Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

Dr.Careen Liza Pakyntein, at NORTH EASTERN HILL UNIVERSITY,India

Author Profile

Skills

  • 🌿 Phytochemical Profiling
  • ⚗️ Gas Chromatography
  • 🧪 Flash Chromatography
  • 🧬 Thin Layer Chromatography
  • 💉 High-Performance Liquid Chromatography (HPTLC)
  • 🧫 Conventional Polymerase Chain Reaction (PCR)
  • 🧬 Real-Time Polymerase Chain Reaction (RT-PCR)
  • ⚡ Electrophoresis Techniques: SDS-PAGE, PFGE
  • 🧬 DNA/RNA/Protein Isolation
  • 🧬 Western Blotting
  • 🧫 Biochemical Analysis
  • 🐭 Mice Handling
  • 🧬 ADME-TOX Profiling
  • 🔬 Immunohistochemistry
  • 🔬 Microscopy
  • 🧫 Microbiology
  • 🧫 Cell Culture

Experience🧑‍🔬

  • Project Scientist-
    • IBSD, Manipur (March 2024 – Present)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Project Associate-I 
    • Division of Animal and Fisheries Sciences, ICAR-RC NEH, Umiam (December 2021 – June 2023)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Research Scholar 
    • Department of Biochemistry, NEHU, Shillong (February 2017 – November 2021)
    • Duties: Drafting research proposals, research data collection, analysis, documentation, interpretation, paper presentation at national and international conferences, paper writing and publication, supervised and mentored PG students for dissertation projects.

Education📚

  •  Ph.D. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2023)
  •  M.Sc. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2016)
  •  B.Sc. in Biochemistry
    • St. Anthony’s College, Shillong (June 2014)
  •  AISSCE (Science)
    • Kendriya Vidyalaya Laitkor Peak, Shillong (May 2011)
  •  SSLC
    • Hill Crest Higher Secondary School, Shillong (May 2009)

Publications 📄

  1. Syiem, A.B., Pakyntein, C.L., Syiem, D., Thabah D. 
    • “Amelioration of carbohydrate and fat metabolism by Houttuynia cordata and Hypochaeris radicata in alloxan-induced diabetic mice.” International Journal of Pharmacological Research (2022); 12(5): e5743.
  2. Sunn, S.E., Syiem, D., Pakyntein, C.L. 
    • “Amelioration of altered adipokines expression and serine/threonine phosphorylation of IRS1 in alloxan-induced diabetes by Potentilla fulgens and its phytochemical constituents.” GSC Biological and Pharmaceutical Sciences (2021); 17(03): 144–152.
  3. Pakyntein, C.L., Syiem, D., Thabah D., Sunn, S.E. 
    • “Antioxidant, anti-inflammatory and antihyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study.” GSC Biological and Pharmaceutical Sciences (2021); 16(03): 145–154.
  4. Saio, V., Syiem, D., Sharma, R., Pakyntein, C.L. 
    • “Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice.” Clinical Phytoscience (2021); 7:6.
  5. Thabah, D., Syiem, D., Pakyntein, C.L., Banerjee, S., Kharshiiing, C.E., Bhattacharjee, A. 
    • “Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study.” Archives of Physiology and Biochemistry (2021); 129(5): 1071-1083.
  6. Wankhar, W., Syiem, D., Pakyntein, C.L., Thabah, D., Sunn S.E. 
    • “Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) – Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.” Behavioural Brain Research (2020); 393: 112780.

 

🎓Publication Top Noted:

Paper Title : Potentilla fulgens Upregulate GLUT4, AMPK, AKT, and Insulin in Alloxan-Induced Diabetic Mice: An In Vivo and In Silico Study 🧬📊
    • Co-Authors: Syiem, D., Pakyntein, C.L., Kharshiing, C.E., Bhattacharjee, A.
    • Journal: Archives of Physiology and Biochemistry
    • Year: 2023
    • Summary: This study investigates the potential of Potentilla fulgens in regulating key metabolic pathways in diabetic mice, highlighting its ability to upregulate important proteins and enzymes involved in glucose metabolism.
  • Paper Title :Effect of 5-HT2C Receptor Agonist and Antagonist on Chronic Unpredictable Stress (CUS) – Mediated Anxiety and Depression in Adolescent Wistar Albino Rat: Implicating Serotonin and Mitochondrial ETC-I Function in Serotonergic Neurotransmission 🧠🔬
    • Co-Authors: Wankhar, W., Syiem, D., Pakyntein, C.L., Sunn, S.E.
    • Journal: Behavioural Brain Research
    • Year: 2020
    • Summary: This research explores the role of 5-HT2C receptors in anxiety and depression caused by chronic unpredictable stress, emphasizing the connection between serotonergic neurotransmission and mitochondrial function.

Dr .Yuan Yao, Drug Discovery and Development ,Best Researcher Award

Dr .Yuan Yao , Drug Discovery and Development ,Best Researcher Award

Dr .Yuan Yao at Peking University Cancer Hospital & Institute,China

Author Profile

🔬 Research and Innovations

Dr. Yao is actively involved in pioneering research, particularly in the field of PET/CT equipment imaging performance. This work is part of the National Key R&D Program, conducted in collaboration with Shandong University and other institutions. Additionally, Dr. Yao has led innovative projects under the Peking University Health Science Center’s “Excellent Doctoral Candidate Innovation Fund.”

📚 Citation Index

As a first author, Dr. Yao has contributed to significant advancements in medical imaging and nuclear medicine through numerous publications:

  • Construction and preclinical evaluation of a zirconium-89 labelled monoclonal antibody targeting PD-L2 in lung cancer (Biomedicine & pharmacotherapy, 2023)
  • Construction and preclinical evaluation of a (124/125)I-Labeled specific antibody targeting PD-L2 in lung cancer (Mol Pharm, 2023)
  • The role of PET molecular imaging in immune checkpoint inhibitor therapy in lung cancer (European Journal of Radiology, 2022)
  • Novel miRNA predicts survival and prognosis of cholangiocarcinoma based on RNA-seq data and in vitro experiments (BioMed Research International, 2020)

🏅 Consultancy and Industry Projects

Dr. Yao has been a key participant in national research projects, including collaborations with Beijing Sino Biological Inc. to develop PD-L2 targeted antibody fragments. This partnership underscores Dr. Yao’s commitment to translating research into practical medical applications.

📖 Editorial Appointments and Professional Memberships

Dr. Yao serves as a reviewer for the International Wound Journal and the Journal of Cancer. Additionally, Dr. Yao is an active member of the Chinese Nuclear Society and the Beijing Precision Radiation Medicine Society.

🏆 Contributions and Impact

Dr. Yao’s groundbreaking work in developing immune checkpoint PD-L2 targeted radiopharmaceuticals has paved the way for new methods to screen potential beneficiaries of immune checkpoint inhibitor therapy. Innovations include monoclonal antibody tracers 124/125I-ATL2 and 89Zr-DFO-ATL2, as well as PD-L2 targeted antibody fragments and polypeptides, contributing significantly to the field of precision medicine.

📜 Patents and Recognitions

Dr. Yao has published three patents with the China National Intellectual Property Administration and has two more in process. Dr. Yao’s dedication to improving clinical practices is evident through the invention of devices that reduce radiation exposure for experimental personnel.

Publication Top Noted:

Paper Title : Elemene injection combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis
  • Authors: Yuan Yao, Jianjian Chen, Dechao Jiao, Yahua Li, Xueliang Zhou, Xinwei Han
  • Journal: Medicine
  • Year: 2019
  • Citations: 11

 

Paper Title : Palliative local treatment of bone metastases by 125I seed brachytherapy under DynaCT guidance: single-center experience
  • Authors:Yuan uan Yao, Zhaonan Li, Dechao Jiao, Xueliang Zhou, Jing Li, Xinwei Han
  • Journal: Diagnostic and Interventional Radiology
  • Year :2021
  • Citations:4
Paper Title : Role of LncRNAs in the epithelial-mesenchymal transition in hepatocellular carcinoma
  • Authors:Yuan Yao, Jing Li, Zhaonan Li, Xinwei Han
  • Journal: Frontiers in oncology
  • Year: 2021
  • Citations: 9
Paper Title :125I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway
  • Authors:   Xueliang Zhou, Wenguang Zhang, Mengmeng Dou, Zhaonan Li, Zaoqu Liu, Jing Li, Chuan Tian, Yuan Yao, Chaoyan Wang, Yahua Li, Pengfei Chen, Xinwei Han, Dechao Jiao
  • Journal: Cancer Letters
  • Year: 2022
  • Citations: 12
Paper Title :Intraoperative cone beam computed tomography of tracheal stenting for stenosis and fistula diseases: a retrospective cohort study
  • Authors: Jing Li, Kaihao Xu, Zhaonan Li, Yahua Li, Xueliang Zhou, Juanfang Liu, Yuan Yao, Zaoqu Liu, De-Chao Jiao, Xinwei Han
  • Journal: Quantitative Imaging in Medicine and Surgery
  • Year: 2022
  • Citations: 2