine, she pursued a Ph.D. at the same university, completing her thesis on factors contributing to pulmonary disease in cystic fibrosis between 2013 and 2017 (๐Ÿ“„๐Ÿซ). Her dedication and expertise in the medical field have solidified her reputation as a leading academic and researcher in Bucharest (๐ŸŒŸ๐Ÿฅ).

Work Experiance

Assist. Prof. Dr. Roxana Matran is a distinguished pediatric gastroenterologist and academic based in Bucharest. She serves as a member of the Advisory Committee on Post-Vaccination Adverse Reactions, analyzing vaccine-related health concerns (๐Ÿ’‰๐Ÿ“Š). She is also a sub-investigator in pivotal clinical trials, including studies on Vedolizumab and Adalimumab for pediatric Crohnโ€™s disease and ulcerative colitis (๐Ÿ”ฌ๐Ÿ“‘). Dr. Matran volunteers with Caravana cu Medici, offering medical consultations in underserved Romanian villages (๐Ÿš‘๐Ÿค). As an Assistant Professor at “Carol Davila” University, she teaches fifth-year medical students and conducts extensive research (๐Ÿ“š๐Ÿ‘ฉโ€๐Ÿ”ฌ). Her work at “Grigore Alexandrescu” Emergency Hospital focuses on consultations, rounds, and clinical studies (๐Ÿฅ๐Ÿ‘ถ).

Membership

Assist. Prof. Dr. Roxana Matran is an active member of esteemed professional organizations in her field. Since June 2019, she has been a Full Member of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN), contributing to advancements in pediatric healthcare across Europe (๐ŸŒ๐Ÿ‘ถ๐Ÿฉบ). Additionally, she has been a dedicated member of the Romanian Society of Pediatrics since July 2016, working to promote excellence in pediatric medicine and research in her home country (๐Ÿ‡ท๐Ÿ‡ด๐Ÿ“š๐Ÿ’‰). Her involvement in these societies underscores her commitment to improving children’s health and staying at the forefront of medical advancements (๐ŸŒŸ๐Ÿ”ฌ).

Conference and Seminars

Assist. Prof. Dr. Roxana Matran has an extensive track record of participation in prestigious medical events and specialized training programs worldwide. In 2024, she is set to attend the 5th Liver Transplant School in Brussels (25โ€“28 September) and the ESPGHAN Mastercourse in Parenteral Nutrition in Linz, Austria (4โ€“6 March). Her prior engagements include the ESPGHAN IBD Masterclass in Helsinki, Finland (2022) and the International Symposium on Pediatric Inflammatory Bowel Disease in Edinburgh, Scotland (2022). Over the years, she has honed her expertise in pediatric gastroenterology, nutrition, and pulmonology, attending courses in Italy ๐Ÿ‡ฎ๐Ÿ‡น, Austria ๐Ÿ‡ฆ๐Ÿ‡น, France ๐Ÿ‡ซ๐Ÿ‡ท, and Greece ๐Ÿ‡ฌ๐Ÿ‡ท, and even completing a post-graduate program online ๐ŸŒ.

Community Impact

Assist. Prof. Dr. Roxana Matran is deeply committed to serving underserved communities, demonstrating her passion for equitable healthcare access. She actively volunteers with MD Caravana cu Medici, a noble initiative providing essential medical consultations in impoverished Romanian villages ๐Ÿก. Through this work, Dr. Matran brings her expertise in pediatric gastroenterology and nutrition to those who need it most, offering care, guidance, and hope ๐ŸŒŸ. Her dedication to improving public health goes beyond the clinic, reflecting a strong sense of compassion and responsibility toward marginalized populations ๐Ÿค. Dr. Matranโ€™s efforts exemplify the true spirit of community service and medical care โค๏ธ.

Clinical Expertise

Assist. Prof. Dr. Roxana Matran has made significant contributions to pediatric gastroenterology through her clinical practice, research, and involvement in clinical trials. As a pediatric gastroenterologist at “Grigore Alexandrescu” Emergency Hospital for Children ๐Ÿฅ, she seamlessly combines patient care with groundbreaking research. Dr. Matran has actively contributed as a subinvestigator for leading pharmaceutical companies, including Takeda Pharmaceuticals (VedolizumabSC-3003) and AbbVie (Adalimumab), advancing therapies for pediatric inflammatory bowel disease ๐Ÿ”ฌ. She also researches post-vaccination adverse reactions as a member of the Advisory Committee at the Ministry of Health, ensuring better health outcomes for children globally ๐Ÿ’‰.

Research Focus

Dr. Roxana Elena Smฤƒdeanu’s research focus primarily revolves around pediatric health, with a special emphasis on diagnosing and managing complex diseases such as cystic fibrosis, intestinal tuberculosis, and respiratory conditions in children. Her work includes exploring microbiota’s role in functional abdominal pain disorders, respiratory symptomatology associated with COVID-19 in pediatric patients, and rare genetic syndromes like Menke-Hennekam syndrome. Additionally, her research delves into diagnostic methods like sweat conductivity in cystic fibrosis. This body of work aligns with clinical and laboratory research aimed at improving pediatric healthcare and diagnostics. ๐Ÿง‘โ€๐Ÿ”ฌ๐Ÿฉบ๐Ÿ‘ถ

Publication Top Notes