Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

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Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

Dr.Careen Liza Pakyntein, at NORTH EASTERN HILL UNIVERSITY,India

Author Profile

Skills⚡

  • 🌿 Phytochemical Profiling
  • ⚗️ Gas Chromatography
  • 🧪 Flash Chromatography
  • 🧬 Thin Layer Chromatography
  • 💉 High-Performance Liquid Chromatography (HPTLC)
  • 🧫 Conventional Polymerase Chain Reaction (PCR)
  • 🧬 Real-Time Polymerase Chain Reaction (RT-PCR)
  • ⚡ Electrophoresis Techniques: SDS-PAGE, PFGE
  • 🧬 DNA/RNA/Protein Isolation
  • 🧬 Western Blotting
  • 🧫 Biochemical Analysis
  • 🐭 Mice Handling
  • 🧬 ADME-TOX Profiling
  • 🔬 Immunohistochemistry
  • 🔬 Microscopy
  • 🧫 Microbiology
  • 🧫 Cell Culture

Experience🧑‍🔬

  • Project Scientist-
    • IBSD, Manipur (March 2024 – Present)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Project Associate-I 
    • Division of Animal and Fisheries Sciences, ICAR-RC NEH, Umiam (December 2021 – June 2023)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Research Scholar 
    • Department of Biochemistry, NEHU, Shillong (February 2017 – November 2021)
    • Duties: Drafting research proposals, research data collection, analysis, documentation, interpretation, paper presentation at national and international conferences, paper writing and publication, supervised and mentored PG students for dissertation projects.

Education📚

  •  Ph.D. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2023)
  •  M.Sc. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2016)
  •  B.Sc. in Biochemistry
    • St. Anthony’s College, Shillong (June 2014)
  •  AISSCE (Science)
    • Kendriya Vidyalaya Laitkor Peak, Shillong (May 2011)
  •  SSLC
    • Hill Crest Higher Secondary School, Shillong (May 2009)

Publications 📄

  1. Syiem, A.B., Pakyntein, C.L., Syiem, D., Thabah D. 
    • “Amelioration of carbohydrate and fat metabolism by Houttuynia cordata and Hypochaeris radicata in alloxan-induced diabetic mice.” International Journal of Pharmacological Research (2022); 12(5): e5743.
  2. Sunn, S.E., Syiem, D., Pakyntein, C.L. 
    • “Amelioration of altered adipokines expression and serine/threonine phosphorylation of IRS1 in alloxan-induced diabetes by Potentilla fulgens and its phytochemical constituents.” GSC Biological and Pharmaceutical Sciences (2021); 17(03): 144–152.
  3. Pakyntein, C.L., Syiem, D., Thabah D., Sunn, S.E. 
    • “Antioxidant, anti-inflammatory and antihyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study.” GSC Biological and Pharmaceutical Sciences (2021); 16(03): 145–154.
  4. Saio, V., Syiem, D., Sharma, R., Pakyntein, C.L. 
    • “Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice.” Clinical Phytoscience (2021); 7:6.
  5. Thabah, D., Syiem, D., Pakyntein, C.L., Banerjee, S., Kharshiiing, C.E., Bhattacharjee, A. 
    • “Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study.” Archives of Physiology and Biochemistry (2021); 129(5): 1071-1083.
  6. Wankhar, W., Syiem, D., Pakyntein, C.L., Thabah, D., Sunn S.E. 
    • “Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) – Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.” Behavioural Brain Research (2020); 393: 112780.

 

🎓Publication Top Noted:

Paper Title : Potentilla fulgens Upregulate GLUT4, AMPK, AKT, and Insulin in Alloxan-Induced Diabetic Mice: An In Vivo and In Silico Study 🧬📊
    • Co-Authors: Syiem, D., Pakyntein, C.L., Kharshiing, C.E., Bhattacharjee, A.
    • Journal: Archives of Physiology and Biochemistry
    • Year: 2023
    • Summary: This study investigates the potential of Potentilla fulgens in regulating key metabolic pathways in diabetic mice, highlighting its ability to upregulate important proteins and enzymes involved in glucose metabolism.
  • Paper Title :Effect of 5-HT2C Receptor Agonist and Antagonist on Chronic Unpredictable Stress (CUS) – Mediated Anxiety and Depression in Adolescent Wistar Albino Rat: Implicating Serotonin and Mitochondrial ETC-I Function in Serotonergic Neurotransmission 🧠🔬
    • Co-Authors: Wankhar, W., Syiem, D., Pakyntein, C.L., Sunn, S.E.
    • Journal: Behavioural Brain Research
    • Year: 2020
    • Summary: This research explores the role of 5-HT2C receptors in anxiety and depression caused by chronic unpredictable stress, emphasizing the connection between serotonergic neurotransmission and mitochondrial function.

Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

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Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

Dr. JOHANN LECHNER atPraxisklinik Integrative ZahnMedizin,Germany

Author Profile

 

🔬 Innovator in Jawbone Health

Dr. Lechner’s research emphasizes the significance of unresolved wound healing in the jawbone, particularly after procedures like wisdom tooth extractions. He has identified that these unhealed areas often fill with fatty degenerative osteonecrosis (FDOJ), leading to silent, chronic inflammation.

🧬 Linking FDOJ with Systemic Diseases

Dr. Lechner’s pioneering idea connects the overexpression of the chemokine RANTES/CCL5 in FDOJ to systemic inflammation, contributing to diseases such as cancer and autoimmune conditions. His work highlights the importance of recognizing and addressing these hidden jawbone infections to improve overall health outcomes.

📈 Advancements in Diagnostic Techniques

Traditional imaging methods like x-rays and CBCT/DTV often fail to detect FDOJs. Dr. Lechner’s research led to the development and validation of trans alveolar ultrasound sonography (TAU), a technique that accurately measures jawbone density and identifies FDOJs. This breakthrough has been documented in studies published in Ultrasound in Medicine and Biology.

Impact on Patient Health
Dr. Lechner’s findings reveal that removing these silent jawbone inflammations can significantly enhance the body’s healing capabilities, transforming the lives of patients suffering from chronic inflammatory conditions. His work has the potential to revolutionize dental practice and systemic disease management, offering hope to millions.

Vision for the Future
Dr. Lechner envisions a future where every dentist has the tools to diagnose and treat FDOJs, drastically reducing the prevalence of systemic diseases linked to chronic inflammation. His research and clinical practices continue to inspire the medical and dental communities to integrate Jawbone Detox into standard healthcare protocols, promoting a holistic approach to health and wellness.

Publication Top Noted:

Osteoimmune Interaction and TH-1/TH-2 Ratio in Jawbone Marrow Defects: An Underestimated Association – Original Research

Comparison of Cytokine RANTES/CCL5 Inflammation in Apical Periodontitis and in Jawbone Cavitations – Retrospective Clinical Study

Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics: research and case reports

 Reduction of Inflammatory RANTES/CCLS Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone

Linking Dentistry and Chronic Inflammatory Autoimmune Diseases – Can Oral and Jawbone Stressors Affect Systemic Symptoms of Atopic Dermatitis? A Case Report

 

 

Dr. Caesar Hernandez, Nanomedicine ,Best Researcher Award

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Dr. Caesar Hernandez, Nanomedicine ,Best Researcher Award

Dr. Caesar Hernandez at The University of Alabama at Birmingham,United States Korea

Author Profile

🎓 Education

  • 2018: PhD in Medical Sciences, Concentration in Neuroscience, University of Florida
    • Thesis: “Circuit and Molecular Mechanisms of Altered Decision Making in Aging” (Advisors: Dr. Jennifer Lynn Bizon and Dr. Barry Setlow)
  • 2014: MS in Biological Sciences, Florida Atlantic University
    • Thesis: “Methionine Reductase Sulfoxide (Msr) Deficiency Leads to a Reduction of Dopamine Levels in Drosophila” (Advisors: Dr. David Binninger and Dr. Herbert Weissbach)
  • 2011: BS in Biological Sciences with a Minor in Biotechnology, Magna Cum Laude, Florida Atlantic University
  • 2009: AA in Biology, Palm Beach State College

🏫 Professional and Research Experience

  • 2023-Present: Assistant Professor, Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham
  • 2022-2023: Postdoctoral Fellow, Laboratories of Dr. Lynn Dobrunz, Dr. Peter King, and Dr. Lori McMahon, Department of Neurobiology, University of Alabama at Birmingham
  • 2020-2022: Postdoctoral Fellow, Laboratory of Dr. Lori McMahon, Department of Cellular, Developmental, and Integrative Biology, University of Alabama at Birmingham
  • 2019-2020: Postdoctoral Associate, Laboratories of Dr. Barry Setlow and Dr. Jennifer L. Bizon, Departments of Psychiatry and Neuroscience, University of Florida
  • 2014-2018: Graduate Research Assistant, Laboratories of Dr. Jennifer L. Bizon and Dr. Barry Setlow, Departments of Neuroscience and Psychiatry, University of Florida
  • 2012-2014: Graduate Research Assistant, Laboratory of Dr. David Binninger, Department of Biological Sciences, Florida Atlantic University
  • 2012-2014: Lab Manager, Laboratory of Dr. Herbert Weissbach, Center for Molecular Biology and Biotechnology, Florida Atlantic University

🏅 Research Grants and Fellowships

  • NIH Pathway to Independence Award (Parent K99/R00): Research on the impact of normative aging and Alzheimer’s disease on fear-based disorders and amygdala dysfunction
  • NIH T32 Interdisciplinary Training in Pathobiology and Rehabilitation Medicine
  • McKnight Predoctoral Fellowship, Florida Education Fund
  • Tillman Military Scholarship, Pat Tillman Foundation
  • Honorably Discharged Graduate Assistant Scholarship, University of Florida

🌟 Academic and Professional Awards

  • 1st Place Presentation for Postdoctoral Research Day, UAB’s Postdoctoral Office of Education (2022, 2021)
  • 3rd Place Award for Trainee Talk Session, Comprehensive Neuroscience Center Retreat (2022)
  • Neuroscience Scholars Program Enrichment Fund, Society for Neuroscience (2020, 2019)
  • Silver Award, College of Medicine Medical Guild Graduate Research Competition (2018)
  • Cluff Award for Aging Research, Leighton E. Cluff Endowment and The Institute for Learning in Retirement at Oak Hammock (2018)
  • William G. Luttge Award for Outstanding Graduate Research in Neuroscience (2018)
  • Travel Awards, McKnight Brain Institute and International Behavioral Neuroscience Society (2018)

🎓Publication Top Noted:

Paper Title : A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus
  • Authors: Abbi R Hernandez, Caesar M Hernandez, Keila Campos, Leah Truckenbrod, Quinten Federico, Brianna Moon, Joseph A McQuail, Andrew P Maurer, Jennifer L Bizon, Sara N Burke
  • Journal: Frontiers in aging neuroscience
  • Year:2018

 

Paper Title : Optogenetic inhibition reveals distinct roles for basolateral amygdala activity at discrete time points during risky decision making
  • Authors: Caitlin A Orsini, Caesar M Hernandez, Sarthak Singhal, Kyle B Kelly, Charles J Frazier, Jennifer L Bizon, Barry Setlow
  • Journal:Journal of Neuroscience
  • Year: 2017
Paper Title :Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models
  • Authors:Caitlin A Orsini, Caesar M Hernandez, Jennifer L Bizon, Barry Setlow
  • Journal: Cognitive, Affective, & Behavioral Neuroscience
  • Year: 2019
Paper Title :Testicular hormones mediate robust sex differences in impulsive choice in rats
  • Authors:Caesar M Hernandez, Caitlin Orsini, Alexa-Rae Wheeler, Tyler W Ten Eyck, Sara M Betzhold, Chase C Labiste, Noelle G Wright, Barry Setlow, Jennifer L Bizon
  • Journal: eLife Sciences Publications, Ltd
  • Year: 2020
Paper Title :A neuroscience primer for integrating geroscience with the neurobiology of aging
  • Authors:  JCaesar M Hernandez, Abigail R Hernandez, Jessica M Hoffman, Peter H King, Lori L McMahon, Thomas W Buford, Christy Carter, Jennifer L Bizon, Sara N Burke
  • Journal: The Journals of Gerontology: Series A
  • Year: 2022