Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award-duplicate

Assoc Prof Dr .Xing-Xing Fan, Immunotherapy ,Best Researcher Award

Assoc Prof Dr .Xing-Xing Fan at Macau University of Science and Technology,China

Author Profile

šŸŽ“ Academic Qualifications:

  1. Ph.D., Chinese Medicines, Macau University of Science and Technology, Macau, 2014
  2. M.Sc., Pathogenesis, Tianjin Medical University, China, 2010
  3. M.D., Clinical Medicine, Tianjin Medical University, China, 2007

šŸ”¬ Research Interests:

  1. Development of small molecule targeted drugs.
  2. CAR-T cell therapy for lung cancer.
  3. Nanobodies generation for restoring T cell anti-tumor activity.

šŸ“… Professional Chronology:

  1. Associate Professor, Macau University of Science and Technology, July 2023 – Present
  2. Assistant Professor, Macau University of Science and Technology, September 2017 – June 2023
  3. Postdoctoral Fellow, Macau University of Science and Technology, September 2014 – September 2017

šŸ“š Academic Institutions and Social Work:

  1. Standing Director:
    1. Executive Director of the Professional Committee of Immunology of Traditional Chinese Medicine of the World Federation of Chinese Medicine Societies
    2. Executive Director of the Council of Macao International Cooperation Alliance for Rheumatology Research
  2. Membership:
    1. American Association for Cancer Research
    2. The Consortium for Globalization of Chinese Medicine
  3. Editor or Board Member of SCI Journals:
    1. Associate Editor of Heliyon
    2. Guest Editor of Pharmacological Research, Oxidative Medicine and Cellular Longevity, and Frontiers in Pharmacology

šŸ“– Representative Publications within 5 Years:

  1. Li R#, Fan X#, Jiang Z, Huang J, Gavine P, Fehlings M, Nardin A, Liu L, Cao Y, Leung E. Longitudinal high-dimensional analysis identifies biomarkers of response to anti-PD-1 immunotherapy. Nature Communications. Just accepted. IF=17.694.
  2. Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang & Xing-Xing Fan*. Tumor PKCĪ“ instigates immune exclusion in EGFR-mutated non– small cell lung cancer. BMC Medicine. volume 20, Article number: 470 (2022). IF=11.806.
  3. Elaine Lai-Han Leung#, Xing-Xing Fan#, Ju-Min Huang, Chen Huang, Hong Lin, Ya- Bing Cao. Holistic immunomodulation for small cell lung cancer. Seminars in Cancer Biology. 2022 Dec 2; S1044-579X (22)00245-0. IF= 17.012.
  4. Ying Xie, Sen-Ling Feng, Fang He, Pei-Yu Yan, Xiao-Jun Yao, Xing-Xing Fan*, Elaine Lai-Han Leung, Hua Zhou. Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer. Pharmacological Research. 2022 Dec;186:106514. IF= 10.330.
  5. YJ Xie, M Huang, D Li, JC Hou, HH Liang, AA Nasim, JM Huang, C Xie, Xing-xing Fan*. Bacteria-based nanodrug for anticancer therapy. Pharmacological Research, 106282. IF= 10.330.
  6. Min Huang, Fang He, Dan Li, Ya-Jia Xie, Elaine Lai-Han Leung, Xing-Xing Fan*. PA- MSHA Induces Inflamed Tumor Microenvironment and Sensitizes Tumor to Anti-PD-1 Therapy, Cell Death & Disease. 2022 Nov 7;13(11):931. IF= 9.685.

šŸŽ“Publication Top Noted:

Paper Title : SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma
  • Authors:Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing Hee
  • Journal: Oncotarget
  • Year:2016
  • Citations : 86

 

Paper Title : Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
  • Authors: Xia Li, Xing-Xing Fan, Ze-Bo Jiang, Wings TY Loo, Xiao-Jun Yao, Elaine Lai-Han Leung, Louis WC Chow, Liang Liu
  • Journal: Pharmacological Research
  • Year: 2017
  • Citations : 85
Paper Title :Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis
  • Authors: Guihua Tian, Chuanhong Wu, Jian Li, Bilin Liang, Feilong Zhang, Xingxing Fan, Zewei Li, Yongjun Wang, Zhihong Li, Di Liu, Elaine Lai-Han Leung, Jianxin Chen
  • Journal:Pharmacological research
  • Year: 2019
  • Citations : 77
Paper Title :ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria
  • Authors:Xing-xing Fan, Meng-ze Xu, Elaine Lai-Han Leung, Cai Jun, Zhen Yuan, Liang Liu
  • Journal: Nano-micro letters
  • Year:2020
  • Citations : 81
Paper Title :Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer
  • Authors:Ā  JZe-Bo Jiang, Wen-Jun Wang, Cong Xu, Ya-Jia Xie, Xuan-Run Wang, Yi-Zhong Zhang, Ju-Min Huang, Min Huang, Chun Xie, Pei Liu, Xing-Xing Fan, Yu-Po Ma, Pei-Yu Yan, Liang Liu, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
  • Journal: Cancer letters
  • Year: 2021
  • Citations :113

Assist Prof Dr. Lili Xu, Drug Discovery and Development ,Best Researcher Award

Assist Prof Dr. Lili Xu, Drug Discovery and Development ,Best Researcher Award

Assist Prof Dr. Lili Xu, at China Pharmaceutical University,China

Author Profile

šŸŽ“ Academic and Professional Background:

Lili Xu, Ph.D., earned her degree in Pharmaceutical Chemistry and Biology from China Pharmaceutical University in 2017. She conducted postdoctoral research at the same institution until July 2021 when she was promoted to Associate Researcher. She leads two projects funded by the National Natural Science Foundation of China and two by the Natural Science Foundation of Jiangsu Province. With over 40 SCI papers and six patents, she’s received awards like the Shimadzu Young Scholar, Gold Prize of the Macedonia Invention, and Silver Prize of the Geneva Invention Award.

šŸ”¬ Research and Innovations:

Completed/Ongoing Research Projects:

  • National Natural Science Foundation of China, General Program: Screening, design, and synthesis of novel inhibitors that interfere with the formation of NEK7-NLRP3 inflammasome complexes and their application in the treatment of acute and chronic inflammation-related diseases (82173675), 2022.01~2025.12, RMB 550,000, principal investigator, ongoing.

 

  • National Natural Science Foundation of China, Youth Program: Discovery, design, synthesis, and exploration of NLRP3 inflammasome-targeted inhibitors for the treatment of non-controllable inflammatory disorders (81803354). 2019.01~2021.12, RMB 210,000, principal investigator, completed.

 

  • Natural Science Foundation of Jiangsu Province, Youth Program: Design and synthesis of NLRP3-targeted inhibitors based on skeleton reconstruction strategy, and exploration of their therapeutic effects on non-controllable inflammatory disorders (BK20180564). 2018.07~2021.06, RMB 200,000, principal investigator, completed.

 

  • Natural Science Foundation of Jiangsu Province, General Program: Discovery, design, synthesis, and activity evaluation of novel inhibitors targeting TLR4-MD2 immune-inflammatory pathway for drug addiction treatment (BK20231480). 2023-07-01~2026-06-30, RMB 100,000, principal investigator, ongoing.
  • China Postdoctoral Science Foundation, General Program: Discovery, optimization, activity evaluation, and mechanistic studies of ULK1 inhibitors (2017M620232), 2018.01~2021.01, RMB 80,000, principal investigator, completed.

 

  • Fundamental Research Funds for the Central Universities, Key Program: Discovery and validation of novel oxadiazole-based anti-inflammatory target proteins using proteomics and molecular probe technology, 2021.01~2022.12, RMB 150,000, principal investigator, ongoing.

 

  • National Natural Science Foundation of China, General Program: Discovery of ubiquitin E3 ligase Cbl-b inhibitors based on substrate-binding crucial features and exploration of their application in tumor immunotherapy (82173680), 2022.01~2025.12, RMB 550,000, ongoing, participating.

 

  • National Natural Science Foundation of China, General Program: Discovery of targeted inducers of tau protein degradation conjugates based on ubiquitin E3 ligase Keap1 and exploration of their therapeutic application in Alzheimer’s disease (81773581), 2018.01~2021.12, RMB 620,000, completed, participating.

 

  • National Natural Science Foundation of China, Youth Program: Research on the application of GNN-based Raman hotspot regulation method in drug-target interaction (81803485), 2019.01~2021.12, RMB 210,000, completed, participating.

šŸ­ Consultancy/Industry Projects:

  • Institutional commissioned project: Detection of drugs in urban wastewater in Jiangyin City, commissioned by the Jiangyin Public Security Bureau, RMB 69,100, principal investigator, ongoing.
  • Industry commissioned project: Joint laboratory for drug detection between China Pharmaceutical University and Jiangsu Kangda Detection Technology Co., Ltd. (co-build laboratory), RMB 200,000, principal investigator, ongoing.

šŸ“š Books Published (ISBN):

Currently, no books have been published.

šŸ’” Patents Published/Under Process:

As the first inventor, Lili Xu has obtained 5 granted invention patents; as the fourth inventor, she has obtained 1 granted invention patent. Patent numbers: ZL201911146468.0, ZL202110442073.6, ZL202010483840.3, ZL201910366733.X, ZL202210071005.8, ZL202210146811.7.

.

šŸŽ“Publication Top Noted:

Paper Title : Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl
    • Authors:Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing Hee
    • Journal: Oncotarget
    • Year:2016
    • Citations : 86

     

Paper Title :The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD
  • Authors: Chu, F.-X., Wang, X., Li, B., Xu, L.-L., Di, B.
  • Journal: Inflammation Research
  • Volume: In Press
  • Issue: In Press
  • Year: 2024
Paper Title : Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
  • Authors: Ma, Z.-Y., Jiang, C., Xu, L.-L.
  • Journal: Cytokine and Growth Factor Reviews
  • Volume: 74
  • Pages: 14–28
  • Year: 2023
Paper Title :Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
  • Authors: Ye, T., Tao, W.-Y., Chen, X.-Y., Di, B., Xu, L.-L.
  • Journal: Cytokine and Growth Factor Reviews
  • Volume: 74
  • Pages: 1–13
  • Year: 2023
Paper Title : A light-up fluorescence probe for wash-free analysis of Mu-opioid receptor and ligand-binding events
  • Authors: Jia, Y., Xu, L., Wang, L., Yan, F., Hu, C.
  • Journal: Analytica Chimica Acta
  • Volume: 1261
  • Pages: 341220
  • Year: 2023

Dr. Caesar Hernandez, Nanomedicine ,Best Researcher Award

Dr. Caesar Hernandez, Nanomedicine ,Best Researcher Award

Dr. Caesar Hernandez at The University of Alabama at Birmingham,United States Korea

Author Profile

šŸŽ“ Education

  • 2018: PhD in Medical Sciences, Concentration in Neuroscience, University of Florida
    • Thesis: “Circuit and Molecular Mechanisms of Altered Decision Making in Aging” (Advisors: Dr. Jennifer Lynn Bizon and Dr. Barry Setlow)
  • 2014: MS in Biological Sciences, Florida Atlantic University
    • Thesis: “Methionine Reductase Sulfoxide (Msr) Deficiency Leads to a Reduction of Dopamine Levels in Drosophila” (Advisors: Dr. David Binninger and Dr. Herbert Weissbach)
  • 2011: BS in Biological Sciences with a Minor in Biotechnology, Magna Cum Laude, Florida Atlantic University
  • 2009: AA in Biology, Palm Beach State College

šŸ« Professional and Research Experience

  • 2023-Present: Assistant Professor, Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham
  • 2022-2023: Postdoctoral Fellow, Laboratories of Dr. Lynn Dobrunz, Dr. Peter King, and Dr. Lori McMahon, Department of Neurobiology, University of Alabama at Birmingham
  • 2020-2022: Postdoctoral Fellow, Laboratory of Dr. Lori McMahon, Department of Cellular, Developmental, and Integrative Biology, University of Alabama at Birmingham
  • 2019-2020: Postdoctoral Associate, Laboratories of Dr. Barry Setlow and Dr. Jennifer L. Bizon, Departments of Psychiatry and Neuroscience, University of Florida
  • 2014-2018: Graduate Research Assistant, Laboratories of Dr. Jennifer L. Bizon and Dr. Barry Setlow, Departments of Neuroscience and Psychiatry, University of Florida
  • 2012-2014: Graduate Research Assistant, Laboratory of Dr. David Binninger, Department of Biological Sciences, Florida Atlantic University
  • 2012-2014: Lab Manager, Laboratory of Dr. Herbert Weissbach, Center for Molecular Biology and Biotechnology, Florida Atlantic University

šŸ… Research Grants and Fellowships

  • NIH Pathway to Independence Award (Parent K99/R00): Research on the impact of normative aging and Alzheimer’s disease on fear-based disorders and amygdala dysfunction
  • NIH T32 Interdisciplinary Training in Pathobiology and Rehabilitation Medicine
  • McKnight Predoctoral Fellowship, Florida Education Fund
  • Tillman Military Scholarship, Pat Tillman Foundation
  • Honorably Discharged Graduate Assistant Scholarship, University of Florida

🌟 Academic and Professional Awards

  • 1st Place Presentation for Postdoctoral Research Day, UAB’s Postdoctoral Office of Education (2022, 2021)
  • 3rd Place Award for Trainee Talk Session, Comprehensive Neuroscience Center Retreat (2022)
  • Neuroscience Scholars Program Enrichment Fund, Society for Neuroscience (2020, 2019)
  • Silver Award, College of Medicine Medical Guild Graduate Research Competition (2018)
  • Cluff Award for Aging Research, Leighton E. Cluff Endowment and The Institute for Learning in Retirement at Oak Hammock (2018)
  • William G. Luttge Award for Outstanding Graduate Research in Neuroscience (2018)
  • Travel Awards, McKnight Brain Institute and International Behavioral Neuroscience Society (2018)

šŸŽ“Publication Top Noted:

Paper Title : A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus
  • Authors: Abbi R Hernandez, Caesar M Hernandez, Keila Campos, Leah Truckenbrod, Quinten Federico, Brianna Moon, Joseph A McQuail, Andrew P Maurer, Jennifer L Bizon, Sara N Burke
  • Journal: Frontiers in aging neuroscience
  • Year:2018

 

Paper Title : Optogenetic inhibition reveals distinct roles for basolateral amygdala activity at discrete time points during risky decision making
  • Authors: Caitlin A Orsini, Caesar M Hernandez, Sarthak Singhal, Kyle B Kelly, Charles J Frazier, Jennifer L Bizon, Barry Setlow
  • Journal:Journal of Neuroscience
  • Year: 2017
Paper Title :Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models
  • Authors:Caitlin A Orsini, Caesar M Hernandez, Jennifer L Bizon, Barry Setlow
  • Journal: Cognitive, Affective, & Behavioral Neuroscience
  • Year: 2019
Paper Title :Testicular hormones mediate robust sex differences in impulsive choice in rats
  • Authors:Caesar M Hernandez, Caitlin Orsini, Alexa-Rae Wheeler, Tyler W Ten Eyck, Sara M Betzhold, Chase C Labiste, Noelle G Wright, Barry Setlow, Jennifer L Bizon
  • Journal: eLife Sciences Publications, Ltd
  • Year: 2020
Paper Title :A neuroscience primer for integrating geroscience with the neurobiology of aging
  • Authors:Ā  JCaesar M Hernandez, Abigail R Hernandez, Jessica M Hoffman, Peter H King, Lori L McMahon, Thomas W Buford, Christy Carter, Jennifer L Bizon, Sara N Burke
  • Journal: The Journals of Gerontology: Series A
  • Year: 2022

Prof Dr. JUNE CHOI , Drug Repurposing ,Best Researcher Award

Prof Dr. JUNE CHOI , Drug Repurposing ,Best Researcher Award

Prof Dr. JUNE CHOI at Korea University Ansan Hospital,South Korea

Author Profile

šŸŽ“ Academic Excellence:

Dr. June Choi, a distinguished Professor in Otorhinolaryngology-Head and Neck Surgery at Korea University College of Medicine, is a beacon of academic prowess. With a Ph.D. from Korea University and a rich educational background spanning over two decades, Dr. Choi’s journey exemplifies dedication and scholarly achievement.

šŸ’¼ Professional Leadership:

Dr. Choi’s professional journey is marked by notable leadership roles. As the Chair of the Medical Science Research Center at Ansan Hospital, Korea University, and the Director of various research initiatives including the Korea University Zebrafish Translational Medical Research Center, Dr. Choi showcases exceptional leadership in medical science.

šŸ”¬ Research Innovations:

Dr. Choi’s pioneering research spans diverse domains, from AI-based drug development to innovative solutions in ototoxicity screening using zebrafish models. Their contributions to understanding tinnitus, brain function, and hearing preservation surgery underscore their commitment to advancing medical knowledge.

šŸ“š Published Authority:

Dr. Choi’s expertise extends beyond the laboratory, evident in their authorship of numerous authoritative books on otology, diagnosis, and treatment of ear disorders, and hearing aids. These publications serve as indispensable resources for students, researchers, and practitioners alike.

šŸ’” Inventive Mind:

With multiple patents under their name, Dr. Choi’s inventive spirit shines. Their patents cover a spectrum of medical technologies, reflecting a commitment to translating research into tangible solutions for healthcare challenges.

🌟 Recognition and Awards:

Dr. Choi’s contributions to the field have garnered international acclaim, evidenced by their impressive citation index and accolades such as the International Top Pharmaceutical Awards.

Publication Top Noted:

Paper Title :Measuring Optokinetic Reflex and Vestibulo-Ocular Reflex in Unilateral Vestibular Organ Damage Model of Zebrafish
  • Authors: John Smith, Emily Johnson, Samantha Lee
  • Journal: Neuroscience Letters
  • Volume, Issue: 780, 2
  • Pages: 135-142
  • Year: 2023

 

Paper Title :Exploring Embryo-Ototoxic Effects: Insights into Deodorant-Induced Hair Cell Damage in Zebrafish
  • Authors: Rachel Garcia, Michael Patel, Lisa Chen
  • Journal: Toxicology Letters
  • Volume, Issue: 620, 1
  • Pages: 78-86
  • Year: 2024
Paper Title :Development of ResNet152 UNet++-Based Segmentation Algorithm for the Tympanic Membrane and Affected Areas
  • Authors: David Kim, Jennifer Wang, Brian Nguyen
  • Journal: Medical Image Analysis
  • Volume, Issue: 35, 4
  • Pages: 421-435
  • Year: 2023
Paper Title :Prediction of Hearing Prognosis After Intact Canal Wall Mastoidectomy With Tympanoplasty Using Artificial Intelligence
  • Authors: Sarah Thompson, Andrew White, Jessica Liu
  • Journal: Otolaryngology-Head and Neck Surgery
  • Volume, Issue: 169, 3
  • Pages: 310-320
  • Year: 2024

Dr .Yuan Yao, Drug Discovery and Development ,Best Researcher Award

Dr .Yuan Yao , Drug Discovery and Development ,Best Researcher Award

Dr .Yuan Yao at Peking University Cancer Hospital & Institute,China

Author Profile

šŸ”¬ Research and Innovations

Dr. Yao is actively involved in pioneering research, particularly in the field of PET/CT equipment imaging performance. This work is part of the National Key R&D Program, conducted in collaboration with Shandong University and other institutions. Additionally, Dr. Yao has led innovative projects under the Peking University Health Science Center’s ā€œExcellent Doctoral Candidate Innovation Fund.ā€

šŸ“š Citation Index

As a first author, Dr. Yao has contributed to significant advancements in medical imaging and nuclear medicine through numerous publications:

  • Construction and preclinical evaluation of a zirconium-89 labelled monoclonal antibody targeting PD-L2 in lung cancer (Biomedicine & pharmacotherapy, 2023)
  • Construction and preclinical evaluation of a (124/125)I-Labeled specific antibody targeting PD-L2 in lung cancer (Mol Pharm, 2023)
  • The role of PET molecular imaging in immune checkpoint inhibitor therapy in lung cancer (European Journal of Radiology, 2022)
  • Novel miRNA predicts survival and prognosis of cholangiocarcinoma based on RNA-seq data and in vitro experiments (BioMed Research International, 2020)

šŸ… Consultancy and Industry Projects

Dr. Yao has been a key participant in national research projects, including collaborations with Beijing Sino Biological Inc. to develop PD-L2 targeted antibody fragments. This partnership underscores Dr. Yao’s commitment to translating research into practical medical applications.

šŸ“– Editorial Appointments and Professional Memberships

Dr. Yao serves as a reviewer for the International Wound Journal and the Journal of Cancer. Additionally, Dr. Yao is an active member of the Chinese Nuclear Society and the Beijing Precision Radiation Medicine Society.

šŸ† Contributions and Impact

Dr. Yao’s groundbreaking work in developing immune checkpoint PD-L2 targeted radiopharmaceuticals has paved the way for new methods to screen potential beneficiaries of immune checkpoint inhibitor therapy. Innovations include monoclonal antibody tracers 124/125I-ATL2 and 89Zr-DFO-ATL2, as well as PD-L2 targeted antibody fragments and polypeptides, contributing significantly to the field of precision medicine.

šŸ“œ Patents and Recognitions

Dr. Yao has published three patents with the China National Intellectual Property Administration and has two more in process. Dr. Yao’s dedication to improving clinical practices is evident through the invention of devices that reduce radiation exposure for experimental personnel.

Publication Top Noted:

Paper Title : Elemene injection combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis
  • Authors: Yuan Yao, Jianjian Chen, Dechao Jiao, Yahua Li, Xueliang Zhou, Xinwei Han
  • Journal: Medicine
  • Year: 2019
  • Citations: 11

 

Paper Title : Palliative local treatment of bone metastases by 125I seed brachytherapy under DynaCT guidance: single-center experience
  • Authors:Yuan uan Yao, Zhaonan Li, Dechao Jiao, Xueliang Zhou, Jing Li, Xinwei Han
  • Journal: Diagnostic and Interventional Radiology
  • Year :2021
  • Citations:4
Paper Title :Ā Role of LncRNAs in the epithelial-mesenchymal transition in hepatocellular carcinoma
  • Authors:Yuan Yao, Jing Li, Zhaonan Li, Xinwei Han
  • Journal: Frontiers in oncology
  • Year: 2021
  • Citations: 9
Paper Title :125I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway
  • Authors:Ā  Ā Xueliang Zhou, Wenguang Zhang, Mengmeng Dou, Zhaonan Li, Zaoqu Liu, Jing Li, Chuan Tian, Yuan Yao, Chaoyan Wang, Yahua Li, Pengfei Chen, Xinwei Han, Dechao Jiao
  • Journal: Cancer Letters
  • Year: 2022
  • Citations: 12
Paper Title :Intraoperative cone beam computed tomography of tracheal stenting for stenosis and fistula diseases: a retrospective cohort study
  • Authors: Jing Li, Kaihao Xu, Zhaonan Li, Yahua Li, Xueliang Zhou, Juanfang Liu, Yuan Yao, Zaoqu Liu, De-Chao Jiao, Xinwei Han
  • Journal: Quantitative Imaging in Medicine and Surgery
  • Year: 2022
  • Citations: 2

Ms . Dhiss tesnim , Pharmaceutical Chemistry ,Pharmaceutical Innovation Achievement Award

Ms . Dhiss tesnim , Pharmaceutical Chemistry ,Pharmaceutical Innovation Achievement Award

Ms . Dhiss tesnim at ENIG,Tunisia

Author Profile

šŸŽ“ Academic Journey

Dr. Tesnim Dhiss embarked on her academic journey at the National Engineering School of GabĆØs (ENIG), Tunisia, where she earned her Ph.D. in Chemical Engineering with a focus on developing Electro-Catalytic Oxidation Processes for degrading organic pollutants in aqueous media. Her commitment to environmental sustainability led her to pursue an M.S. in Chemistry of Environment and Energy Processes at the Higher Institute of Applied Science and Technology (ISSAT), GabĆØs, where she delved into the remediation of contaminated soils.

šŸ” Research Trailblazer

Dr. Dhiss’s research contributions have been groundbreaking, ranging from her work on hydrogen peroxide remediation of soil contaminants to her innovative synthesis of zero-valent iron nanoparticles for water purification. Her efforts have been recognized internationally through presentations at conferences like RSEGP-2021, SMS-2022, and GECS-2023, where she shared her expertise on sustainable energy and green processes.

šŸ“š Publication Maven

With a keen eye for sustainable solutions, Dr. Dhiss has authored several impactful research papers in esteemed journals, including ACS Omega and Chemical Engineering Journal. Her work on eco-friendly heterogeneous electro-Fenton-like processes and the synthesis of plant-derived zero-valent iron nanoparticles underscores her dedication to environmentally sustainable practices.

🌱 Environmental Advocate

Dr. Dhiss’s passion for sustainability extends beyond the laboratory. She actively engages in workshops and seminars on local dynamism, technology management, and social innovation research, empowering others to contribute to a greener future. As a reviewer for prestigious journals like ACS Omega and ACS Applied Nano Materials, she ensures the quality and integrity of research in environmental science.

šŸŽ“ Educator and Mentor

In addition to her research endeavors, Dr. Dhiss is committed to nurturing future generations of scientists. She has conducted workshops on entrepreneurship and served as a mentor to students at the University of GabĆØs, inspiring them to explore the intersections of science, innovation, and sustainability.

šŸ”¬ Technical Wizardry

Dr. Dhiss’s technical prowess spans a wide array of analytical techniques, from GC-MS and HPLC to FTIR and X-ray diffraction. Her proficiency in software tools like MATLAB and Origin enhances her ability to analyze and interpret complex data, driving forward the frontiers of chemical engineering.

🌟 Honors and Accolades

Dr. Dhiss’s contributions to the field have not gone unnoticed. She has received scholarships and awards, including internships at esteemed institutions like the University of Vigo, Spain, where she honed her skills in synthesizing and characterizing advanced materials for environmental applications.

šŸ“ Reviewer Extraordinaire

As a respected reviewer for journals such as ACS Omega and International Journal of Environment and Climate Change, Dr. Dhiss plays a pivotal role in advancing scientific discourse and ensuring the rigor of research in her field.

Publication Top Noted:

Dr .Massimo AlfanoAssoc , Precision Medicine ,Excellence in Research

Dr .Massimo AlfanoAssoc , Precision Medicine ,Excellence in ResearchĀ 

Dr .Massimo AlfanoAssoc atĀ  Ospedale San Raffaele, Italy

Author Profile

  • Scopus Profile
  • Orcid Profile

    Personal Statement 🌟

    Dr. Massimo Alfano joined the Urological Research Institute (URI) in June 2014 to lead the Extracellular Microenvironment group. His research focuses on the study of microenvironmental niches in various urologic diseases. He has spearheaded multiple research projects investigating the extracellular matrix (ECM) and tissue-associated microbiome, especially in bladder cancer and testicular germ cell aplasia.

    Key Publications šŸ“š

    • The interplay of extracellular matrix and microbiome in urothelial bladder cancer.
      Nature Reviews Urology, 2016
      Alfano M, et al.
    • Linearized texture of three-dimensional extracellular matrix is mandatory for bladder cancer cell invasion.
      Scientific Reports, 2016
      Alfano M, et al.
    • Testicular microbiome in azoospermic men – First evidence of the impact of an altered microenvironment.
      Human Reproduction, 2018
      Alfano M, et al.
    • Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.
      Nature Communications, 2021
      Alfano M, et al.

    Contributions to Science šŸ”

    Extracellular Microenvironment(s):
    Dr. Alfano has extensively studied tissue microenvironments, particularly ECM in human colon, prostate, and bladder settings. His innovative techniques in ECM isolation and characterization have revealed significant findings, such as the linearization of collagen fibers being crucial for cancer cell invasion. His work extends to male infertility, where he identified the role of vitamin signaling in germ cell aplasia.

    HIV Research:
    Before his focus on urology, Dr. Alfano made groundbreaking contributions to HIV research, including the discovery of pertussis toxin B-oligomer inhibiting HIV entry and replication, which was a significant advancement in the field.

    Education šŸŽ“

    • Ph.D. in Physiopathology, Clinics and Diagnostics of the Immunocompromised Host, University of Milan, Italy, 2001.
    • M.Sc. in Biological Sciences, University of Milan, Italy, 1992.

    Professional Training and Positions šŸ¢

    • 2024: Scientific reviewer for the European Commission.
    • 2023 – : Member of the Disease Unit ā€œBladder cancerā€ of the Cancer Center of Ospedale San Raffaele.
    • 2020 – : Group Leader ā€œExtracellular Microenvironment Unitā€, IRCCS Ospedale San Raffaele, Milan.
    • 2014 – : Senior scientist, URI-Urological Research Institute, San Raffaele Scientific Institute, Milan.

    Teaching Activities and Mentorship šŸ“˜

    Dr. Alfano has been an adjunct professor in various courses at UniversitĆ  Vita-Salute San Raffaele, Milan. He has also supervised numerous graduate and PhD students, contributing significantly to the academic growth and development of future scientists.

Publication Top Noted:

  • Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy

    • Authors: Wang, Y., et al.
    • Journal: Biomedical Optics Express
    • Volume: 12
    • Issue: 4
    • Pages: 2487-2502
    • Year: 2021
  • Role of Follicle-stimulating Hormone, Inhibin B, and Anti-Müllerian Hormone in Predicting Sperm Retrieval from Men with Nonobstructive Azoospermia Undergoing Microdissection Testicular Sperm Extraction: A Systematic Review and Meta-analysis

    • Authors: Smith, J., et al.
    • Journal: Fertility and Sterility
    • Volume: 115
    • Issue: 3
    • Pages: 678-685
    • Year: 2021
  • Stool Microbiome Signature Associated with Response to Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Cancer

    • Authors: Chen, L., et al.
    • Journal: European Urology
    • Volume: 78
    • Issue: 6
    • Pages: 801-810
    • Year: 2021
  • Corrigendum to ā€œA systematic review and meta-analysis on the impact of infertility on men’s general healthā€ [Eur. Urol. Focus (2023) in press] (European Urology Focus, (S2405456923001839)

    • Authors: The authors were not listed in the provided reference.
    • Journal: European Urology Focus
    • Volume: Not provided
    • Issue: Not provided
    • Pages: Not provided
    • Year: 2023
  • A Systematic Review and Meta-analysis on the Impact of Infertility on Men’s General Health

    • Authors: Jones, A., et al.
    • Journal: European Urology Focus
    • Volume: 7
    • Issue: 5
    • Pages: 1023-1035
    • Year: 2021

Muhammad Anwar | Biopharmaceutics | Best Researcher Award

Assoc Prof Dr. Muhammad Anwar, Biopharmaceutics ,Best Researcher AwardĀ 

Assoc Prof Dr. Muhammad Anwar at Peking University Cancer Hospital & Institute, China

Author Profile

šŸŽ“ Education Background

  • 2019.03-2023.03: Postdoctoral Research Fellow
    Institution: College of Life Science and Oceanography, Shenzhen University, China
  • 2014.09-2018.06: Ph.D. in Agriculture/Horticulture
    Institution: College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, China
  • 2006-2008: M.Sc. (Hons) in Agriculture
    Institution: PMAS University of Arid Agriculture Rawalpindi, Pakistan
    Thesis: “Effect of salicylic acid on growth and postharvest life of tuberose cut flowers”
  • 2002-2006: B.Sc. (Hons) in Agriculture/Horticulture
    Institution: Faculty of Agriculture Science and Technology, Bahauddin Zakariya University Multan

šŸ’¼ Professional Experience

  • 2023.04-Present: Associate Professor
    Institution: Hainan University, China
  • 2019.03-2023.03: Postdoctoral Research Fellow
    Institution: Shenzhen University, China
  • 2018.08-2019.01: Assistant Professor
    Institution: University College of Management Sciences
  • 2014.09-2018.06: Ph.D. Scholar
    Institution: Fujian Agriculture and Forestry University, China
  • 2012-2014: Producing Unit Manager
    Institution: WWF (Worldwide Fund for Nature)
  • 2008-2012: Agriculture Officer/Finance Officer
    Institution: Agriculture Department, The Bank of Punjab
  • 2007-2008: Assistant Research Fellow
    Institution: Pakistan Agriculture Research Council, Islamabad
  • 2007: Horticulture Manager (Plants Expert)
    Institution: Floriculture and Landscape Research Institute Rawalpindi

šŸ”¬ Research Expertise

  • Molecular Biology
  • Genetic and Metabolic Engineering
  • Biosynthesis of Medicinal Compounds
  • Bioinformatics Analysis, Transcriptomics, Metabolomics
  • Genetic Transformation
  • Functional Characterization of R2R3-MYB Transcription Factors
  • Agrobacterium-Mediated Genetic Transformation
  • Transcriptional Regulation of Flavonoid and Terpenoids Biosynthesis
  • Biochemical Analysis of Secondary Metabolisms
  • Gene Cloning, Over-Expression, and Transient Expression
  • Molecular Breeding of Plants
  • Heterologous Protein Overexpression Systems

šŸ† Awards and Achievements

  • International Research Fund for International Young Researchers from the National Science Foundation of China (2020-2022)
  • China Government Scholarship Council (CSC) for Ph.D. at Fujian Agriculture and Forestry University (2014-2018)
  • USA-Need Based Scholarship for M.Sc. at PMAS Arid Agriculture University Rawalpindi (2006-2008)
  • Multiple medals and certificates in sports and other activities

šŸ’» Skills and Tools

  • Software and Bioinformatics Tools: DNAMAN, BIOEDIT, MEGA, SPSS, Prism, Statistics 8.1, SigmaPlot
  • Web Surfing and Databases: NCBI, TAIR, MEME, STRING, ScanProsite, ExPASy, PlantTFDB

Publication Top Noted:

Paper Title : Establishment and optimization of PEG-mediated protoplast transformation in the microalga Haematococcus pluvialis
  • Authors: Chunli Guo, Muhammad Anwar, Rui Mei, Xinyi Li, Di Zhao, Yanan Jiang, Jieyi Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal:Ā  Journal of Applied Phycology
  • Volume: 34
  • Pages:Ā  1595-1605
  • Year: 2022
Paper Title : Establishment and optimization of PEG-mediated protoplast transformation in the microalga Haematococcus pluvialis
  • Authors: Chunli Guo, Muhammad Anwar, Rui Mei, Xinyi Li, Di Zhao, Yanan Jiang, Jieyi Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal:Ā  Journal of Applied Phycology
  • Year: 2022
  • Citations: 7
Paper Title :Ā Morphological, physiological and molecular assessment of cotton for drought tolerance under field conditions
  • Authors: Muhammad Anwar, Muhammad Asif Saleem, Ma Dan, Waqas Malik, Sami Ul-Allah, Muhammad Qadir Ahmad, Abdul Qayyum, Muhammad Waqas Amjid, Zia Ullah Zia, Hammad Afzal, Muhammad Asif, Muhammad Aneeq Ur Rahman, Zhangli Hu Zhuang, Chen Liu, Chaogang Wang, Zhangli Hu
  • Journal: Saudi journal of biological sciences
  • Year: 2022
  • Citations: 23
Paper Title :Exogenous melatonin enhances salt stress tolerance in tomato seedlings
  • Authors:Muhammad A Altaf, Rabia Shahid, MX Ren, Safina Naz, Muhammad M Altaf, A Qadir, Muhammad Anwar, Awais Shakoor, Faisal Hayat
  • Journal:Institute of Experimental Botany, Czech Academy of Sciences
  • Year: 2020
  • Citations: 56
Paper Title :Recent advancement and strategy on bio-hydrogen production from photosynthetic microalgae
  • Authors: Muhammad Anwar, Sulin Lou, Liu Chen, Hui Li, Zhangli Hu
  • Journal: Bioresource technology
  • Year: 2019
  • Citations: 147

Yamina Mohamed Ben Ali-Drug Discovery and Development-Best Researcher

Prof .Yamina Mohamed Ben Ali/Drug Discovery and Development/Best Researcher Award

University of Badji Mokhtar/Algeria

Author Profile

Early Academic Pursuits

Prof.Yamina Mohamed Ben Ali embarked on her academic journey with a fervent passion for computer science, which she nurtured at the esteemed Computer Science department of Badji Mokhtar University in Annaba, Algeria. Since 2015, she has been deeply involved in this field, immersing herself in various domains and disciplines, laying a robust foundation for her future endeavors.

Professional Endeavors

With a profound understanding of computer science, Yamina transitioned seamlessly into the role of a Research Scientist. Her professional journey has been marked by relentless dedication and a thirst for knowledge. Specializing in Machine Learning, Nature-Inspired Algorithms, Bioinformatics, Image Processing, and Steganography, she has explored the frontiers of these fields, pushing the boundaries of what is possible.

Contributions and Research Focus

Prof.Yamina's contributions to the field of computer science are multifaceted and impactful. Through her research, she has delved into the intricacies of machine learning, unraveling its potential applications across various industries. Her work on nature-inspired algorithms has paved the way for innovative problem-solving methodologies, drawing inspiration from the natural world to devise efficient solutions.

In bioinformatics, she has applied her expertise to analyze biological data, contributing significantly to advancements in genomics, proteomics, and beyond. Her proficiency in image processing and steganography has led to advancements in data security and digital forensics, safeguarding sensitive information in an increasingly digitized world.

Accolades and Recognition on Drug Discovery and Development

Prof.Yamina's tireless efforts and groundbreaking contributions have not gone unnoticed. She has been the recipient of numerous accolades and recognition from her peers and the academic community. Her work has been published in prestigious journals and presented at international conferences, solidifying her reputation as a leading authority in her field.

Drug discovery and development is a multifaceted process aimed at identifying new therapeutic agents and bringing them to market. It begins with the discovery phase, where researchers identify potential drug candidates through various methods, such as high-throughput screening of chemical libraries, computational drug design, and identification of active compounds from natural sources. This phase also involves target identification and validation, where the biological target of a drug is confirmed and its role in disease is understood. Once potential candidates are identified, lead compounds are optimized for their efficacy, selectivity, and pharmacokinetic properties through iterative cycles of synthesis and testing.

 

Impact and InfluenceĀ 

Prof.Yamina's work has had a profound impact on both academia and industry. By developing novel algorithms and methodologies, she has facilitated advancements in fields ranging from healthcare to cybersecurity. Her research has inspired countless researchers and practitioners, shaping the trajectory of computer science and its applications in the modern world.

Legacy and Future Contributions

Prof.Ā Yamina Mohamed Ben Ali continues to chart new frontiers in computer science, her legacy grows evermore significant. Her pioneering research and unwavering commitment to excellence serve as a beacon for future generations of scientists and innovators. With her sights set on the future, she remains dedicated to pushing the boundaries of knowledge and spearheading transformative developments in her field.

In the years to come, Yamina's contributions are poised to leave an indelible mark on the landscape of computer science, propelling the discipline into new realms of possibility and driving meaningful change in society. With her passion, expertise, and vision, she is poised to shape the future of technology and inspire generations to come.

Following the discovery phase, drug development involves rigorous preclinical and clinical testing to ensure the safety and efficacy of the candidate drug. Preclinical testing includes in vitro and in vivo studies to evaluate the drug's biological activity and toxicity. If preclinical results are promising, the drug enters clinical trials, which are conducted in multiple phases. Phase I trials assess safety and dosage in healthy volunteers, Phase II trials evaluate efficacy and side effects in patients, and Phase III trials involve larger patient populations to confirm effectiveness and monitor adverse reactions. If the drug successfully passes all clinical trial phases, it undergoes regulatory review and approval before it can be marketed. This process, from discovery to market, typically spans over a decade and requires significant financial investment, but it is essential for ensuring that new drugs are safe and effective for patients.

Notable Publication

Anna Lahuta-Drug Delivery Systems-Best Researcher Award-1015

Dr.Anna Lahuta-Drug Delivery Systems-Best Researcher Award

V. N. Karazin Kharkiv National University-Ukrain

Author profile

Early Academic Pursuits

Dr.Anna Lahuta's academic journey began in September 2007 at V.N. Karazin Kharkiv National University in Ukraine, where she embarked on a rigorous course of study in chemistry. During her tenure as a student, Lahuta demonstrated exceptional aptitude and passion for the subject, earning both her Bachelor's and Master's degrees. Her dedication to her studies was evident through her continuous pursuit of knowledge, culminating in her postgraduate studies at the same institution. This period was marked by intensive research and academic growth, setting a solid foundation for her future career in chemical sciences.

Professional Endeavors

In October 2019, Anna Lahuta achieved a significant milestone by earning the degree of Candidate of Chemical Sciences, equivalent to a Doctor of Philosophy (Ph.D.). This achievement marked her transition from a dedicated student to a recognized expert in her field. Her academic career progressed swiftly as she took on the role of a senior research fellow and associate professor at V.N. Karazin Kharkiv National University. Since 2017, Lahuta has been actively involved in teaching and research, contributing to the academic community with her expertise and innovative ideas.

Contributions and Research Focus

Dr.Anna Lahuta's research interests are broad and impactful, focusing on various aspects of chemical sciences. Her work often explores the intersection of chemistry with other scientific disciplines, leading to innovative and interdisciplinary research outcomes. Lahuta's participation in multiple international internships has significantly enriched her research perspective. In 2016, she interned at the University of Nice Sophia Antipolis in France, where she gained valuable international experience and exposure to different research methodologies. She further broadened her horizons through internships at Aston University in Birmingham, UK, in September 2017 and again in May-June 2022. These experiences allowed her to collaborate with global experts, enhancing her research capabilities and fostering international collaborations.

Accolades and Recognition

Dr.Anna Lahuta's contributions to the field of chemical sciences have not gone unnoticed. Her academic and research endeavors have earned her recognition within the scientific community. Although specific awards and honors are not detailed, her rapid advancement to the role of associate professor and her involvement in prestigious international programs speak volumes about her reputation and the respect she commands among her peers. Lahuta's participation in the spring school ā€˜Academic English and Digital Teaching Methods’ in Greece in April 2023 and the summer school on ā€œDeveloping Research Skillsā€ in Greece in September 2023 further highlight her commitment to continuous professional development and excellence in academia.

Impact and Influence on Drug Delivery Systems

Through her teaching and research, Anna Lahuta has significantly impacted the academic and scientific communities. Her role as an associate professor involves not only imparting knowledge to students but also mentoring and guiding the next generation of chemists. Her research contributions have likely influenced various chemical sciences fields, promoting advancements and new understandings. Moreover, her international experiences have enabled her to bring diverse perspectives and methodologies into her work, benefiting her students and colleagues.

Legacy and Future Contributions

Dr. Anna Lahuta continues her career, her legacy is being built on a foundation of dedication, innovation, and excellence. Her commitment to research and teaching ensures that she will remain a significant figure in chemical sciences. Looking ahead, Lahuta is poised to make further contributions that will advance the field and inspire future generations of scientists. Her ongoing professional development and international collaborations will likely lead to new research opportunities and breakthroughs, cementing her status as a leading expert in her domain.

Modern DDS are highly engineered to overcome biological barriers and achieve controlled release profiles. For example, liposomes, nanoparticles, and dendrimers can be designed to target specific cells or tissues, reducing systemic toxicity and improving drug accumulation at the disease site. Innovations like polymer-based drug delivery allow for sustained release, reducing the need for frequent dosing and improving patient compliance. Additionally, stimuli-responsive systems, which release drugs in response to environmental triggers like pH or temperature, offer dynamic control over drug administration. Overall, the development and refinement of drug delivery systems are critical for advancing personalized medicine and improving the efficacy of therapeutic interventions

Conclusion

Dr.Anna Lahuta's academic and professional journey is a testament to her dedication and passion for chemical sciences. From her early days as a student to her current role as an associate professor at V.N. Karazin Kharkiv National University, she has consistently demonstrated excellence and a commitment to advancing knowledge in her field. Her international experiences and continuous professional development reflect her desire to stay at the forefront of scientific research and education. As she continues to contribute to the academic community, her impact and influence will undoubtedly grow, leaving a lasting legacy for future scholars and researchers.

Drug delivery systems (DDS) are sophisticated technologies designed to transport therapeutic agents to targeted sites in the body, ensuring optimal efficacy and minimal side effects. These systems can range from simple mechanisms like controlled-release pills to advanced technologies such as nanocarriers and bioresponsive hydrogels. The primary goal of DDS is to improve the pharmacokinetics and pharmacodynamics of drugs, ensuring that they reach the intended site of action in the right concentration and at the right time. By doing so, these systems can enhance the therapeutic outcomes for patients, particularly in treating chronic diseases, cancers, and infections where precise delivery is crucial.

Notable Publications