juan iovanna | Personalized Medicine | Best Researcher Award

juan iovanna | Personalized Medicine | Best Researcher Award

Prof. Dr. juan iovanna, INSERM, France

Prof. Dr. Juan Iovanna è un medico e ricercatore internazionale esperto in oncologia, specializzato nello studio del carcinoma pancreatico. Laureato e dottorato all’Università di Buenos Aires, lavora in Francia dal 1991 presso l’INSERM, dove ha raggiunto il grado di Direttore di Ricerca di Classe Eccezionale. Co-dirige il gruppo “Biologia del cancro pancreatico” al CRCM di Marsiglia e presiede il Programma G7 Cancer. Fondatore di tre start-up biotecnologiche, ha pubblicato 472 articoli con oltre 43.500 citazioni 📚. La sua missione è migliorare la prognosi del tumore pancreatico attraverso ricerca e innovazione terapeutica.

Publication Profile

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Education

Prof. Dr. Juan Iovanna began his academic journey with a degree in Medicine from the University of Buenos Aires, Argentina, in 1982. Driven by a passion for biomedical research, he pursued a Ph.D. in Biomedical Sciences at the same university, which he completed in 1986. 🧬 His doctoral thesis, titled “Meccanismi di regolazione della sintesi proteica in modelli cellulari di stress,” focused on the mechanisms regulating protein synthesis in cellular stress models. 🧪 This foundational work laid the groundwork for his future contributions to medical science and molecular biology.

Experience

🔬 Prof. Dr. Juan Iovanna has built an illustrious career in cancer research. In 1991, he began as a researcher at INSERM in France and was promoted to Research Director in 1993 and again in 1998. 🚀 In 2011, he achieved the prestigious title of Directeur de Recherche de Classe Exceptionnelle (DRCE). From 2011 to 2023, he served as Vice-Director of the Marseille Cancer Research Center (CRCM) and led its Translational Medicine Department. 🧫 He also directed the “Pancreatic Cancer Biology” group from 1999 to 2023. Since 2024, he co-directs this group with Dr. Nelson Dusetti and serves as Emeritus Research Director.

Distinctions and Awards

Prof. Dr. Juan Iovanna has received numerous prestigious awards and honors throughout his career. In 2017, he was awarded the Jean Valade Prize by the Fondation de France for his outstanding contributions to biomedical research. 🌍 In 2018, he received the RAICES Award from Argentina’s Ministry of Science, Technology, and Innovation. 🇫🇷 In 2021, the French Senate honored him with a commemorative medal. In 2023, he was named Honorary Professor at the National University Arturo Jauretche (UNAJ), and in 2024, he was recognized as a Distinguished and Honorary Member of the University of Buenos Aires.

Research Focus

Prof. Dr. Juan Iovanna’s research is centered on precision oncology, with a primary focus on pancreatic ductal adenocarcinoma (PDAC). His work integrates transcriptomics, drug resistance mechanisms, redox metabolism, and multi-omics modeling to uncover novel therapeutic vulnerabilities and biomarkers. He contributes to the development of RNA signatures (like GemPred) to predict chemotherapy response, and investigates KRAS inhibition and therapy-induced senescence as pathways to reverse drug resistance. His translational studies aim to optimize personalized treatment strategies for pancreatic cancer patients, bridging molecular insights with clinical application.

Publication Top Notes

KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

The PancreasView gemcitabine transcriptomic signature predicts response to gemcitabine in patients with resected pancreatic ductal adenocarcinoma

Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer

Reply to the Letter to the Editor regarding ‘Chi-squared and P-values vs. machine learning feature selection by Y. Takefuji’

Reply to the Letter to the Editor ‘AI-assisted personalized adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma’ by Y. Shimazu

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial
Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity
Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool

Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction

Mrs. Ana Catarina Sousa| Personalized Medicine|Best Researcher Award

Mrs. Ana Catarina Sousa| Personalized Medicine|Best Researcher Award

Mrs. Ana Catarina Sousa at School of Medicine and Biomedical Sciences – University of Porto (ICBAS),Portugal

PROFILE  

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Early Academic Pursuits 🎓

Ana Catarina Soares de Sousa’s academic journey is marked by a strong focus on the intersection of healthcare and engineering. She completed her Master’s degree in Health Services Management and Economics in 2021 at the prestigious University of Porto, one of the top academic institutions in Portugal. This degree provided her with in-depth knowledge of the economic and managerial aspects of healthcare services, a vital skill set for navigating the complexities of healthcare systems and improving service delivery.

Prior to this, she earned a Master’s degree in Integrated Master in Bioengineering in 2018 at the same university. This program combined principles of biology, medicine, and engineering, equipping her with a solid foundation in biomedical engineering—particularly crucial for her subsequent research on biomaterials and medical technologies. Her dual educational background uniquely positions her to address both the technical and systemic challenges in health services, a hallmark of her later work.

Since 2020, Ana Catarina has been pursuing a PhD in Biomedical Sciences at the Abel Salazar Institute of Biomedical Sciences (ICBAS) within the University of Porto. Her PhD program focuses on interdisciplinary research in medical and health sciences, allowing her to build on her expertise in biomaterials and tissue engineering, while contributing to innovations in medical biotechnology.

Professional Endeavors 💼

Ana Catarina’s professional journey reflects a commitment to both research and practical applications in the biomedical sciences. Throughout her career, she has participated in numerous research projects, taking on key roles both as a research fellow and a lead researcher. Since 2018, she has contributed to seven major research projects, focusing on cutting-edge biomedical technologies and solutions for healthcare challenges.

Among her significant projects are:

  • InnovaBIOMAS (2023–2026): An innovative biofabrication system for creating multi-tissue scaffolds for joint disease treatments. This project highlights her expertise in biomaterials and tissue engineering.
  • H2Cure (2021–2024): A project developing novel formulations, including honey-based gels and dressings with gelan gum and hyaluronic acid for wound care—an intersection of regenerative medicine and biotechnology.
  • PRECOGFIL (2020–2024): This initiative explores the development of pre-tensioned cog threads for transvaginal repair of compartment prolapse, showing her application of bioengineering in women’s health.
  • Bone2Move (2018–2021): Focused on 4D scaffolds for bone defect repair, it underscores her involvement in the evolution of tissue engineering techniques.

Her work has crossed the boundaries of disciplines, spanning medical technology, veterinary applications, regenerative medicine, and materials engineering.

Contributions and Research Focus 🔬

Ana Catarina’s contributions to the biomedical field have been prolific. With 30 peer-reviewed journal articles and 2 book chapters, she has established herself as a thought leader in the scientific community. Her research encompasses a range of fields, but she is particularly recognized for her work in Medical Biotechnology, with a specific emphasis on biomaterials and tissue engineering.

Some of the key areas of her research include:

  • Regenerative Medicine: Her focus on developing advanced biomaterials that can aid in tissue regeneration and healing has practical applications in orthopedics, wound care, and surgical interventions.
  • Veterinary Medicine: Her interdisciplinary approach extends into veterinary science, where she applies biomedical engineering techniques to animal health.
  • Translational Medicine: Ana Catarina is committed to bridging the gap between laboratory research and clinical applications, ensuring that her discoveries can have a real-world impact on patient care.
  • Sustainable Chemistry: She has also been involved in developing environmentally friendly materials and chemical processes for healthcare applications, contributing to sustainability in medical technology.
  • Chemistry for Health: Her work in this area includes the development of biomaterials and formulations aimed at improving health outcomes through innovative chemistry.

With 214 co-authors in her published works, she has demonstrated an impressive ability to collaborate across disciplines and with researchers from around the world.

Accolades and Recognition 🏆

Ana Catarina’s work has not gone unnoticed. She has been the recipient of one award that recognizes her contributions to the field of biomedical sciences. This accolade highlights her innovative approach to healthcare challenges and her ability to bring together diverse disciplines in pursuit of improved health outcomes.

In addition to her award, she has also been instrumental in the scientific community as an event organizer. She has successfully organized three major events, bringing together researchers, healthcare professionals, and industry experts to discuss the latest advancements in biomedical sciences and medical technologies.

Impact and Influence 🌍

Ana Catarina’s work in biomedical sciences has the potential to make a far-reaching impact on both human and animal health. By focusing on innovative biomaterials and medical biotechnology, she is contributing to the development of new treatments that could transform the way diseases are managed and treated. Her research on scaffold-based tissue regeneration and wound care formulations has implications for patients suffering from joint diseases, chronic wounds, and surgical complications.

Her work in the development of advanced biofabrication systems and pre-tensioned threads for surgical repairs also promises to improve surgical outcomes and post-surgical recovery for patients. Moreover, her focus on sustainable chemical processes ensures that her contributions are not only medically valuable but also environmentally responsible.

Legacy and Future Contributions 🌟

Looking ahead, Ana Catarina is poised to continue making groundbreaking contributions to the field of biomedical sciences. Her ongoing projects, particularly those related to biomaterials for regenerative medicine, have the potential to lead to new therapies that will benefit both human and veterinary medicine.

Her focus on translational research ensures that her work will continue to have a direct impact on clinical practices, making her a key figure in the future of medical biotechnology. As she progresses in her PhD journey and beyond, Ana Catarina Soares de Sousa is likely to leave a lasting legacy in the fields of tissue engineering and healthcare innovation.

In the years to come, her work is expected to influence not only scientific research but also the development of new medical technologies that will improve patient care and healthcare systems around the world.

🎓Publication 

Peripheral nerve injury treatments and advances: one health perspective

  • Authors   :Bruna Lopes, Patrícia Sousa, Rui Alvites, Mariana Branquinho, Ana Catarina Sousa, Carla Mendonça, Luís Miguel Atayde, Ana Lúcia Luís, Artur SP Varejão, Ana Colette Maurício
  • Journal    :International journal of molecular sciences
  • Year         :2022

Dental pulp stem cells and Bonelike® for bone regeneration in ovine model

  • Authors   : JM Campos, AC Sousa, AR Caseiro, SS Pedrosa, PO Pinto, MV Branqu
  • Journal    :Regenerative biomaterials
  • Year         :2019

Mesenchymal stem/stromal cells and their paracrine activity—immunomodulation mechanisms and how to influence the therapeutic potential

  • Authors   : Rui Alvites, Mariana Branquinho, Ana C Sousa, Bruna Lopes, Patrícia Sousa, Ana Colette Maurício
  • Journal    :Pharmaceutics
  • Year         :2022

Assessment of the environmental impacts of medical devices: a review

  • Authors   :Ana Catarina Sousa, Anabela Veiga, Ana Collete Maurício, Maria Ascensão Lopes, José Domingos Santos, Belmira Neto
  • Journal    :Environment, Development and Sustainability
  • Year         :2021

Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo

  • Authors   :Rui D Alvites, Mariana V Branquinho, Ana C Sousa, Irina Amorim, Rui Magalhães, Filipa João, Diogo Almeida, Sandra Amado, Justina Prada, Isabel Pires, Federica Zen, Stefania Raimondo, Ana L Luís, Stefano Geuna, Artur SP Varejão, Ana C Maurício
  • Journal    :Stem cells international
  • Year         :2021