Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

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Dr.Careen Liza Pakyntein, Pharmaceutical Analysis ,Best Researcher Award

Dr.Careen Liza Pakyntein, at NORTH EASTERN HILL UNIVERSITY,India

Author Profile

Skills⚡

  • 🌿 Phytochemical Profiling
  • ⚗️ Gas Chromatography
  • 🧪 Flash Chromatography
  • 🧬 Thin Layer Chromatography
  • 💉 High-Performance Liquid Chromatography (HPTLC)
  • 🧫 Conventional Polymerase Chain Reaction (PCR)
  • 🧬 Real-Time Polymerase Chain Reaction (RT-PCR)
  • ⚡ Electrophoresis Techniques: SDS-PAGE, PFGE
  • 🧬 DNA/RNA/Protein Isolation
  • 🧬 Western Blotting
  • 🧫 Biochemical Analysis
  • 🐭 Mice Handling
  • 🧬 ADME-TOX Profiling
  • 🔬 Immunohistochemistry
  • 🔬 Microscopy
  • 🧫 Microbiology
  • 🧫 Cell Culture

Experience🧑‍🔬

  • Project Scientist-
    • IBSD, Manipur (March 2024 – Present)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Project Associate-I 
    • Division of Animal and Fisheries Sciences, ICAR-RC NEH, Umiam (December 2021 – June 2023)
    • Duties: Sample screening and analysis, data collection and interpretation, data documentation, preparation of reports, presentations, project deliverables.
  • Research Scholar 
    • Department of Biochemistry, NEHU, Shillong (February 2017 – November 2021)
    • Duties: Drafting research proposals, research data collection, analysis, documentation, interpretation, paper presentation at national and international conferences, paper writing and publication, supervised and mentored PG students for dissertation projects.

Education📚

  •  Ph.D. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2023)
  •  M.Sc. in Biochemistry
    • North-Eastern Hill University, Shillong (August 2016)
  •  B.Sc. in Biochemistry
    • St. Anthony’s College, Shillong (June 2014)
  •  AISSCE (Science)
    • Kendriya Vidyalaya Laitkor Peak, Shillong (May 2011)
  •  SSLC
    • Hill Crest Higher Secondary School, Shillong (May 2009)

Publications 📄

  1. Syiem, A.B., Pakyntein, C.L., Syiem, D., Thabah D. 
    • “Amelioration of carbohydrate and fat metabolism by Houttuynia cordata and Hypochaeris radicata in alloxan-induced diabetic mice.” International Journal of Pharmacological Research (2022); 12(5): e5743.
  2. Sunn, S.E., Syiem, D., Pakyntein, C.L. 
    • “Amelioration of altered adipokines expression and serine/threonine phosphorylation of IRS1 in alloxan-induced diabetes by Potentilla fulgens and its phytochemical constituents.” GSC Biological and Pharmaceutical Sciences (2021); 17(03): 144–152.
  3. Pakyntein, C.L., Syiem, D., Thabah D., Sunn, S.E. 
    • “Antioxidant, anti-inflammatory and antihyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study.” GSC Biological and Pharmaceutical Sciences (2021); 16(03): 145–154.
  4. Saio, V., Syiem, D., Sharma, R., Pakyntein, C.L. 
    • “Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice.” Clinical Phytoscience (2021); 7:6.
  5. Thabah, D., Syiem, D., Pakyntein, C.L., Banerjee, S., Kharshiiing, C.E., Bhattacharjee, A. 
    • “Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study.” Archives of Physiology and Biochemistry (2021); 129(5): 1071-1083.
  6. Wankhar, W., Syiem, D., Pakyntein, C.L., Thabah, D., Sunn S.E. 
    • “Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) – Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.” Behavioural Brain Research (2020); 393: 112780.

 

🎓Publication Top Noted:

Paper Title : Potentilla fulgens Upregulate GLUT4, AMPK, AKT, and Insulin in Alloxan-Induced Diabetic Mice: An In Vivo and In Silico Study 🧬📊
    • Co-Authors: Syiem, D., Pakyntein, C.L., Kharshiing, C.E., Bhattacharjee, A.
    • Journal: Archives of Physiology and Biochemistry
    • Year: 2023
    • Summary: This study investigates the potential of Potentilla fulgens in regulating key metabolic pathways in diabetic mice, highlighting its ability to upregulate important proteins and enzymes involved in glucose metabolism.
  • Paper Title :Effect of 5-HT2C Receptor Agonist and Antagonist on Chronic Unpredictable Stress (CUS) – Mediated Anxiety and Depression in Adolescent Wistar Albino Rat: Implicating Serotonin and Mitochondrial ETC-I Function in Serotonergic Neurotransmission 🧠🔬
    • Co-Authors: Wankhar, W., Syiem, D., Pakyntein, C.L., Sunn, S.E.
    • Journal: Behavioural Brain Research
    • Year: 2020
    • Summary: This research explores the role of 5-HT2C receptors in anxiety and depression caused by chronic unpredictable stress, emphasizing the connection between serotonergic neurotransmission and mitochondrial function.

Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

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Dr. JOHANN LECHNER , Bioinformatics ,Best Researcher Award

Dr. JOHANN LECHNER atPraxisklinik Integrative ZahnMedizin,Germany

Author Profile

 

🔬 Innovator in Jawbone Health

Dr. Lechner’s research emphasizes the significance of unresolved wound healing in the jawbone, particularly after procedures like wisdom tooth extractions. He has identified that these unhealed areas often fill with fatty degenerative osteonecrosis (FDOJ), leading to silent, chronic inflammation.

🧬 Linking FDOJ with Systemic Diseases

Dr. Lechner’s pioneering idea connects the overexpression of the chemokine RANTES/CCL5 in FDOJ to systemic inflammation, contributing to diseases such as cancer and autoimmune conditions. His work highlights the importance of recognizing and addressing these hidden jawbone infections to improve overall health outcomes.

📈 Advancements in Diagnostic Techniques

Traditional imaging methods like x-rays and CBCT/DTV often fail to detect FDOJs. Dr. Lechner’s research led to the development and validation of trans alveolar ultrasound sonography (TAU), a technique that accurately measures jawbone density and identifies FDOJs. This breakthrough has been documented in studies published in Ultrasound in Medicine and Biology.

Impact on Patient Health
Dr. Lechner’s findings reveal that removing these silent jawbone inflammations can significantly enhance the body’s healing capabilities, transforming the lives of patients suffering from chronic inflammatory conditions. His work has the potential to revolutionize dental practice and systemic disease management, offering hope to millions.

Vision for the Future
Dr. Lechner envisions a future where every dentist has the tools to diagnose and treat FDOJs, drastically reducing the prevalence of systemic diseases linked to chronic inflammation. His research and clinical practices continue to inspire the medical and dental communities to integrate Jawbone Detox into standard healthcare protocols, promoting a holistic approach to health and wellness.

Publication Top Noted:

Osteoimmune Interaction and TH-1/TH-2 Ratio in Jawbone Marrow Defects: An Underestimated Association – Original Research

Comparison of Cytokine RANTES/CCL5 Inflammation in Apical Periodontitis and in Jawbone Cavitations – Retrospective Clinical Study

Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics: research and case reports

 Reduction of Inflammatory RANTES/CCLS Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone

Linking Dentistry and Chronic Inflammatory Autoimmune Diseases – Can Oral and Jawbone Stressors Affect Systemic Symptoms of Atopic Dermatitis? A Case Report

 

 

Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award-duplicate

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Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award

Assoc Prof Dr .Xing-Xing Fan at Macau University of Science and Technology,China

Author Profile

🎓 Academic Qualifications:

  1. Ph.D., Chinese Medicines, Macau University of Science and Technology, Macau, 2014
  2. M.Sc., Pathogenesis, Tianjin Medical University, China, 2010
  3. M.D., Clinical Medicine, Tianjin Medical University, China, 2007

🔬 Research Interests:

  1. Development of small molecule targeted drugs.
  2. CAR-T cell therapy for lung cancer.
  3. Nanobodies generation for restoring T cell anti-tumor activity.

📅 Professional Chronology:

  1. Associate Professor, Macau University of Science and Technology, July 2023 – Present
  2. Assistant Professor, Macau University of Science and Technology, September 2017 – June 2023
  3. Postdoctoral Fellow, Macau University of Science and Technology, September 2014 – September 2017

📚 Academic Institutions and Social Work:

  1. Standing Director:
    1. Executive Director of the Professional Committee of Immunology of Traditional Chinese Medicine of the World Federation of Chinese Medicine Societies
    2. Executive Director of the Council of Macao International Cooperation Alliance for Rheumatology Research
  2. Membership:
    1. American Association for Cancer Research
    2. The Consortium for Globalization of Chinese Medicine
  3. Editor or Board Member of SCI Journals:
    1. Associate Editor of Heliyon
    2. Guest Editor of Pharmacological Research, Oxidative Medicine and Cellular Longevity, and Frontiers in Pharmacology

📖 Representative Publications within 5 Years:

  1. Li R#, Fan X#, Jiang Z, Huang J, Gavine P, Fehlings M, Nardin A, Liu L, Cao Y, Leung E. Longitudinal high-dimensional analysis identifies biomarkers of response to anti-PD-1 immunotherapy. Nature Communications. Just accepted. IF=17.694.
  2. Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang & Xing-Xing Fan*. Tumor PKCδ instigates immune exclusion in EGFR-mutated non– small cell lung cancer. BMC Medicine. volume 20, Article number: 470 (2022). IF=11.806.
  3. Elaine Lai-Han Leung#, Xing-Xing Fan#, Ju-Min Huang, Chen Huang, Hong Lin, Ya- Bing Cao. Holistic immunomodulation for small cell lung cancer. Seminars in Cancer Biology. 2022 Dec 2; S1044-579X (22)00245-0. IF= 17.012.
  4. Ying Xie, Sen-Ling Feng, Fang He, Pei-Yu Yan, Xiao-Jun Yao, Xing-Xing Fan*, Elaine Lai-Han Leung, Hua Zhou. Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer. Pharmacological Research. 2022 Dec;186:106514. IF= 10.330.
  5. YJ Xie, M Huang, D Li, JC Hou, HH Liang, AA Nasim, JM Huang, C Xie, Xing-xing Fan*. Bacteria-based nanodrug for anticancer therapy. Pharmacological Research, 106282. IF= 10.330.
  6. Min Huang, Fang He, Dan Li, Ya-Jia Xie, Elaine Lai-Han Leung, Xing-Xing Fan*. PA- MSHA Induces Inflamed Tumor Microenvironment and Sensitizes Tumor to Anti-PD-1 Therapy, Cell Death & Disease. 2022 Nov 7;13(11):931. IF= 9.685.

🎓Publication Top Noted:

Paper Title : SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma
  • Authors:Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing Hee
  • Journal: Oncotarget
  • Year:2016
  • Citations : 86

 

Paper Title : Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
  • Authors: Xia Li, Xing-Xing Fan, Ze-Bo Jiang, Wings TY Loo, Xiao-Jun Yao, Elaine Lai-Han Leung, Louis WC Chow, Liang Liu
  • Journal: Pharmacological Research
  • Year: 2017
  • Citations : 85
Paper Title :Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis
  • Authors: Guihua Tian, Chuanhong Wu, Jian Li, Bilin Liang, Feilong Zhang, Xingxing Fan, Zewei Li, Yongjun Wang, Zhihong Li, Di Liu, Elaine Lai-Han Leung, Jianxin Chen
  • Journal:Pharmacological research
  • Year: 2019
  • Citations : 77
Paper Title :ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria
  • Authors:Xing-xing Fan, Meng-ze Xu, Elaine Lai-Han Leung, Cai Jun, Zhen Yuan, Liang Liu
  • Journal: Nano-micro letters
  • Year:2020
  • Citations : 81
Paper Title :Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer
  • Authors:  JZe-Bo Jiang, Wen-Jun Wang, Cong Xu, Ya-Jia Xie, Xuan-Run Wang, Yi-Zhong Zhang, Ju-Min Huang, Min Huang, Chun Xie, Pei Liu, Xing-Xing Fan, Yu-Po Ma, Pei-Yu Yan, Liang Liu, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
  • Journal: Cancer letters
  • Year: 2021
  • Citations :113