Assist. Prof. Dr. Basharat Ali | Drug Discovery and Development | Pakistan

University of Baltistan | Pakistan

Assist. Prof. Dr. Basharat Ali is a distinguished researcher and academician specializing in medicinal chemistry, heterocyclic synthesis, and polymer science with extensive expertise in designing and synthesizing biologically active compounds. Currently serving as an Assistant Professor in the Department of Chemistry at the University of Baltistan, Skardu, Pakistan, he has a diverse academic and research background, including postdoctoral research at the College of Pharmaceutical Science, Soochow University, China, where he contributed to the development of chemiluminescent dioxetane probes for disease diagnosis, fluorescent probes for hydrogen sulfide detection, and anthraquinone derivatives as anti-infective agents. He has also worked as a research assistant at Zhejiang University, China, focusing on mechanistic studies of olefin polymerization using α-Diimine nickel(II) catalysts, and at the HEJ Research Institute of Chemistry, University of Karachi, where he specialized in synthetic organic chemistry and bioactive heterocycles.Dr. Basharat Ali’s research interests include the synthesis, structural modification, and biological evaluation of medicinally important synthetic derivatives, probe design for environmental and biomedical applications, multicomponent reactions, polymer synthesis, and catalytic system development. He has supervised numerous postgraduate students and contributed extensively to the field with multiple high-impact publications in reputable international journals. Some of his significant research publications include Synthesis and biological evaluations of 1,3,4-thiadiazole derivatives as dual acting enzyme inhibitors to target inflammation and diabetes, Carbothioamides as anticancer agents: synthesis, in-vitro activity, structure-activity relationship evaluations and molecular docking, Synthesis of (E)-3-(aryl)-1-phenylprop-2-en-1-one Chalcone Derivatives for Hyperglycemic Effect in Diabetes.

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Featured Publications

Li, S., Zhan, L., Zhao, W., Zhang, S., Ali, B., Fu, Z., Lau, T. K., Lu, X., Shi, M., Li, C. Z., … (2018). Revealing the effects of molecular packing on the performances of polymer solar cells based on A–D–C–D–A type non-fullerene acceptors. Journal of Materials Chemistry A, 6(25), 12132–12141.

Ali, F., Khan, K. M., Salar, U., Iqbal, S., Taha, M., Ismail, N. H., Perveen, S., … (2016). Dihydropyrimidones: As novel class of β-glucuronidase inhibitors. Bioorganic & Medicinal Chemistry, 24(16), 3624–3635.

Abbas, A., Ali, B., Khan, K. M., Iqbal, J., Rahman, S. U., Zaib, S., Perveen, S. (2019). Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies. Bioorganic Chemistry, 82, 163–177.

Ali, B., Khan, K. M., Hussain, S., Hussain, S., Ashraf, M., Riaz, M., Wadood, A., … (2018). Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies. Bioorganic Chemistry, 79, 34–45.

Naz, F., Latif, M., Salar, U., Khan, K. M., Al-Rashida, M., Ali, I., Ali, B., Taha, M., … (2020). 4-Oxycoumarinyl linked acetohydrazide Schiff bases as potent urease inhibitors. Bioorganic Chemistry, 105, 104365.

Salar, U., Khan, K. M., Taha, M., Ismail, N. H., Ali, B., Perveen, S., Ghufran, M., … (2017). Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl aryl carboxylate derivatives. European Journal of Medicinal Chemistry, 125, 1289–1299.

Ali, M., Khan, K. M., Salar, U., Ashraf, M., Taha, M., Wadood, A., Hamid, S., Riaz, M., … (2018). Synthesis, in vitro α-glucosidase inhibitory activity, and in silico study of (E)-thiosemicarbazones and (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives. Molecular Diversity, 22(4), 841–861.