Dr.Jaroslav Mráz, Pharmacokinetics ,Excellence in Innovation

Dr.Jaroslav Mráz, at National Institute of Public Health,Czech Republic

Author Profile

Education 📚

  • Undergraduate Studies (1978-83): Department of Analytical Chemistry, Faculty of Natural Sciences, Charles University, Prague, Czech Republic.
  • PhD Studies (1987-92): Department of Analytical Chemistry, Faculty of Natural Sciences, Charles University, Prague. Thesis: “New Analytical Procedures in the Metabolism Studies of Selected Toxic Compounds.”

Professional Experience 🏢

  • National Institute of Public Health, Prague (1983-2024):
    • Centre of Occupational Health, Department for the Assessment of Occupational Exposure to Chemicals.
    • Current Position: Head of the Department.

Foreign Fellowships 🌍

  • Aston University, Birmingham, UK (1991-92): Supported by the European Science Foundation, Fellowships in Toxicology (12 months).
  • Occupational Poisoning Centre, Tokyo Rosai Hospital, Japan (2002): 1-month fellowship.

Research Activities 🔬

  • Metabolism studies on industrially important organic compounds.
  • Chemical toxicology.
  • Development of analytical procedures for the determination of organic compounds in biological materials.
  • Identification and validation of new biomarkers of exposure to chemicals.
  • Human biomonitoring.
  • Specific Field of Interest: Formation and biological fate of the adducts of reactive xenobiotics with blood proteins and their use in human biomonitoring.

Publication Activities 📖

  • Original Full Papers with Impact Factor: 50
  • Citations: 1120
  • h-index: 18

🎓Publication Top Noted:

Paper Title : New Aminobiphenylcysteine Derivatives in Globin and Urine of Rats Dosed with 4-Aminobiphenyl, a Tobacco Smoke Carcinogen
  • Authors:Řimnáčová L., Moos M., Opekar S., Vodrážka P., Pejchal V., Mráz J., Šimek P.
  • Journal: Journal of Analytical Toxicology
  • Volume: 47
  • Issue: 1
  • Pages: 43–51
  • Year: 2023
Paper Title :HEALTH EFFECTS OF EXPOSURE TO ISOCYANATES IN A CAR FACTORY
    • Authors: Řimnáčová L., Moos M., Opekar S., Vodrážka P., Pejchal V., Mráz J., Šimek P.
    • Journal: Central European Journal of Public Health
    • Volume: 30
    • Issue: 1
    • Pages: 32–36
    • Year: 2022
Paper Title :Syntheses of methylcarbamoylated amino acids using synthetic equivalents of methyl isocyanate
  • Authors:Řimnáčová L., Moos M., Opekar S., Vodrážka P., Pejchal V., Mráz J., Šimek P.
  • Journal: Synthetic Communications
  • Volume: 52
  • Issue: 4
  • Pages: 622–628
  • Year: 2022
Paper Title :Ethyl chloroformate mediated gas chromatographic-mass spectrometric biomonitoring of acidic biomarkers of occupational exposure and endogenous metabolites in human urine
  • Authors: Řimnáčová L., Moos M., Opekar S., Vodrážka P., Pejchal V., Mráz J., Šimek P.
  • Journal: Malaysian Applied Biology
  • Year: 2023
  • Citations :1
Paper Title :HPLC–ESI–HRMS2 Determination of N-(2-Hydroxyethyl)-L-valyl-L-leucine in Human Urine: Method Validation
  • Authors: Řimnáčová L., Moos M., Opekar S., Vodrážka P., Pejchal V., Mráz J., Šimek P.
  • Journal: Journal of Analytical Toxicology
  • Volume: 47
  • Issue: 1
  • Pages: 43–51
  • Year: 2023
Dr.Jaroslav Mráz, Pharmacokinetics,Excellence in Innovation

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